Interactor	Canonical Name	Naming Convention	Major Loc With Loc Score	Minor Loc	Loc Experimental System Type	Loc Source DB	Interaction Source DB	Taxonomy ID
A4D1B5	Gamma-secretase-activating protein	UniProtKB/Swiss-Prot/P	Cytosol(0.94)|Secretory-pathway(0.8)|Membrane(0.7)	GO:0005737|GO:0043231|GO:0005802|GO:0016021	Predicted: SVM decision tree|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Predicted: SVM decision tree	eSLDB|The Human Protein Atlas|GO|eSLDB		9606
P49768	Presenilin-1	UniProtKB/Swiss-Prot/P	Membrane(1)|Cytosol(1)|Mitochondrion(0.988)|Nucleus(1)|Secretory-pathway(1)|Extracellular(0.8)	GO:0009986|GO:0012505|GO:0043025|GO:0016235|GO:0048471|GO:0005938|GO:0005739|GO:0005739|GO:0005743|GO:0005634|GO:0005634|GO:0005634|GO:0031965|GO:0005640|GO:0005639|GO:0032991|GO:0005783|GO:0005783|GO:0005783|GO:0005791|GO:0005790|GO:0005789|GO:0005794|GO:0005794|GO:0005794|GO:0005794|GO:0000139|GO:0005765|GO:0030018|GO:0005813|GO:0005694|GO:0000776|GO:0030426|GO:0043198|GO:0030424|GO:0035253|GO:0005576|GO:0016020|GO:0016021|GO:0016021|GO:0045121|GO:0005886|GO:0005886|GO:0070765|GO:0005887|GO:0019866|GO:0031982|GO:0030054|GO:0030054|GO:0031594	Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from mutant phenotype|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Experimental: annotated protein expression (APE)|Unknown: inferred from electronic annotation|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: experimental|Experimental: inferred from direct assay|Experimental: annotated protein expression (APE)|Predicted: inferred from biological aspect of ancestor	GO|Organelle|GO|GO|GO|GO|GO|Organelle|GO|GO|Organelle|The Human Protein Atlas|GO|GO|Organelle|GO|eSLDB|GO|Organelle|GO|GO|GO|eSLDB|GO|PA-GOSUB|The Human Protein Atlas|GO|GO|GO|GO|Organelle|GO|GO|GO|GO|GO|MatrixDB|GO|eSLDB|GO|GO|GO|Organelle|GO|GO|Organelle|eSLDB|GO|The Human Protein Atlas|GO	BioGRID	9606
P05067	Amyloid-beta A4 protein	UniProtKB/Swiss-Prot/P	Secretory-pathway(1)|Membrane(1)|Cytosol(1)|Nucleus(0.96)|Extracellular(0.98)	GO:secretory_pathway|GO:0009986|GO:0005905|GO:0045177|GO:0005737|GO:0005737|GO:0005829|GO:0048471|GO:0043231|GO:0005634|GO:0005641|GO:0005783|GO:0005791|GO:0005790|GO:0005788|GO:0005794|GO:0005794|GO:0005794|GO:0005796|GO:0032588|GO:0005768|GO:0005768|GO:0031904|GO:0005764|GO:0031093|GO:0030134|GO:0051233|GO:0097449|GO:0043198|GO:0043197|GO:0030424|GO:0044304|GO:0035253|GO:0005576|GO:0005576|GO:0005576|GO:0005615|GO:0016020|GO:0016021|GO:0016021|GO:0045121|GO:0005886|GO:0005886|GO:0005886|GO:0005887|GO:0043235|GO:0031982|GO:0070062|GO:0005911|GO:0045202|GO:0031594|GO:0048786	Experimental: experimental|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Unknown: traceable author statement|Experimental: inferred from direct assay|Experimental: annotated protein expression (APE)|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation|Unknown: traceable author statement|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Experimental: annotated protein expression (APE)|Unknown: traceable author statement|Unknown: traceable author statement|Experimental: experimental|Experimental: inferred from direct assay|Unknown: traceable author statement|Experimental: experimental|Unknown: traceable author statement|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Predicted: inferred from sequence or structural similarity|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation|Experimental: experimental|Unknown: traceable author statement|Experimental: experimental|Unknown: HDA|Experimental: experimental|Predicted: SVM decision tree|Predicted: inferred from sequence or structural similarity|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Predicted: pTarget method|Experimental: experimental|Unknown: traceable author statement|Experimental: inferred from direct assay|Experimental: experimental|Unknown: HDA|Unknown: inferred from electronic annotation|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation	eSLDB|GO|GO|GO|eSLDB|GO|GO|GO|The Human Protein Atlas|eSLDB|GO|eSLDB|GO|GO|GO|eSLDB|GO|The Human Protein Atlas|GO|GO|eSLDB|GO|GO|eSLDB|GO|GO|GO|GO|GO|GO|GO|GO|GO|eSLDB|GO|MatrixDB|GO|MatrixDB|eSLDB|GO|GO|GO|LOCATE|Organelle|GO|GO|eSLDB|GO|GO|GO|GO|GO	BioGRID|DIP|IntAct	9606
Q92542	Nicastrin	UniProtKB/Swiss-Prot/P	Cytosol(0.902)|Nucleus(0.8)|Secretory-pathway(0.999)|Extracellular(0.8)|Membrane(0.999)	GO:0005829|GO:0005634|GO:0005783|GO:0005783|GO:0005783|GO:0005794|GO:0005794|GO:0005765|GO:0042470|GO:0005576|GO:0016020|GO:0016021|GO:0016021|GO:0005886|GO:0005886|GO:0070765|GO:0005887|GO:0070062|GO:0005925	Experimental: annotated protein expression (APE)|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Experimental: experimental|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Predicted: pTarget method|Unknown: HDA|Unknown: inferred from electronic annotation|Experimental: experimental|Unknown: HDA|Predicted: SVM decision tree|Unknown: non-traceable author statement|Unknown: traceable author statement|Experimental: experimental|Experimental: inferred from direct assay|Predicted: inferred from sequence or structural similarity|Unknown: HDA|Unknown: HDA	The Human Protein Atlas|Human Proteinpedia|GO|Human Proteinpedia|Organelle|GO|LOCATE|GO|GO|MatrixDB|GO|eSLDB|GO|GO|Organelle|GO|GO|GO|GO	BioGRID	9606
A0A0A0MRG2	Amyloid-beta A4 protein	UniProtKB/TrEmbl/P	Cytosol(0.8)|Secretory-pathway(0.8)|Membrane(0.7)	GO:0043231|GO:0005794|GO:0016021	Experimental: annotated protein expression (APE)|Experimental: annotated protein expression (APE)|Predicted: SVM decision tree	The Human Protein Atlas|The Human Protein Atlas|eSLDB	BioGRID	9606
Q9NZ42	Gamma-secretase subunit PEN-2	UniProtKB/Swiss-Prot/P	Secretory-pathway(1)|Extracellular(0.8)|Membrane(0.999)	GO:0005783|GO:0005783|GO:0005789|GO:0005794|GO:0005794|GO:0005794|GO:0032580|GO:0005576|GO:0016021|GO:0016021|GO:0005886|GO:0070765|GO:0005887	Experimental: experimental|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: experimental|Experimental: inferred from direct assay|Unknown: traceable author statement|Experimental: inferred from direct assay|Experimental: inferred from direct assay	eSLDB|GO|GO|eSLDB|GO|PA-GOSUB|GO|MatrixDB|eSLDB|GO|GO|GO|GO	BioGRID	9606
E9PG40	Amyloid-beta A4 protein	UniProtKB/TrEmbl/P	Cytosol(0.8)|Secretory-pathway(0.8)	GO:0043231|GO:0005794	Experimental: annotated protein expression (APE)|Experimental: annotated protein expression (APE)	The Human Protein Atlas|The Human Protein Atlas	BioGRID	9606
A0A024R6A3	Presenilin	UniProtKB/TrEmbl/P	Extracellular(0.8)	GO:0005576	Experimental: experimental	MatrixDB	BioGRID	9606
A0A0S2Z4D2	Presenilin	UniProtKB/TrEmbl/P	Extracellular(0.8)	GO:0005576	Experimental: experimental	MatrixDB	BioGRID	9606