Interactor	Canonical Name	Naming Convention	Major Loc With Loc Score	Minor Loc	Loc Experimental System Type	Loc Source DB	Interaction Source DB	Taxonomy ID
Q9NZ42	Gamma-secretase subunit PEN-2	UniProtKB/Swiss-Prot/P	Secretory-pathway(1)|Extracellular(0.8)|Membrane(0.999)	GO:0005783|GO:0005783|GO:0005789|GO:0005794|GO:0005794|GO:0005794|GO:0032580|GO:0005576|GO:0016021|GO:0016021|GO:0005886|GO:0070765|GO:0005887	Experimental: experimental|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: experimental|Experimental: inferred from direct assay|Unknown: traceable author statement|Experimental: inferred from direct assay|Experimental: inferred from direct assay	eSLDB|GO|GO|eSLDB|GO|PA-GOSUB|GO|MatrixDB|eSLDB|GO|GO|GO|GO		9606
P49768	Presenilin-1	UniProtKB/Swiss-Prot/P	Membrane(1)|Cytosol(1)|Mitochondrion(0.988)|Nucleus(1)|Secretory-pathway(1)|Extracellular(0.8)	GO:0009986|GO:0012505|GO:0043025|GO:0016235|GO:0048471|GO:0005938|GO:0005739|GO:0005739|GO:0005743|GO:0005634|GO:0005634|GO:0005634|GO:0031965|GO:0005640|GO:0005639|GO:0032991|GO:0005783|GO:0005783|GO:0005783|GO:0005791|GO:0005790|GO:0005789|GO:0005794|GO:0005794|GO:0005794|GO:0005794|GO:0000139|GO:0005765|GO:0030018|GO:0005813|GO:0005694|GO:0000776|GO:0030426|GO:0043198|GO:0030424|GO:0035253|GO:0005576|GO:0016020|GO:0016021|GO:0016021|GO:0045121|GO:0005886|GO:0005886|GO:0070765|GO:0005887|GO:0019866|GO:0031982|GO:0030054|GO:0030054|GO:0031594	Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from mutant phenotype|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Experimental: annotated protein expression (APE)|Unknown: inferred from electronic annotation|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: experimental|Experimental: inferred from direct assay|Experimental: annotated protein expression (APE)|Predicted: inferred from biological aspect of ancestor	GO|Organelle|GO|GO|GO|GO|GO|Organelle|GO|GO|Organelle|The Human Protein Atlas|GO|GO|Organelle|GO|eSLDB|GO|Organelle|GO|GO|GO|eSLDB|GO|PA-GOSUB|The Human Protein Atlas|GO|GO|GO|GO|Organelle|GO|GO|GO|GO|GO|MatrixDB|GO|eSLDB|GO|GO|GO|Organelle|GO|GO|Organelle|eSLDB|GO|The Human Protein Atlas|GO	HPRD|BioGRID	9606
P49810	Presenilin-2	UniProtKB/Swiss-Prot/P	Membrane(1)|Cytosol(1)|Mitochondrion(0.7)|Nucleus(1)|Secretory-pathway(1)|Extracellular(0.8)	GO:0009986|GO:0012505|GO:0043025|GO:0048471|GO:0005938|GO:0005743|GO:0005634|GO:0005634|GO:0005637|GO:0005639|GO:0032991|GO:0005783|GO:0005783|GO:0005783|GO:0005789|GO:0005794|GO:0005794|GO:0005794|GO:0000139|GO:0005765|GO:0030018|GO:0005813|GO:0005694|GO:0000776|GO:0030426|GO:0043198|GO:0030424|GO:0035253|GO:0005576|GO:0016020|GO:0016021|GO:0045121|GO:0005886|GO:0005886|GO:0005887|GO:0019866|GO:0031594	Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Unknown: inferred from electronic annotation|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: inferred from direct assay|Experimental: experimental|Experimental: inferred from direct assay|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Unknown: HDA|Experimental: experimental|Predicted: inferred from biological aspect of ancestor|Unknown: traceable author statement|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Predicted: inferred from biological aspect of ancestor	GO|Organelle|GO|GO|GO|GO|Organelle|The Human Protein Atlas|GO|Organelle|GO|eSLDB|GO|Organelle|GO|eSLDB|GO|PA-GOSUB|GO|GO|GO|GO|Organelle|GO|GO|GO|GO|GO|MatrixDB|GO|eSLDB|GO|GO|Organelle|GO|Organelle|GO	BioGRID|HPRD	9606
P49755	Transmembrane emp24 domain-containing protein 10	UniProtKB/Swiss-Prot/P	Cytosol(0.8)|Secretory-pathway(1)|Extracellular(0.8)|Membrane(0.999)	GO:0012505|GO:0005783|GO:0005789|GO:0005793|GO:0033116|GO:0005794|GO:0005794|GO:0005794|GO:0005794|GO:0000139|GO:0030137|GO:0005801|GO:0042470|GO:0030667|GO:0042589|GO:0012507|GO:0030133|GO:0030140|GO:0005576|GO:0016021|GO:0016021|GO:0005886|GO:0005886|GO:0070765	Experimental: experimental|Experimental: inferred from direct assay|Unknown: traceable author statement|Experimental: inferred from direct assay|Unknown: traceable author statement|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Experimental: annotated protein expression (APE)|Unknown: traceable author statement|Predicted: inferred from sequence or structural similarity|Predicted: inferred from sequence or structural similarity|Unknown: inferred from electronic annotation|Predicted: inferred from sequence or structural similarity|Predicted: inferred from sequence or structural similarity|Unknown: traceable author statement|Unknown: traceable author statement|Predicted: inferred from sequence or structural similarity|Experimental: experimental|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Predicted: inferred from sequence or structural similarity|Experimental: experimental|Experimental: inferred from direct assay	Organelle|GO|GO|GO|GO|eSLDB|GO|PA-GOSUB|The Human Protein Atlas|GO|GO|GO|GO|GO|GO|GO|GO|GO|MatrixDB|eSLDB|GO|GO|Organelle|GO	HPRD|IntAct	9606
Q96BI3	Gamma-secretase subunit APH-1A	UniProtKB/Swiss-Prot/P	Secretory-pathway(1)|Extracellular(0.8)|Membrane(0.999)	GO:0005783|GO:0005783|GO:0005789|GO:0005794|GO:0005794|GO:0005794|GO:0032580|GO:0005576|GO:0016020|GO:0016021|GO:0016021|GO:0005886|GO:0070765|GO:0005887	Experimental: experimental|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: inferred from direct assay|Predicted: PAML algorithm|Unknown: inferred from electronic annotation|Experimental: experimental|Unknown: HDA|Experimental: experimental|Experimental: inferred from direct assay|Unknown: traceable author statement|Experimental: inferred from direct assay|Experimental: inferred from direct assay	eSLDB|GO|GO|eSLDB|GO|PA-GOSUB|GO|MatrixDB|GO|eSLDB|GO|GO|GO|GO	HPRD|IntAct|BioGRID	9606
Q92542	Nicastrin	UniProtKB/Swiss-Prot/P	Cytosol(0.902)|Nucleus(0.8)|Secretory-pathway(0.999)|Extracellular(0.8)|Membrane(0.999)	GO:0005829|GO:0005634|GO:0005783|GO:0005783|GO:0005783|GO:0005794|GO:0005794|GO:0005765|GO:0042470|GO:0005576|GO:0016020|GO:0016021|GO:0016021|GO:0005886|GO:0005886|GO:0070765|GO:0005887|GO:0070062|GO:0005925	Experimental: annotated protein expression (APE)|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Experimental: experimental|Experimental: experimental|Predicted: inferred from sequence or structural similarity|Predicted: pTarget method|Unknown: HDA|Unknown: inferred from electronic annotation|Experimental: experimental|Unknown: HDA|Predicted: SVM decision tree|Unknown: non-traceable author statement|Unknown: traceable author statement|Experimental: experimental|Experimental: inferred from direct assay|Predicted: inferred from sequence or structural similarity|Unknown: HDA|Unknown: HDA	The Human Protein Atlas|Human Proteinpedia|GO|Human Proteinpedia|Organelle|GO|LOCATE|GO|GO|MatrixDB|GO|eSLDB|GO|GO|Organelle|GO|GO|GO|GO	HPRD|IntAct|BioGRID	9606
O94905	Erlin-2	UniProtKB/Swiss-Prot/P	Secretory-pathway(1)|Cytosol(0.8)|Nucleus(0.8)|Extracellular(0.8)|Membrane(0.994)	GO:secretory_pathway|GO:0005829|GO:0032991|GO:0005783|GO:0005783|GO:0005783|GO:0005789|GO:0005576|GO:0016020|GO:0016021|GO:0045121|GO:0005886	Predicted: SVM decision tree|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: inferred from direct assay|Experimental: experimental|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Experimental: experimental|Experimental: experimental|Unknown: inferred from electronic annotation|Experimental: inferred from direct assay|Experimental: inferred from direct assay	eSLDB|GO|GO|GO|Human Proteinpedia|The Human Protein Atlas|GO|MatrixDB|eSLDB|GO|GO|GO	BioGRID	9606
Q8WW43	Gamma-secretase subunit APH-1B	UniProtKB/Swiss-Prot/P	Secretory-pathway(0.988)|Extracellular(0.8)|Membrane(0.996)	GO:0005783|GO:0005783|GO:0030133|GO:0005576|GO:0016021|GO:0016021|GO:0005886|GO:0070765|GO:0005887	Predicted: inferred from biological aspect of ancestor|Experimental: experimental|Experimental: inferred from direct assay|Experimental: experimental|Predicted: SVM decision tree|Experimental: inferred from direct assay|Unknown: traceable author statement|Predicted: inferred from biological aspect of ancestor|Predicted: inferred from biological aspect of ancestor	GO|Human Proteinpedia|GO|MatrixDB|eSLDB|GO|GO|GO|GO	BioGRID	9606
P07204	Thrombomodulin	UniProtKB/Swiss-Prot/P	Membrane(0.999)|Cytosol(0.86)|Nucleus(0.8)|Extracellular(0.958)	GO:0009986|GO:0005829|GO:0005654|GO:0005774|GO:0005576|GO:0005576|GO:0005615|GO:0016020|GO:0016021|GO:0005886|GO:0005886|GO:0016327|GO:0005887	Experimental: inferred from direct assay|Experimental: annotated protein expression (APE)|Experimental: annotated protein expression (APE)|Unknown: inferred from electronic annotation|Experimental: experimental|Predicted: PAML algorithm|Unknown: inferred from electronic annotation|Experimental: experimental|Experimental: experimental|Unknown: traceable author statement|Experimental: experimental|Unknown: inferred from electronic annotation|Unknown: inferred from electronic annotation	GO|The Human Protein Atlas|The Human Protein Atlas|GO|MatrixDB|PA-GOSUB|GO|MatrixDB|eSLDB|GO|Organelle|GO|GO	BioGRID|IntAct	9606
Q12908	Ileal sodium/bile acid cotransporter	UniProtKB/Swiss-Prot/P	Membrane(0.999)|Extracellular(0.8)	GO:0005902|GO:0005576|GO:0016021|GO:0005886|GO:0005886|GO:0005886|GO:0005886|GO:0005887|GO:0016324	Unknown: inferred from electronic annotation|Experimental: experimental|Predicted: SVM decision tree|Unknown: traceable author statement|Predicted: pTarget method|Experimental: experimental|Predicted: PAML algorithm|Unknown: traceable author statement|Unknown: inferred from electronic annotation	GO|MatrixDB|eSLDB|GO|LOCATE|Organelle|PA-GOSUB|GO|GO	IntAct	9606
Q3KNW5	Solute carrier family 10 member 6	UniProtKB/Swiss-Prot/P	Extracellular(0.8)|Membrane(0.987)	GO:0005576|GO:0016021|GO:0016021|GO:0005886|GO:0005886|GO:0005886	Experimental: experimental|Predicted: SVM decision tree|Unknown: inferred from electronic annotation|Unknown: traceable author statement|Predicted: pTarget method|Predicted: PAML algorithm	MatrixDB|eSLDB|GO|GO|LOCATE|PA-GOSUB	IntAct	9606
O43889	Cyclic AMP-responsive element-binding protein 3	UniProtKB/Swiss-Prot/P	Cytosol(0.988)|Nucleus(0.971)|Secretory-pathway(0.902)|Extracellular(0.8)|Membrane(0.3)	GO:0005737|GO:0005829|GO:0005829|GO:0005634|GO:0005634|GO:0005634|GO:0005654|GO:0005783|GO:0005789|GO:0000139|GO:0005576|GO:0016021	Predicted: SVM decision tree|Experimental: inferred from direct assay|Experimental: annotated protein expression (APE)|Unknown: inferred by curator|Experimental: experimental|Predicted: PAML algorithm|Unknown: traceable author statement|Experimental: inferred from direct assay|Unknown: inferred from electronic annotation|Unknown: traceable author statement|Experimental: experimental|Unknown: inferred from electronic annotation	eSLDB|GO|The Human Protein Atlas|GO|Organelle|PA-GOSUB|GO|GO|GO|GO|MatrixDB|GO	BioGRID|IntAct	9606
P02792	Ferritin light chain	UniProtKB/Swiss-Prot/P	Cytosol(0.994)|Secretory-pathway(0.3)|Extracellular(0.86)|Membrane(0.86)	GO:0005737|GO:0005829|GO:0005829|GO:0008043|GO:0035578|GO:0005576|GO:0005576|GO:0016020|GO:0016020|GO:0070062	Predicted: SVM decision tree|Unknown: traceable author statement|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Unknown: traceable author statement|Unknown: traceable author statement|Experimental: experimental|Unknown: HDA|Experimental: experimental|Unknown: HDA	eSLDB|GO|The Human Protein Atlas|GO|GO|GO|MatrixDB|GO|MatrixDB|GO	IntAct	9606
A4D1B5	Gamma-secretase-activating protein	UniProtKB/Swiss-Prot/P	Cytosol(0.94)|Secretory-pathway(0.8)|Membrane(0.7)	GO:0005737|GO:0043231|GO:0005802|GO:0016021	Predicted: SVM decision tree|Experimental: annotated protein expression (APE)|Experimental: inferred from direct assay|Predicted: SVM decision tree	eSLDB|The Human Protein Atlas|GO|eSLDB	BioGRID	9606
A0A0S2Z4D2	Presenilin	UniProtKB/TrEmbl/P	Extracellular(0.8)	GO:0005576	Experimental: experimental	MatrixDB	BioGRID	9606
A0A024R6A3	Presenilin	UniProtKB/TrEmbl/P	Extracellular(0.8)	GO:0005576	Experimental: experimental	MatrixDB	BioGRID	9606