What is ComPPI?
Protein-protein interaction networks are spatially and temporally merged from the results of various experimental and predicting methods. These often ignore localization data, which in turn deteriorates the data quality and its predictive potential.
We present ComPPI, the compartmentalized protein-protein interaction database, which provides qualitative information on the interactions, proteins and their localizations integrated from multiple databases for protein-protein interaction network analysis.
The overlap of the data among various databases can be very low (1), therefore the integration extended with manual curation protocols results in improved data quality.
The subcellular localizations of the interacting proteins are often not taken into consideration, leading to networks with many biologically unlikely interactions. Creating a consensus between the available interaction and localization data further improves the data quality.
ComPPI introduces two novel quantitative scores, the Localization Score and the Interaction Score, which describe the calculated probability of the data correctness.
ComPPI is a novel, integrative, open source database useful for the analysis of experimental results in biochemistry, molecular biology and proteomics as well as for proteome- and interactome-wide studies in bioinformatics and network science helping cellular biology, medicine and drug design.