O16850

Forkhead box protein O    //   UniProt Profile 

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Species

 C. elegans

Number of Interactions

 27 / 28

Average Interaction Score

 0.807

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

O16850

Interaction Score
0.998

Q21921

(UniProtKB/Swiss-Prot/P) Details

NAD-dependent protein deacetylase sir-2.1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear chromosome, telomeric region (GO:0000784) 0.988 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.998

Q17941

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase akt-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 0.982 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular (GO:0005622) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Dendrite (GO:0030425) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Axon (GO:0030424) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.992 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.997

Q18825

(UniProtKB/Swiss-Prot/P) Details

Beta-catenin/armadillo-related protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Cell junction (GO:0030054) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Cell-cell adherens junction (GO:0005913) 0.992 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.982

Q9XWK6

(UniProtKB/TrEmbl/P) Details

SUPpressor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.974

Q9N5V3

(UniProtKB/TrEmbl/P) Details

IMportin Beta family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear periphery (GO:0034399) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

CCSB, IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.961

Q9XTG7

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase akt-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular (GO:0005622) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.96

Q9U1W2

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 8

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Srb-mediator complex (GO:0016592) 0.79 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.948

Q2PJ68

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase sgk-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.939

Q9U226

(UniProtKB/TrEmbl/P) Details

TAF (TBP-associated transcription factor) family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Transcription factor TFIID complex (GO:0005669) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus SAGA complex (GO:0000124) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus SLIK (SAGA-like) complex (GO:0046695) 0.999 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.937

Q09228

(UniProtKB/Swiss-Prot/P) Details

Egg-laying defective protein 27

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus NuRD complex (GO:0016581) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

DIP, IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.926

Q9XVN4

(UniProtKB/TrEmbl/P) Details

C. Elegans Homeobox

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.926

Q19418

(UniProtKB/TrEmbl/P) Details

Zinc finger putative Transcription Factor family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.901

Q9NA56

(UniProtKB/Swiss-Prot/P) Details

Putative T-box protein 39

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.958 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.895

O45962

(UniProtKB/Swiss-Prot/P) Details

Regulation of longevity by E3 ubiquitin-protein ligase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.884

Q17381

(UniProtKB/Swiss-Prot/P) Details

Defective pharyngeal development protein 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.881

Q18299

(UniProtKB/TrEmbl/P) Details

Nuclear Hormone Receptor family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.937 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.855

A5JYW9

(UniProtKB/Swiss-Prot/P) Details

Paired amphipathic helix protein sin-3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Sin3 complex (GO:0016580) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.752

G5EFF5

(UniProtKB/Swiss-Prot/P) Details

Nuclear hormone receptor family member daf-12

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.752

G5EEM0

(UniProtKB/TrEmbl/P) Details

Nuclear Hormone Receptor family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.743

O17917

(UniProtKB/Swiss-Prot/P) Details

RING finger protein 113 homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.79 Unknown: HDA GO PubMed 
Nucleus U2-type spliceosomal complex (GO:0005684) 0.79 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.743

Q6BER5

(UniProtKB/Swiss-Prot/P) Details

Nucleosome-remodeling factor subunit NURF301-like

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to membrane (GO:0016021) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.692

O76368

(UniProtKB/Swiss-Prot/P) Details

Putative cuticle collagen 99

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Collagen (GO:0005581) 0.958 Unknown: non-traceable author statement GO PubMed 
Membrane Fully spanning plasma membrane (GO:0044214) 0.96 Experimental: inferred from direct assay GO PubMed 
Membrane Neuromuscular junction (GO:0031594) 0.96 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.658

O62259

(UniProtKB/TrEmbl/P) Details

Kruppel-Like Factor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to membrane (GO:0016021) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.634

Q22826

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.282

H2KZU4

(UniProtKB/TrEmbl/P) Details

Nuclear Hormone Receptor family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.282

H2KZI6

(UniProtKB/TrEmbl/P) Details

Zinc Finger Protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O16850

Interaction Score
0.282

G5ED66

(UniProtKB/TrEmbl/P) Details

PAX (Paired box) transcription factor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015