O45734

CathePsin L family    //   UniProt Profile 

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Species

 C. elegans

Number of Interactions

 15 / 19

Average Interaction Score

 0.901

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Yolk granule (GO:0042718) 0.996 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Lysosome (GO:0005764) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Lysosome (GO:0005764) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Vesicle lumen (GO:0031983) 0.996 Experimental: inferred from direct assay GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

O45734

Interaction Score
0.999

Q18115

(UniProtKB/Swiss-Prot/P) Details

26S proteasome non-ATPase regulatory subunit 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Proteasome storage granule (GO:0034515) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cell cortex (GO:0005938) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Proteasome regulatory particle, base subcomplex (GO:0008540) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Mitotic spindle (GO:0072686) 0.999 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.94 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

O45734

Interaction Score
0.998

Q9U9Y8

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine kinase NLK

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cell cortex (GO:0005938) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.996

Q22227

(UniProtKB/Swiss-Prot/P) Details

Segment polarity protein dishevelled homolog mig-5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cell cortex (GO:0005938) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.51 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct, DIP, BioGRID

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.995

P34529

(UniProtKB/Swiss-Prot/P) Details

Endoribonuclease dcr-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol RNA-induced silencing complex (GO:0016442) 0.988 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct, DIP, BioGRID

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.993

Q10953

(UniProtKB/Swiss-Prot/P) Details

Armadillo repeat-containing protein wrm-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cell cortex (GO:0005938) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.978

Q19713

(UniProtKB/Swiss-Prot/P) Details

Phenylalanine--tRNA ligase beta subunit

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.982 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Phenylalanine-tRNA ligase complex (GO:0009328) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

O45734

Interaction Score
0.957

O17583

(UniProtKB/Swiss-Prot/P) Details

Protein lin-10

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.96 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi cisterna membrane (GO:0032580) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Golgi trans cisterna (GO:0000138) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Trans-Golgi network transport vesicle (GO:0030140) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Neuron projection (GO:0043005) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Dendrite (GO:0030425) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Cell junction (GO:0030054) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Synapse (GO:0045202) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.952

Q9XXN3

(UniProtKB/Swiss-Prot/P) Details

Nuclear envelope phosphatase-regulatory subunit 1 homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Nem1-Spo7 phosphatase complex (GO:0071595) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.7 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.926

Q27481

(UniProtKB/TrEmbl/P) Details

UBA (Human ubiquitin) related

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.85

P30642

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic translation initiation factor 3 subunit D

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Eukaryotic 48S preinitiation complex (GO:0033290) 0.853 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Eukaryotic 43S preinitiation complex (GO:0016282) 0.853 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Eukaryotic translation initiation factor 3 complex (GO:0005852) 0.853 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

DIP, BioGRID, IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.846

P54936

(UniProtKB/Swiss-Prot/P) Details

Protein lin-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.86 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.846

O18301

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.787

Q19325

(UniProtKB/Swiss-Prot/P) Details

Sister chromatid cohesion protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.995 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.995 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear cohesin complex (GO:0000798) 0.995 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Cohesin complex (GO:0008278) 0.995 Predicted: inferred from physical interaction GO PubMed 

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

O45734

Interaction Score
0.697

Q564T0

(UniProtKB/TrEmbl/P) Details

GOlgi-associated PDZ and Coiled-coil motif protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Plasma membrane (GO:0005886) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

CCSB

Interaction Source Publication:

PubMed 

O45734

Interaction Score
0.697

O18302

(UniProtKB/TrEmbl/P) Details

GOlgi-associated PDZ and Coiled-coil motif protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct, CCSB, DIP

Interaction Source Publication:

PubMed , PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015