P22455

Fibroblast growth factor receptor 4 // UniProt Profile

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Species	H. sapiens
Number of Interactions	61 / 73
Average Interaction Score	0.742

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P22455

Interaction Score

P54764

(UniProtKB/Swiss-Prot/P) Details

Ephrin type-A receptor 4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.79	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.853	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Filopodium (GO:0030175)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite (GO:0030425)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Nerve terminal (GO:0043679)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axonal growth cone (GO:0044295)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed

P22455

Interaction Score

P19022

(UniProtKB/Swiss-Prot/P) Details

Cadherin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.3	Unknown: traceable author statement	GO	PubMed
Cytosol	Cortical actin cytoskeleton (GO:0030864)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.988	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Sarcolemma (GO:0042383)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Catenin complex (GO:0016342)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell-cell adherens junction (GO:0005913)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Fascia adherens (GO:0005916)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Intercalated disc (GO:0014704)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P22455

Interaction Score

P50281

(UniProtKB/Swiss-Prot/P) Details

Matrix metalloproteinase-14

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.98	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Macropinosome (GO:0044354)	0.98	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.98	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.998	Experimental: inferred from mutant phenotype	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

DIP, IntAct

Interaction Source Publication:

PubMed

P22455

Interaction Score

Q15256

(UniProtKB/Swiss-Prot/P) Details

Receptor-type tyrosine-protein phosphatase R

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P22455

Interaction Score

Q9H3N1

(UniProtKB/Swiss-Prot/P) Details

Thioredoxin-related transmembrane protein 1

P22455

Interaction Score

0.999

Q6ZMH5

(UniProtKB/Swiss-Prot/P) Details

Zinc transporter ZIP5

P22455

Interaction Score

0.998

Q96G30

(UniProtKB/Swiss-Prot/P) Details

Melanocortin-2 receptor accessory protein 2

P22455

Interaction Score

0.996

O95661

(UniProtKB/Swiss-Prot/P) Details

GTP-binding protein Di-Ras3

P22455

Interaction Score

0.996

O94923

(UniProtKB/Swiss-Prot/P) Details

D-glucuronyl C5-epimerase

P22455

Interaction Score

0.995

P10767

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 6

P22455

Interaction Score

0.995

P21781

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 7

P22455

Interaction Score

0.994

Q9BY76

(UniProtKB/Swiss-Prot/P) Details

Angiopoietin-related protein 4

P22455

Interaction Score

0.994

P31371

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 9

P22455

Interaction Score

0.994

Q08209

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Calcineurin complex (GO:0005955)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	0.98	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Sarcolemma (GO:0042383)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.98	Experimental: inferred from direct assay	GO	PubMed
Membrane	Slit diaphragm (GO:0036057)	0.98	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P22455

Interaction Score

0.993

O60258

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 17

P22455

Interaction Score

0.993

O76093

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 18

P22455

Interaction Score

0.992

Q96QR1

(UniProtKB/Swiss-Prot/P) Details

Secretoglobin family 3A member 1

P22455

Interaction Score

0.992

O95750

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 19

P22455

Interaction Score

0.992

Q9Y5W5

(UniProtKB/Swiss-Prot/P) Details

Wnt inhibitory factor 1

P22455

Interaction Score

0.992

P55899

(UniProtKB/Swiss-Prot/P) Details

IgG receptor FcRn large subunit p51

P22455

Interaction Score

0.992

P05230

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

HPRD, BioGRID, DIP, IntAct

Interaction Source Publication:

PubMed

, PubMed

P22455

Interaction Score

0.989

P12034

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 5

P22455

Interaction Score

0.989

P14618

(UniProtKB/Swiss-Prot/P) Details

Pyruvate kinase PKM

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Photoreceptor inner segment (GO:0001917)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Myelin sheath (GO:0043209)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Cilium (GO:0005929)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.902	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.902	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.902	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.931	Experimental: experimental	MatrixDB	PubMed
Cytosol	Vesicle (GO:0031982)	1	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P22455

Interaction Score

0.988

P08620

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 4

P22455

Interaction Score

0.987

O00220

(UniProtKB/Swiss-Prot/P) Details

Tumor necrosis factor receptor superfamily member 10A

P22455

Interaction Score

0.986

P55075

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 8

P22455

Interaction Score

0.982

P29350

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein phosphatase non-receptor type 6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Alpha-beta T cell receptor complex (GO:0042105)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Organelle	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.931	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.931	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.931	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P22455

Interaction Score

0.981

P11487

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 3

P22455

Interaction Score

0.98

Q96S79

(UniProtKB/Swiss-Prot/P) Details

Ras-like protein family member 10B

P22455

Interaction Score

0.97

P09038

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor 2

P22455

Interaction Score

0.969

Q3MIR4

(UniProtKB/Swiss-Prot/P) Details

Cell cycle control protein 50B

P22455

Interaction Score

0.94

Q8NBG6

(UniProtKB/TrEmbl/P) Details

Fibroblast growth factor

P22455

Interaction Score

0.935

Q13296

(UniProtKB/Swiss-Prot/P) Details

Mammaglobin-A

P22455

Interaction Score

0.92

Q16089

(UniProtKB/TrEmbl/P) Details

Fibroblast growth factor 1

P22455

Interaction Score

0.91

P42224

(UniProtKB/Swiss-Prot/P) Details

Signal transducer and activator of transcription 1-alpha/beta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P22455

Interaction Score

0.906

Q9UJM3

(UniProtKB/Swiss-Prot/P) Details

ERBB receptor feedback inhibitor 1

P22455

Interaction Score

0.902

Q05209

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein phosphatase non-receptor type 12

P22455

Interaction Score

0.8

A8K147

(UniProtKB/TrEmbl/P) Details

Multifunctional fusion protein

P22455

Interaction Score

0.8

Q96KN1

(UniProtKB/Swiss-Prot/P) Details

Protein FAM84B

P22455

Interaction Score

0.8

Q96JY6

(UniProtKB/Swiss-Prot/P) Details

PDZ and LIM domain protein 2

P22455

Interaction Score

0.79

P40763

(UniProtKB/Swiss-Prot/P) Details

Signal transducer and activator of transcription 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Unknown: inferred by curator	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.79	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P22455

Interaction Score

0.782

P50750

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinase 9

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	PML body (GO:0016605)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcription elongation factor complex (GO:0008023)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Positive transcription elongation factor complex b (GO:0008024)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

P22455

Interaction Score

0.7

Q96J88

(UniProtKB/Swiss-Prot/P) Details

Epithelial-stromal interaction protein 1

P22455

Interaction Score

0.7

Q7Z2V8

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686K0257

P22455

Interaction Score

0.699

Q96JM4

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat and IQ domain-containing protein 1

P22455

Interaction Score

0.688

B4DVP5

(UniProtKB/TrEmbl/P) Details

Fibroblast growth factor receptor

P22455

Interaction Score

0.688

J3KPQ0

(UniProtKB/TrEmbl/P) Details

Fibroblast growth factor receptor

P22455

Interaction Score

0.688

A0A0S2Z4C6

(UniProtKB/TrEmbl/P) Details

Serine/threonine-protein phosphatase

P22455

Interaction Score

0.602

Q6NX70

(UniProtKB/TrEmbl/P) Details

Mammaglobin-A

P22455

Interaction Score

0.3

O15234

(UniProtKB/Swiss-Prot/P) Details

Protein CASC3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.931	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasmic stress granule (GO:0010494)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.931	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Exon-exon junction complex (GO:0035145)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

P22455

Interaction Score

Q4LE43

(UniProtKB/TrEmbl/P) Details

Phosphoinositide phospholipase C

P22455

Interaction Score

Q8IZY5

(UniProtKB/Swiss-Prot/P) Details

BH3-like motif-containing cell death inducer

P22455

Interaction Score

D6W5A2

(UniProtKB/TrEmbl/P) Details

Metastasis associated 1 family, member 3, isoform CRA_a

P22455

Interaction Score

Q9BTC8

(UniProtKB/Swiss-Prot/P) Details

Metastasis-associated protein MTA3

P22455

Interaction Score

Q9UJX0

(UniProtKB/Swiss-Prot/P) Details

Oxidative stress-induced growth inhibitor 1

P22455

Interaction Score

K7ERB6

(UniProtKB/TrEmbl/P) Details

Homologous-pairing protein 2 homolog

P22455

Interaction Score

Q9P2W1

(UniProtKB/Swiss-Prot/P) Details

Homologous-pairing protein 2 homolog

P22455

Interaction Score

Q5VTR2

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase BRE1A

P22455

Interaction Score

Q92748

(UniProtKB/Swiss-Prot/P) Details

Thyroid hormone-inducible hepatic protein

P22455

Interaction Score

Q9BZ95

(UniProtKB/Swiss-Prot/P) Details

Histone-lysine N-methyltransferase NSD3

P22455

Interaction Score

Q06124

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein phosphatase non-receptor type 11

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.999	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

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P22455

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P22455

P54764

Ephrin type-A receptor 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

P19022

Cadherin-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

P50281

Matrix metalloproteinase-14

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

Q15256

Receptor-type tyrosine-protein phosphatase R

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

Q9H3N1

Thioredoxin-related transmembrane protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

Q6ZMH5

Zinc transporter ZIP5

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

Q96G30

Melanocortin-2 receptor accessory protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

O95661

GTP-binding protein Di-Ras3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

O94923

D-glucuronyl C5-epimerase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

P10767

Fibroblast growth factor 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

P21781

Fibroblast growth factor 7

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455

Q9BY76

Angiopoietin-related protein 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

P22455