P34604

Probable translation initiation factor eIF-2B subunit alpha    //   UniProt Profile 

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Species

 C. elegans

Number of Interactions

 25 / 29

Average Interaction Score

 0.602

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P34604

Interaction Score
0.907

Q22227

(UniProtKB/Swiss-Prot/P) Details

Segment polarity protein dishevelled homolog mig-5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cell cortex (GO:0005938) 0.996 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.51 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct, DIP, BioGRID

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.907

Q19969

(UniProtKB/Swiss-Prot/P) Details

Importin subunit alpha-3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear pore (GO:0005643) 0.999 Experimental: inferred from mutant phenotype GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, DIP, BioGRID

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.899

Q18825

(UniProtKB/Swiss-Prot/P) Details

Beta-catenin/armadillo-related protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Cell junction (GO:0030054) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Cell-cell adherens junction (GO:0005913) 0.992 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.899

Q10953

(UniProtKB/Swiss-Prot/P) Details

Armadillo repeat-containing protein wrm-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cell cortex (GO:0005938) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.885

Q9GYS8

(UniProtKB/TrEmbl/P) Details

Phenylalanyl Amino-acyl tRNA Synthetase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Phenylalanine-tRNA ligase complex (GO:0009328) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.872

O44156

(UniProtKB/Swiss-Prot/P) Details

Proteasome subunit alpha type-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Proteasome core complex, alpha-subunit complex (GO:0019773) 0.958 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

CCSB, IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed , PubMed 

P34604

Interaction Score
0.872

P34286

(UniProtKB/Swiss-Prot/P) Details

Proteasome subunit beta type-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Proteasome core complex, beta-subunit complex (GO:0019774) 0.958 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.855

G5EFA2

(UniProtKB/Swiss-Prot/P) Details

Chromosomal passenger complex protein bir-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Midbody (GO:0030496) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Spindle midzone (GO:0051233) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Condensed chromosome (GO:0000793) 0.94 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.828

Q17868

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinases regulatory subunit

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol SCF ubiquitin ligase complex (GO:0019005) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cyclin-dependent protein kinase holoenzyme complex (GO:0000307) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.79 Unknown: inferred by curator GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.828

Q86B36

(UniProtKB/TrEmbl/P) Details

Phenylalanyl Amino-acyl tRNA Synthetase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.728

G5EEK8

(UniProtKB/TrEmbl/P) Details

Calcium-transporting ATPase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Sarcoplasmic reticulum (GO:0016529) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.8 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Nuclear outer membrane-endoplasmic reticulum membrane network (GO:0042175) 0.992 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.637

Q22174

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct, DIP, CCSB, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.637

Q09485

(UniProtKB/Swiss-Prot/P) Details

43 kDa receptor-associated protein of the synapse homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Synapse (GO:0045202) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct, DIP, CCSB

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.637

O76368

(UniProtKB/Swiss-Prot/P) Details

Putative cuticle collagen 99

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Collagen (GO:0005581) 0.958 Unknown: non-traceable author statement GO PubMed 
Membrane Fully spanning plasma membrane (GO:0044214) 0.96 Experimental: inferred from direct assay GO PubMed 
Membrane Neuromuscular junction (GO:0031594) 0.96 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.637

P34509

(UniProtKB/Swiss-Prot/P) Details

Uncharacterized protein K06H7.1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.637

G5EDF7

(UniProtKB/Swiss-Prot/P) Details

Dual specificity mitogen-activated protein kinase kinase sek-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.637

Q86NC2

(UniProtKB/TrEmbl/P) Details

NADH Ubiquinone Oxidoreductase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.982 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrial respiratory chain complex I (GO:0005747) 0.982 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.637

Q09601

(UniProtKB/Swiss-Prot/P) Details

Nucleoporin NUP35

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.997 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.997 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear pore (GO:0005643) 0.997 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear pore central transport channel (GO:0044613) 0.997 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nuclear pore nuclear basket (GO:0044615) 0.997 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0.637

P54936

(UniProtKB/Swiss-Prot/P) Details

Protein lin-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.86 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0.464

P34692

(UniProtKB/Swiss-Prot/P) Details

UPF0183 protein T01G9.2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.51 Unknown: HDA GO PubMed 
Cytosol Striated muscle dense body (GO:0055120) 0.51 Unknown: HDA GO PubMed 

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0

P34420

(UniProtKB/Swiss-Prot/P) Details

Splicing factor ESS-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.988 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct, CCSB, DIP, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0

Q10051

(UniProtKB/Swiss-Prot/P) Details

Pre-mRNA-processing factor 19

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Prp19 complex (GO:0000974) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Nucleus U2-type catalytic step 1 spliceosome (GO:0071006) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, DIP

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0

Q9XVV3

(UniProtKB/Swiss-Prot/P) Details

Nuclear hormone receptor family member nhr-67

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.988 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID, IntAct, DIP

Interaction Source Publication:

PubMed 

P34604

Interaction Score
0

Q20351

(UniProtKB/Swiss-Prot/P) Details

Putative protein-tyrosine sulfotransferase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
N/A Cellular component (GO:0005575) 0.3 Unknown: no biological data available GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34604

Interaction Score
0

Q9XU13

(UniProtKB/TrEmbl/P) Details

Calcium-transporting ATPase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Plasma membrane (GO:0005886) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015