Q0IIN1

Keratin 77 // UniProt Profile

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Species	H. sapiens
Number of Interactions	22 / 32
Average Interaction Score	0.806

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.8	Experimental: experimental	Human Proteinpedia	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q0IIN1

Interaction Score

0.979

P35908

(UniProtKB/Swiss-Prot/P) Details

Keratin, type II cytoskeletal 2 epidermal

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cornified envelope (GO:0001533)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intermediate filament (GO:0005882)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Keratin filament (GO:0045095)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q0IIN1

Interaction Score

0.968

P13645

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 10

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cornified envelope (GO:0001533)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament (GO:0005882)	1	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q0IIN1

Interaction Score

0.968

P04264

(UniProtKB/Swiss-Prot/P) Details

Keratin, type II cytoskeletal 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cornified envelope (GO:0001533)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Keratin filament (GO:0045095)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.99	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.99	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.99	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.99	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q0IIN1

Interaction Score

0.961

Q93034

(UniProtKB/Swiss-Prot/P) Details

Cullin-5

Q0IIN1

Interaction Score

0.96

O60285

(UniProtKB/Swiss-Prot/P) Details

NUAK family SNF1-like kinase 1

Q0IIN1

Interaction Score

0.959

Q9H0W5

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 8

Q0IIN1

Interaction Score

0.953

Q96GG9

(UniProtKB/Swiss-Prot/P) Details

DCN1-like protein 1

Q0IIN1

Interaction Score

0.949

P46108

(UniProtKB/Swiss-Prot/P) Details

Adapter molecule crk

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.978	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.978	Unknown: inferred by curator	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.978	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.978	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Experimental: experimental	Organelle	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.958	Predicted: inferred from physical interaction	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.978	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.971	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.978	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q0IIN1

Interaction Score

0.939

Q96CW1

(UniProtKB/Swiss-Prot/P) Details

AP-2 complex subunit mu

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.928	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.928	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.928	Unknown: traceable author statement	GO	PubMed
Cytosol	Endolysosome membrane (GO:0036020)	0.928	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.657	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle (GO:0045334)	0.657	Unknown: non-traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.657	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	AP-2 adaptor complex (GO:0030122)	0.972	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.928	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q0IIN1

Interaction Score

0.937

P19012

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 15

Q0IIN1

Interaction Score

0.936

P29353

(UniProtKB/Swiss-Prot/P) Details

SHC-transforming protein 1

Q0IIN1

Interaction Score

0.928

Q9NQC7

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase CYLD

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Spindle (GO:0005819)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cilium basal body (GO:0036064)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic microtubule (GO:0005881)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Extrinsic to internal side of plasma membrane (GO:0031234)	0.96	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q0IIN1

Interaction Score

0.909

Q9UBC1

(UniProtKB/Swiss-Prot/P) Details

NF-kappa-B inhibitor-like protein 1

Q0IIN1

Interaction Score

0.906

Q70EK8

(UniProtKB/Swiss-Prot/P) Details

Inactive ubiquitin carboxyl-terminal hydrolase 53

Q0IIN1

Interaction Score

0.87

C9JVE2

(UniProtKB/TrEmbl/P) Details

DCN1-like protein

Q0IIN1

Interaction Score

0.806

Q5STV6

(UniProtKB/TrEmbl/P) Details

NF-kappa-B inhibitor-like protein 1

Q0IIN1

Interaction Score

0.806

A0A0A0MRT5

(UniProtKB/TrEmbl/P) Details

NF-kappa-B inhibitor-like protein 1

Q0IIN1

Interaction Score

0.799

Q15323

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha1

Q0IIN1

Interaction Score

0.64

Q9BXB1

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat-containing G-protein coupled receptor 4

Q0IIN1

Interaction Score

0.56

Q9H9I0

(UniProtKB/TrEmbl/P) Details

cDNA FLJ12737 fis, clone NT2RP2000337

Q0IIN1

Interaction Score

Q59ER8

(UniProtKB/TrEmbl/P) Details

Leucine-rich repeat-containing G protein-coupled receptor 4 variant

Q0IIN1

Interaction Score

E9PFW3

(UniProtKB/TrEmbl/P) Details

AP-2 complex subunit mu

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Q0IIN1

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q0IIN1

P35908

Keratin, type II cytoskeletal 2 epidermal

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

P13645

Keratin, type I cytoskeletal 10

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

P04264

Keratin, type II cytoskeletal 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

Q93034

Cullin-5

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

O60285

NUAK family SNF1-like kinase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

Q9H0W5

Coiled-coil domain-containing protein 8

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

Q96GG9

DCN1-like protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

P46108

Adapter molecule crk

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

Q96CW1

AP-2 complex subunit mu

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

P19012

Keratin, type I cytoskeletal 15

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

P29353

SHC-transforming protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1

Q9NQC7

Ubiquitin carboxyl-terminal hydrolase CYLD

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q0IIN1