Q59FG5

Patched variant // UniProt Profile

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Species	H. sapiens
Number of Interactions	6 / 7
Average Interaction Score	0.48

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Integral to membrane (GO:0016021)	0.7	Predicted: SVM decision tree	eSLDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q59FG5

Interaction Score

0.7

Q99835

(UniProtKB/Swiss-Prot/P) Details

Smoothened homolog

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.86	Unknown: traceable author statement	GO	PubMed
Membrane	Cilium (GO:0005929)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cilium membrane (GO:0060170)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Caveola (GO:0005901)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q59FG5

Interaction Score

0.698

Q15465

(UniProtKB/Swiss-Prot/P) Details

Sonic hedgehog protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.86	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.997	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.3	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.997	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.997	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.997	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.997	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q59FG5

Interaction Score

0.672

Q14623

(UniProtKB/Swiss-Prot/P) Details

Indian hedgehog protein

Q59FG5

Interaction Score

0.602

O43323

(UniProtKB/Swiss-Prot/P) Details

Desert hedgehog protein

Q59FG5

Interaction Score

0.21

P14635

(UniProtKB/Swiss-Prot/P) Details

G2/mitotic-specific cyclin-B1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Condensed nuclear chromosome outer kinetochore (GO:0000942)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q59FG5

Interaction Score

Q9H2X6

(UniProtKB/Swiss-Prot/P) Details

Homeodomain-interacting protein kinase 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.982	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.982	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PML body (GO:0016605)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

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Q59FG5

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q59FG5

Q99835

Smoothened homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q59FG5

Q15465

Sonic hedgehog protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q59FG5

Q14623

Indian hedgehog protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q59FG5

O43323

Desert hedgehog protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q59FG5

P14635

G2/mitotic-specific cyclin-B1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q59FG5

Q9H2X6

Homeodomain-interacting protein kinase 2

Localizations:

Interaction Source Database:

Interaction Source Publication: