Q9Y4F9

Rho family-interacting cell polarization regulator 2 // UniProt Profile

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Species	H. sapiens
Number of Interactions	14 / 22
Average Interaction Score	0.946

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Stereocilium (GO:0032420)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Stereocilium membrane (GO:0060171)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Filopodium (GO:0030175)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q9Y4F9

Interaction Score

P36507

(UniProtKB/Swiss-Prot/P) Details

Dual specificity mitogen-activated protein kinase kinase 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.931	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.931	Unknown: traceable author statement	GO	PubMed
Cytosol	Peroxisomal membrane (GO:0005778)	1	Unknown: HDA	GO	PubMed
Cytosol	Microtubule (GO:0005874)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.994	Unknown: traceable author statement	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.994	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

P61586

(UniProtKB/Swiss-Prot/P) Details

Transforming protein RhoA

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cleavage furrow (GO:0032154)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.971	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.971	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	0.971	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell periphery (GO:0071944)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Extrinsic to internal side of plasma membrane (GO:0031234)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical junction complex (GO:0043296)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

Q9UBN7

(UniProtKB/Swiss-Prot/P) Details

Histone deacetylase 6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell leading edge (GO:0031252)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Inclusion body (GO:0016234)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Aggresome (GO:0016235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Histone deacetylase complex (GO:0000118)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Multivesicular body (GO:0005771)	0.3	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Microtubule associated complex (GO:0005875)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Dynein complex (GO:0030286)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule (GO:0005874)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic microtubule (GO:0005881)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Caveola (GO:0005901)	0.996	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

Q9NZM1

(UniProtKB/Swiss-Prot/P) Details

Myoferlin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.998	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.902	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear envelope (GO:0005635)	0.902	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Caveola (GO:0005901)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.998	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

P08134

(UniProtKB/Swiss-Prot/P) Details

Rho-related GTP-binding protein RhoC

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cleavage furrow (GO:0032154)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Stereocilium (GO:0032420)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.958	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.998	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

P63104

(UniProtKB/Swiss-Prot/P) Details

14-3-3 protein zeta/delta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.902	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.902	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.902	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular space (GO:0005615)	0.51	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.51	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Vesicle (GO:0031982)	0.999	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

Q9H4A3

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase WNK1

Q9Y4F9

Interaction Score

P61981

(UniProtKB/Swiss-Prot/P) Details

14-3-3 protein gamma

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.994	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.657	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.657	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q9Y4F9

Interaction Score

0.999

O75923

(UniProtKB/Swiss-Prot/P) Details

Dysferlin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle (GO:0030139)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Sarcolemma (GO:0042383)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	T-tubule (GO:0030315)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

ARHA protein

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Q9Y4F9

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q9Y4F9

P36507

Dual specificity mitogen-activated protein kinase kinase 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

P61586

Transforming protein RhoA

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

Q9UBN7

Histone deacetylase 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

Q9NZM1

Myoferlin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

P08134

Rho-related GTP-binding protein RhoC

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

P63104

14-3-3 protein zeta/delta

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

Q9H4A3

Serine/threonine-protein kinase WNK1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

P61981

14-3-3 protein gamma

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

O75923

Dysferlin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

O15534

Period circadian protein homolog 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

P49286

Melatonin receptor type 1B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9

Q9BRX7

HDAC6 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y4F9