P37173

TGF-beta receptor type-2    //   UniProt Profile 

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Species

H. sapiens

Number of Interactions

149 / 199

Average Interaction Score

0.737

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.3 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane raft (GO:0045121) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane External side of plasma membrane (GO:0009897) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Caveola (GO:0005901) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Receptor complex (GO:0043235) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Transforming growth factor beta receptor complex (GO:0070022) 1 Unknown: inferred by curator GO PubMed 

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Interactions

All Details

P37173

Interaction Score
1

P05067

(UniProtKB/Swiss-Prot/P) Details

Amyloid-beta A4 protein

P37173

Interaction Score
1

P16070

(UniProtKB/Swiss-Prot/P) Details

CD44 antigen

P37173

Interaction Score
1

P35222

(UniProtKB/Swiss-Prot/P) Details

Catenin beta-1

P37173

Interaction Score
1

P46940

(UniProtKB/Swiss-Prot/P) Details

Ras GTPase-activating-like protein IQGAP1

P37173

Interaction Score
1

Q13153

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase PAK 1

P37173

Interaction Score
1

P36897

(UniProtKB/Swiss-Prot/P) Details

TGF-beta receptor type-1

P37173

Interaction Score
1

P60953

(UniProtKB/Swiss-Prot/P) Details

Cell division control protein 42 homolog

P37173

Interaction Score
1

Q16625

(UniProtKB/Swiss-Prot/P) Details

Occludin

P37173

Interaction Score
1

P16234

(UniProtKB/Swiss-Prot/P) Details

Platelet-derived growth factor receptor alpha

P37173

Interaction Score
1

P36896

(UniProtKB/Swiss-Prot/P) Details

Activin receptor type-1B

P37173

Interaction Score
1

Q03167

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta receptor type 3

P37173

Interaction Score
1

Q96S97

(UniProtKB/Swiss-Prot/P) Details

Myeloid-associated differentiation marker

P37173

Interaction Score
1

P04626

(UniProtKB/Swiss-Prot/P) Details

Receptor tyrosine-protein kinase erbB-2

P37173

Interaction Score
1

Q96T49

(UniProtKB/Swiss-Prot/P) Details

Protein phosphatase 1 regulatory inhibitor subunit 16B

P37173

Interaction Score
1

P37023

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase receptor R3

P37173

Interaction Score
1

P10909

(UniProtKB/Swiss-Prot/P) Details

Clusterin

P37173

Interaction Score
1

P17813

(UniProtKB/Swiss-Prot/P) Details

Endoglin

P37173

Interaction Score
1

O14786

(UniProtKB/Swiss-Prot/P) Details

Neuropilin-1

P37173

Interaction Score
1

Q16513

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase N2

P37173

Interaction Score
1

Q13332

(UniProtKB/Swiss-Prot/P) Details

Receptor-type tyrosine-protein phosphatase S

P37173

Interaction Score
1

Q9HD26

(UniProtKB/Swiss-Prot/P) Details

Golgi-associated PDZ and coiled-coil motif-containing protein

P37173

Interaction Score
1

Q04771

(UniProtKB/Swiss-Prot/P) Details

Activin receptor type-1

P37173

Interaction Score
1

P36894

(UniProtKB/Swiss-Prot/P) Details

Bone morphogenetic protein receptor type-1A

P37173

Interaction Score
1

P27037

(UniProtKB/Swiss-Prot/P) Details

Activin receptor type-2A

P37173

Interaction Score
1

P11362

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor receptor 1

P37173

Interaction Score
1

O60462

(UniProtKB/Swiss-Prot/P) Details

Neuropilin-2

P37173

Interaction Score
1

Q8IX30

(UniProtKB/Swiss-Prot/P) Details

Signal peptide, CUB and EGF-like domain-containing protein 3

P37173

Interaction Score
1

P22681

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase CBL

P37173

Interaction Score
1

Q13705

(UniProtKB/Swiss-Prot/P) Details

Activin receptor type-2B

P37173

Interaction Score
0.999

P01137

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-1

P37173

Interaction Score
0.999

Q7Z418

(UniProtKB/Swiss-Prot/P) Details

Potassium channel subfamily K member 18

P37173

Interaction Score
0.999

P07900

(UniProtKB/Swiss-Prot/P) Details

Heat shock protein HSP 90-alpha

P37173

Interaction Score
0.999

Q9NPF0

(UniProtKB/Swiss-Prot/P) Details

CD320 antigen

P37173

Interaction Score
0.999

P09486

(UniProtKB/Swiss-Prot/P) Details

SPARC

P37173

Interaction Score
0.999

P98082

(UniProtKB/Swiss-Prot/P) Details

Disabled homolog 2

P37173

Interaction Score
0.998

Q9BT67

(UniProtKB/Swiss-Prot/P) Details

NEDD4 family-interacting protein 1

P37173

Interaction Score
0.998

Q86X29

(UniProtKB/Swiss-Prot/P) Details

Lipolysis-stimulated lipoprotein receptor

P37173

Interaction Score
0.996

P55082

(UniProtKB/Swiss-Prot/P) Details

Microfibril-associated glycoprotein 3

P37173

Interaction Score
0.994

Q9Y4K3

(UniProtKB/Swiss-Prot/P) Details

TNF receptor-associated factor 6

P37173

Interaction Score
0.994

O15105

(UniProtKB/Swiss-Prot/P) Details

Mothers against decapentaplegic homolog 7

P37173

Interaction Score
0.994

P10586

(UniProtKB/Swiss-Prot/P) Details

Receptor-type tyrosine-protein phosphatase F

P37173

Interaction Score
0.993

Q02750

(UniProtKB/Swiss-Prot/P) Details

Dual specificity mitogen-activated protein kinase kinase 1

P37173

Interaction Score
0.992

P42338

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

P37173

Interaction Score
0.992

Q96B97

(UniProtKB/Swiss-Prot/P) Details

SH3 domain-containing kinase-binding protein 1

P37173

Interaction Score
0.991

P29353

(UniProtKB/Swiss-Prot/P) Details

SHC-transforming protein 1

P37173

Interaction Score
0.99

P61812

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-2

P37173

Interaction Score
0.99

P10600

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-3

P37173

Interaction Score
0.989

P20340

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-6A

P37173

Interaction Score
0.985

Q14155

(UniProtKB/Swiss-Prot/P) Details

Rho guanine nucleotide exchange factor 7

P37173

Interaction Score
0.984

Q9NRW1

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-6B

P37173

Interaction Score
0.981

Q9H992

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase MARCH7

P37173

Interaction Score
0.98

Q969Z4

(UniProtKB/Swiss-Prot/P) Details

Tumor necrosis factor receptor superfamily member 19L

P37173

Interaction Score
0.98

P02750

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich alpha-2-glycoprotein

P37173

Interaction Score
0.978

Q5T7S2

(UniProtKB/TrEmbl/P) Details

Receptor protein serine/threonine kinase

P37173

Interaction Score
0.975

Q9NZ56

(UniProtKB/Swiss-Prot/P) Details

Formin-2

P37173

Interaction Score
0.975

P63010

(UniProtKB/Swiss-Prot/P) Details

AP-2 complex subunit beta

P37173

Interaction Score
0.975

Q9H223

(UniProtKB/Swiss-Prot/P) Details

EH domain-containing protein 4

P37173

Interaction Score
0.968

Q7Z4F1

(UniProtKB/Swiss-Prot/P) Details

Low-density lipoprotein receptor-related protein 10

P37173

Interaction Score
0.964

Q9HCE7

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase SMURF1

P37173

Interaction Score
0.955

Q12841

(UniProtKB/Swiss-Prot/P) Details

Follistatin-related protein 1

P37173

Interaction Score
0.954

A0A0A0MR60

(UniProtKB/TrEmbl/P) Details

Receptor-type tyrosine-protein phosphatase S

P37173

Interaction Score
0.95

Q8WUH2

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor-beta receptor-associated protein 1

P37173

Interaction Score
0.947

P23458

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein kinase JAK1

P37173

Interaction Score
0.945

B4DY26

(UniProtKB/TrEmbl/P) Details

Receptor protein serine/threonine kinase

P37173

Interaction Score
0.945

J3QLU9

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P37173

Interaction Score
0.94

Q14689

(UniProtKB/Swiss-Prot/P) Details

Disco-interacting protein 2 homolog A

P37173

Interaction Score
0.924

Q9UNH7

(UniProtKB/Swiss-Prot/P) Details

Sorting nexin-6

P37173

Interaction Score
0.915

Q9BUZ4

(UniProtKB/Swiss-Prot/P) Details

TNF receptor-associated factor 4

P37173

Interaction Score
0.914

P27986

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3-kinase regulatory subunit alpha

P37173

Interaction Score
0.902

P84022

(UniProtKB/Swiss-Prot/P) Details

Mothers against decapentaplegic homolog 3

P37173

Interaction Score
0.902

O43294

(UniProtKB/Swiss-Prot/P) Details

Transforming growth factor beta-1-induced transcript 1 protein

P37173

Interaction Score
0.892

Q7Z3T9

(UniProtKB/TrEmbl/P) Details

Neuropilin

P37173

Interaction Score
0.891

Q7Z736

(UniProtKB/Swiss-Prot/P) Details

Pleckstrin homology domain-containing family H member 3

P37173

Interaction Score
0.876

Q9HAU4

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase SMURF2

P37173

Interaction Score
0.853

O14746

(UniProtKB/Swiss-Prot/P) Details

Telomerase reverse transcriptase

P37173

Interaction Score
0.851

Q5JR98

(UniProtKB/Swiss-Prot/P) Details

Tctex1 domain-containing protein 4

P37173

Interaction Score
0.85

O95248

(UniProtKB/Swiss-Prot/P) Details

Myotubularin-related protein 5

P37173

Interaction Score
0.848

F5H6W4

(UniProtKB/TrEmbl/P) Details

E3 ubiquitin-protein ligase MARCH7

P37173

Interaction Score
0.848

F5H1T4

(UniProtKB/TrEmbl/P) Details

Receptor tyrosine-protein kinase erbB-2

P37173

Interaction Score
0.848

Q8NHS7

(UniProtKB/TrEmbl/P) Details

PTPRS protein

P37173

Interaction Score
0.824

P14635

(UniProtKB/Swiss-Prot/P) Details

G2/mitotic-specific cyclin-B1

P37173

Interaction Score
0.824

O95067

(UniProtKB/Swiss-Prot/P) Details

G2/mitotic-specific cyclin-B2

P37173

Interaction Score
0.823

O95476

(UniProtKB/Swiss-Prot/P) Details

CTD nuclear envelope phosphatase 1

P37173

Interaction Score
0.823

O43318

(UniProtKB/Swiss-Prot/P) Details

Mitogen-activated protein kinase kinase kinase 7

P37173

Interaction Score
0.819

Q12931

(UniProtKB/Swiss-Prot/P) Details

Heat shock protein 75 kDa, mitochondrial

P37173

Interaction Score
0.8

Q96CG0

(UniProtKB/TrEmbl/P) Details

ENG protein

P37173

Interaction Score
0.8

B4DGU4

(UniProtKB/TrEmbl/P) Details

Catenin beta-1

P37173

Interaction Score
0.8

Q5JPT6

(UniProtKB/TrEmbl/P) Details

GIG10

P37173

Interaction Score
0.8

Q9Y2H8

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 510

P37173

Interaction Score
0.79

P29597

(UniProtKB/Swiss-Prot/P) Details

Non-receptor tyrosine-protein kinase TYK2

P37173

Interaction Score
0.789

Q15052

(UniProtKB/Swiss-Prot/P) Details

Rho guanine nucleotide exchange factor 6

P37173

Interaction Score
0.772

A0A0A0MRG2

(UniProtKB/TrEmbl/P) Details

Amyloid-beta A4 protein

P37173

Interaction Score
0.771

Q93074

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 12

P37173

Interaction Score
0.763

Q8TAX0

(UniProtKB/Swiss-Prot/P) Details

Protein odd-skipped-related 1

P37173

Interaction Score
0.763

Q6AWA9

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686A03134

P37173

Interaction Score
0.748

A8MVW0

(UniProtKB/Swiss-Prot/P) Details

Protein FAM171A2

P37173

Interaction Score
0.748

O95405

(UniProtKB/Swiss-Prot/P) Details

Zinc finger FYVE domain-containing protein 9

P37173

Interaction Score
0.748

Q99741

(UniProtKB/Swiss-Prot/P) Details

Cell division control protein 6 homolog

P37173

Interaction Score
0.746

P29590

(UniProtKB/Swiss-Prot/P) Details

Protein PML

P37173

Interaction Score
0.737

Q5JSH3

(UniProtKB/Swiss-Prot/P) Details

WD repeat-containing protein 44

P37173

Interaction Score
0.7

Q5T9B9

(UniProtKB/TrEmbl/P) Details

Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_b

P37173

Interaction Score
0.7

Q96NX2

(UniProtKB/TrEmbl/P) Details

KIAA0184 protein

P37173

Interaction Score
0.64

B4DXN7

(UniProtKB/TrEmbl/P) Details

Receptor protein serine/threonine kinase

P37173

Interaction Score
0.64

A0A140VJE8

(UniProtKB/TrEmbl/P) Details

AP complex subunit beta

P37173

Interaction Score
0.64

D3DPA4

(UniProtKB/TrEmbl/P) Details

Serine/threonine-protein kinase receptor

P37173

Interaction Score
0.64

A8K9V7

(UniProtKB/TrEmbl/P) Details

Neuropilin

P37173

Interaction Score
0.64

Q68DN3

(UniProtKB/TrEmbl/P) Details

Neuropilin

P37173

Interaction Score
0.64

Q6X907

(UniProtKB/TrEmbl/P) Details

Neuropilin

P37173

Interaction Score
0.64

A0A024R7E4

(UniProtKB/TrEmbl/P) Details

Tyrosine-protein kinase

P37173

Interaction Score
0.64

X5DNK3

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P37173

Interaction Score
0.64

A0A0S2Z3Q6

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

P37173

Interaction Score
0.56

Q59EG9

(UniProtKB/TrEmbl/P) Details

Transforming growth factor, beta 2 variant

P37173

Interaction Score
0.491

P35243

(UniProtKB/Swiss-Prot/P) Details

Recoverin

P37173

Interaction Score
0.3

Q13485

(UniProtKB/Swiss-Prot/P) Details

Mothers against decapentaplegic homolog 4

P37173

Interaction Score
0.3

Q9Y3F4

(UniProtKB/Swiss-Prot/P) Details

Serine-threonine kinase receptor-associated protein

P37173

Interaction Score
0.3

Q9NS23

(UniProtKB/Swiss-Prot/P) Details

Ras association domain-containing protein 1

P37173

Interaction Score
0.3

Q8IWF6

(UniProtKB/Swiss-Prot/P) Details

Protein DENND6A

P37173

Interaction Score
0.3

O95747

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase OSR1

P37173

Interaction Score
0.3

Q92569

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3-kinase regulatory subunit gamma

P37173

Interaction Score
0.298

Q00597

(UniProtKB/Swiss-Prot/P) Details

Fanconi anemia group C protein

P37173

Interaction Score
0.298

Q86TG7

(UniProtKB/Swiss-Prot/P) Details

Retrotransposon-derived protein PEG10

P37173

Interaction Score
0.297

Q6P5Z2

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase N3

P37173

Interaction Score
0.297

Q13347

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic translation initiation factor 3 subunit I

P37173

Interaction Score
0.296

Q15714

(UniProtKB/Swiss-Prot/P) Details

TSC22 domain family protein 1

P37173

Interaction Score
0.296

Q14258

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin/ISG15 ligase TRIM25

P37173

Interaction Score
0.294

Q96BD6

(UniProtKB/Swiss-Prot/P) Details

SPRY domain-containing SOCS box protein 1

P37173

Interaction Score
0.294

P62714

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

P37173

Interaction Score
0.287

Q9UER7

(UniProtKB/Swiss-Prot/P) Details

Death domain-associated protein 6

P37173

Interaction Score
0.287

Q14568

(UniProtKB/Swiss-Prot/P) Details

Heat shock protein HSP 90-alpha A2

P37173

Interaction Score
0.281

O00459

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3-kinase regulatory subunit beta

P37173

Interaction Score
0.273

Q6P669

(UniProtKB/TrEmbl/P) Details

JAK1 protein

P37173

Interaction Score
0.24

Q96DE7

(UniProtKB/TrEmbl/P) Details

SMURF2 protein

P37173

Interaction Score
0.24

A0A0A0MRI2

(UniProtKB/TrEmbl/P) Details

Sorting nexin

P37173

Interaction Score
0.24

E9PG40

(UniProtKB/TrEmbl/P) Details

Amyloid-beta A4 protein

P37173

Interaction Score
0.24

B4DSP0

(UniProtKB/TrEmbl/P) Details

HCG1642748, isoform CRA_b

P37173

Interaction Score
0.24

Q53F85

(UniProtKB/TrEmbl/P) Details

Death-associated protein 6 variant

P37173

Interaction Score
0.21

Q96EL6

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

P37173

Interaction Score
0.21

Q86SX1

(UniProtKB/TrEmbl/P) Details

Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens

P37173

Interaction Score
0.21

Q8N4Q3

(UniProtKB/TrEmbl/P) Details

Similar to Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

P37173

Interaction Score
0.21

Q9NWN3

(UniProtKB/Swiss-Prot/P) Details

F-box only protein 34

P37173

Interaction Score
0.21

Q68CY7

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686P05226

P37173

Interaction Score
0.21

Q7Z3W2

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686F1293

P37173

Interaction Score
0.21

Q8N381

(UniProtKB/TrEmbl/P) Details

Phosphoinositide-3-kinase, regulatory subunit 3

P37173

Interaction Score
0.21

Q53ET8

(UniProtKB/TrEmbl/P) Details

RAB6A, member RAS oncogene family isoform a variant

P37173

Interaction Score
0.21

Q9BU70

(UniProtKB/Swiss-Prot/P) Details

tRNA (adenine(37)-N6)-methyltransferase

P37173

Interaction Score
0

A0A087X0H8

(UniProtKB/TrEmbl/P) Details

TSC22 domain family protein 1

P37173

Interaction Score
0

Q59F20

(UniProtKB/TrEmbl/P) Details

Neuropilin-1 variant

P37173

Interaction Score
0

X6R3U4

(UniProtKB/TrEmbl/P) Details

Pleckstrin homology domain-containing family H member 3

P37173

Interaction Score
0

Q9HBL1

(UniProtKB/TrEmbl/P) Details

HT016

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ComPPI is published in Nucleic Acids Research Database Issue 2015