P34574

Probable clathrin heavy chain 1    //   UniProt Profile 

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Species

 C. elegans

Number of Interactions

 25 / 33

Average Interaction Score

 0.767

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cell cortex (GO:0005938) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endocytic vesicle (GO:0030139) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Clathrin-coated endocytic vesicle (GO:0045334) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Clathrin coat of trans-Golgi network vesicle (GO:0030130) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Mitotic spindle (GO:0072686) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Clathrin complex (GO:0071439) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Experimental: inferred from direct assay GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.996 Experimental: inferred from direct assay GO PubMed 
Membrane Clathrin coat of coated pit (GO:0030132) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: experimental eSLDB PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P34574

Interaction Score
1

G5ECY0

(UniProtKB/Swiss-Prot/P) Details

Disks large homolog 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Postsynaptic density (GO:0014069) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Lateral plasma membrane (GO:0016328) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Apical junction complex (GO:0043296) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Ionotropic glutamate receptor complex (GO:0008328) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Basolateral plasma membrane (GO:0016323) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Adherens junction (GO:0005912) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Postsynaptic membrane (GO:0045211) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34574

Interaction Score
1

G5EFV8

(UniProtKB/Swiss-Prot/P) Details

Vacuolar protein sorting-associated protein 52 homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Perikaryon (GO:0043204) 0.972 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.972 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway GARP complex (GO:0000938) 0.988 Predicted: inferred from physical interaction GO PubMed 
Secretory-pathway Golgi trans cisterna (GO:0000138) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi medial cisterna (GO:0005797) 0.988 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.998

Q9GT24

(UniProtKB/Swiss-Prot/P) Details

Probable serine/threonine-protein kinase zyg-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Centrosome (GO:0005813) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Centriole (GO:0005814) 0.998 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.998

Q65XX1

(UniProtKB/TrEmbl/P) Details

Vasa-and Belle-like Helicase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasmic stress granule (GO:0010494) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol P granule (GO:0043186) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.997

Q22799

(UniProtKB/Swiss-Prot/P) Details

Dynein light chain 1, cytoplasmic

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.997 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasmic dynein complex (GO:0005868) 0.997 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Myosin complex (GO:0016459) 0.997 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Microtubule (GO:0005874) 0.997 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

DIP, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.988

Q9BIF4

(UniProtKB/TrEmbl/P) Details

EHS-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Axon (GO:0030424) 0.992 Experimental: inferred from mutant phenotype GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Synapse (GO:0045202) 0.992 Experimental: inferred from mutant phenotype GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.987

O76368

(UniProtKB/Swiss-Prot/P) Details

Putative cuticle collagen 99

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Collagen (GO:0005581) 0.958 Unknown: non-traceable author statement GO PubMed 
Membrane Fully spanning plasma membrane (GO:0044214) 0.96 Experimental: inferred from direct assay GO PubMed 
Membrane Neuromuscular junction (GO:0031594) 0.96 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.982

Q17796

(UniProtKB/TrEmbl/P) Details

Hepatocyte Growth factor-Regulated TK Substrate (HRS) family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway ESCRT-0 complex (GO:0033565) 0.988 Predicted: inferred from physical interaction GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.981

Q9NHC3

(UniProtKB/Swiss-Prot/P) Details

Cell death abnormality protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
N/A Cellular component (GO:0005575) 0.3 Unknown: no biological data available GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Plasma membrane (GO:0005886) 0.79 Unknown: non-traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.969

Q8I6Y9

(UniProtKB/TrEmbl/P) Details

TRP (Transient receptor potential) channel family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Integral to membrane (GO:0016021) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, CCSB

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.96

P34402

(UniProtKB/Swiss-Prot/P) Details

Spindle assembly abnormal protein 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.96 Experimental: experimental eSLDB PubMed 
Cytosol Centriole (GO:0005814) 0.96 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.958

O01422

(UniProtKB/Swiss-Prot/P) Details

COP9 signalosome complex subunit 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Signalosome (GO:0008180) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.91

Q95ZY7

(UniProtKB/TrEmbl/P) Details

Apical Junction Molecule

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.86

G5ECW9

(UniProtKB/TrEmbl/P) Details

Receptor Mediated Endocytosis

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Coated pit (GO:0005905) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular (GO:0005622) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.7

Q95XY1

(UniProtKB/TrEmbl/P) Details

Vasa-and Belle-like Helicase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.7

P34509

(UniProtKB/Swiss-Prot/P) Details

Uncharacterized protein K06H7.1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.7

Q9N3F4

(UniProtKB/TrEmbl/P) Details

Vasa-and Belle-like Helicase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.7

Q9U2T9

(UniProtKB/TrEmbl/P) Details

ITSN (Intersectin) family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.7

Q21295

(UniProtKB/TrEmbl/P) Details

Nuclear Pore complex Protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.696

Q9U3B9

(UniProtKB/TrEmbl/P) Details

Nuclear Pore complex Protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.94 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear pore central transport channel (GO:0044613) 0.94 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0.696

P91457

(UniProtKB/TrEmbl/P) Details

Nuclear Pore complex Protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear pore (GO:0005643) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear pore central transport channel (GO:0044613) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nuclear pore nuclear basket (GO:0044615) 0.999 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0.696

Q8MXS2

(UniProtKB/TrEmbl/P) Details

U2 snRNP auxiliary factor large subunit

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0

P90978

(UniProtKB/Swiss-Prot/P) Details

Splicing factor U2AF 65 kDa subunit

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear speck (GO:0016607) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Spliceosomal complex (GO:0005681) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus U2-type prespliceosome (GO:0071004) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Commitment complex (GO:0000243) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

P34574

Interaction Score
0

Q9U3C1

(UniProtKB/TrEmbl/P) Details

Nuclear Pore complex Protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

P34574

Interaction Score
0

Q95Y97

(UniProtKB/TrEmbl/P) Details

Replication Protein A homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.973 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.973 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus DNA replication factor A complex (GO:0005662) 0.973 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

BioGRID, CCSB, IntAct, DIP

Interaction Source Publication:

PubMed , PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015