Q17796

Hepatocyte Growth factor-Regulated TK Substrate (HRS) family    //   UniProt Profile 

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Species

 C. elegans

Number of Interactions

 25 / 35

Average Interaction Score

 0.683

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway ESCRT-0 complex (GO:0033565) 0.988 Predicted: inferred from physical interaction GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

Q17796

Interaction Score
0.988

Q22601

(UniProtKB/TrEmbl/P) Details

AP-2 complex subunit alpha

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Coated pit (GO:0005905) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endocytic vesicle (GO:0030139) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Clathrin-coated endocytic vesicle (GO:0045334) 0.988 Experimental: inferred from direct assay GO PubMed 
Membrane Clathrin adaptor complex (GO:0030131) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Experimental: inferred from direct assay GO PubMed 
Membrane Synapse (GO:0045202) 0.994 Experimental: inferred from direct assay GO PubMed 
Membrane Presynaptic periactive zone (GO:0036062) 0.994 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.984

O01498

(UniProtKB/Swiss-Prot/P) Details

Signal transducing adapter molecule 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endosome (GO:0005768) 0.996 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.996 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway ESCRT-0 complex (GO:0033565) 0.996 Predicted: inferred from physical interaction GO PubMed 
Membrane Cilium (GO:0005929) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

CCSB, IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed , PubMed 

Q17796

Interaction Score
0.982

P34574

(UniProtKB/Swiss-Prot/P) Details

Probable clathrin heavy chain 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cell cortex (GO:0005938) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endocytic vesicle (GO:0030139) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Clathrin-coated endocytic vesicle (GO:0045334) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Clathrin coat of trans-Golgi network vesicle (GO:0030130) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Mitotic spindle (GO:0072686) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Clathrin complex (GO:0071439) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Experimental: inferred from direct assay GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.996 Experimental: inferred from direct assay GO PubMed 
Membrane Clathrin coat of coated pit (GO:0030132) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Membrane Apical plasma membrane (GO:0016324) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.964

O76258

(UniProtKB/TrEmbl/P) Details

Tumor Susceptibility Gene homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.94 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway ESCRT I complex (GO:0000813) 0.94 Predicted: inferred from physical interaction GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.899

Q9N4F3

(UniProtKB/TrEmbl/P) Details

AP complex subunit beta

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Clathrin adaptor complex (GO:0030131) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.894

P0CG71

(UniProtKB/Swiss-Prot/P) Details

Polyubiquitin-A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.888

Q9XWK3

(UniProtKB/TrEmbl/P) Details

Nuclear Pore complex Protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nuclear pore central transport channel (GO:0044613) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.843

Q7YZG9

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.843

Q95ZV2

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

CCSB, BioGRID

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.79

P35603

(UniProtKB/Swiss-Prot/P) Details

AP-2 complex subunit mu

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Coated pit (GO:0005905) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.992 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Synaptic vesicle (GO:0008021) 0.8 Experimental: inferred from direct assay GO PubMed 
Membrane Periciliary membrane compartment (GO:1990075) 0.994 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.994 Experimental: experimental eSLDB PubMed 
Membrane Clathrin adaptor complex (GO:0030131) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Vesicle (GO:0031982) 0.992 Experimental: experimental eSLDB PubMed 
Membrane Synapse (GO:0045202) 0.994 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.781

P90961

(UniProtKB/TrEmbl/P) Details

Clathrin light chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Clathrin vesicle coat (GO:0030125) 0.79 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Clathrin coat of trans-Golgi network vesicle (GO:0030130) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Membrane Periciliary membrane compartment (GO:1990075) 0.86 Experimental: inferred from direct assay GO PubMed 
Membrane Clathrin coat of coated pit (GO:0030132) 0.86 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.692

Q7YZG8

(UniProtKB/TrEmbl/P) Details

AP complex subunit beta

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.687

Q9N359

(UniProtKB/Swiss-Prot/P) Details

COP9 signalosome complex subunit 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.982 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.982 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Signalosome (GO:0008180) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.641

Q19371

(UniProtKB/TrEmbl/P) Details

Yeast SEC homolog

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway COPII vesicle coat (GO:0030127) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.637

O62333

(UniProtKB/TrEmbl/P) Details

IMportin Beta family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.637

O62332

(UniProtKB/TrEmbl/P) Details

IMportin Beta family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.637

Q65XX1

(UniProtKB/TrEmbl/P) Details

Vasa-and Belle-like Helicase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasmic stress granule (GO:0010494) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol P granule (GO:0043186) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed 

Q17796

Interaction Score
0.56

Q10953

(UniProtKB/Swiss-Prot/P) Details

Armadillo repeat-containing protein wrm-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.988 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cell cortex (GO:0005938) 0.988 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.56

G5EDS1

(UniProtKB/TrEmbl/P) Details

Variable abnormal-3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.49

P54936

(UniProtKB/Swiss-Prot/P) Details

Protein lin-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.86 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.49

Q9U2T9

(UniProtKB/TrEmbl/P) Details

ITSN (Intersectin) family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.49

Q9N3F4

(UniProtKB/TrEmbl/P) Details

Vasa-and Belle-like Helicase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.49

Q95XY1

(UniProtKB/TrEmbl/P) Details

Vasa-and Belle-like Helicase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0.21

A0A131MBF9

(UniProtKB/TrEmbl/P) Details

IMportin Beta family

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

Q17796

Interaction Score
0

Q9BIF4

(UniProtKB/TrEmbl/P) Details

EHS-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Axon (GO:0030424) 0.992 Experimental: inferred from mutant phenotype GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Synapse (GO:0045202) 0.992 Experimental: inferred from mutant phenotype GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015