A8MW95

Beclin-2    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 6 / 6

Average Interaction Score

 0.972

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Pre-autophagosomal structure (GO:0000407) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Phosphatidylinositol 3-kinase complex I (GO:0034271) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Phosphatidylinositol 3-kinase complex II (GO:0034272) 0.973 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

A8MW95

Interaction Score
0.991

Q9P2Y5

(UniProtKB/Swiss-Prot/P) Details

UV radiation resistance-associated gene protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Midbody (GO:0030496) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.994 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Late endosome (GO:0005770) 0.994 Experimental: inferred from direct assay GO PubMed 
Cytosol HOPS complex (GO:0030897) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Lysosome (GO:0005764) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Phagocytic vesicle (GO:0045335) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Centrosome (GO:0005813) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Chromosome, centromeric region (GO:0000775) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

A8MW95

Interaction Score
0.989

Q8NEB9

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3-kinase catalytic subunit type 3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Midbody (GO:0030496) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Pre-autophagosomal structure (GO:0000407) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Phosphatidylinositol 3-kinase complex I (GO:0034271) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Phosphatidylinositol 3-kinase complex II (GO:0034272) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Phosphatidylinositol 3-kinase complex, class III (GO:0035032) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Late endosome (GO:0005770) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Peroxisome (GO:0005777) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Phagocytic vesicle membrane (GO:0030670) 0.86 Unknown: traceable author statement GO PubMed 
Cytosol Axoneme (GO:0005930) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

A8MW95

Interaction Score
0.988

Q9C0C7

(UniProtKB/Swiss-Prot/P) Details

Activating molecule in BECN1-regulated autophagy protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Unknown: traceable author statement GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.972 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 0.972 Unknown: non-traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Autophagic vacuole (GO:0005776) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Phagocytic vesicle (GO:0045335) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Axoneme (GO:0005930) 1 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

A8MW95

Interaction Score
0.982

Q6ZNE5

(UniProtKB/Swiss-Prot/P) Details

Beclin 1-associated autophagy-related key regulator

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Pre-autophagosomal structure membrane (GO:0034045) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Phosphatidylinositol 3-kinase complex, class III (GO:0035032) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: pTarget method LOCATE PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.51 Unknown: traceable author statement GO PubMed 
Cytosol Autophagic vacuole (GO:0005776) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Autophagic vacuole membrane (GO:0000421) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Phagocytic vesicle (GO:0045335) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Axoneme (GO:0005930) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

A8MW95

Interaction Score
0.948

P10415

(UniProtKB/Swiss-Prot/P) Details

Apoptosis regulator Bcl-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Myelin sheath (GO:0043209) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.86 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental Organelle PubMed 
Mitochondrion Pore complex (GO:0046930) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from mutant phenotype GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.972 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.972 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.972 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

A8MW95

Interaction Score
0.934

Q5JY77

(UniProtKB/Swiss-Prot/P) Details

G-protein coupled receptor-associated sorting protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015