H0YNS4

TM2 domain-containing protein 3 // UniProt Profile

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Species	H. sapiens
Number of Interactions	41 / 62
Average Interaction Score	0.495

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

H0YNS4

Interaction Score

0.954

P24468

(UniProtKB/Swiss-Prot/P) Details

COUP transcription factor 2

H0YNS4

Interaction Score

0.95

O00148

(UniProtKB/Swiss-Prot/P) Details

ATP-dependent RNA helicase DDX39A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.94	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Spliceosomal complex (GO:0005681)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

0.933

Q9BSJ5

(UniProtKB/Swiss-Prot/P) Details

Uncharacterized protein C17orf80

H0YNS4

Interaction Score

0.928

Q6ZW49

(UniProtKB/Swiss-Prot/P) Details

PAX-interacting protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Histone methyltransferase complex (GO:0035097)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	MLL3/4 complex (GO:0044666)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

0.923

I3L072

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein C17orf80

H0YNS4

Interaction Score

0.888

Q96FV3

(UniProtKB/Swiss-Prot/P) Details

Tetraspanin-17

H0YNS4

Interaction Score

0.88

Q02297

(UniProtKB/Swiss-Prot/P) Details

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Cell body (GO:0044297)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axolemma (GO:0030673)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.987	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Experimental: experimental	MatrixDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.976	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

0.87

Q6P9F7

(UniProtKB/Swiss-Prot/P) Details

Volume-regulated anion channel subunit LRRC8B

H0YNS4

Interaction Score

0.87

Q9BX73

(UniProtKB/Swiss-Prot/P) Details

TM2 domain-containing protein 2

H0YNS4

Interaction Score

0.848

Q9UJM3

(UniProtKB/Swiss-Prot/P) Details

ERBB receptor feedback inhibitor 1

H0YNS4

Interaction Score

0.81

Q7Z4G1

(UniProtKB/Swiss-Prot/P) Details

COMM domain-containing protein 6

H0YNS4

Interaction Score

0.799

P56539

(UniProtKB/Swiss-Prot/P) Details

Caveolin-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Z disc (GO:0030018)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Membrane raft (GO:0045121)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dystrophin-associated glycoprotein complex (GO:0016010)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Sarcolemma (GO:0042383)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	T-tubule (GO:0030315)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Caveola (GO:0005901)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Vesicle (GO:0031982)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Intercalated disc (GO:0014704)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

0.778

Q12841

(UniProtKB/Swiss-Prot/P) Details

Follistatin-related protein 1

H0YNS4

Interaction Score

0.778

Q9Y6A9

(UniProtKB/Swiss-Prot/P) Details

Signal peptidase complex subunit 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.972	Experimental: experimental	Organelle	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Signal peptidase complex (GO:0005787)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Integral to endoplasmic reticulum membrane (GO:0030176)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Integral to endoplasmic reticulum membrane (GO:0030176)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.94	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.94	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Organelle membrane (GO:0031090)	0.972	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

0.728

Q7RTW5

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-gamma

H0YNS4

Interaction Score

0.726

Q15005

(UniProtKB/Swiss-Prot/P) Details

Signal peptidase complex subunit 2

H0YNS4

Interaction Score

0.64

X6R2S6

(UniProtKB/TrEmbl/P) Details

Signal peptidase complex subunit 1 homolog

H0YNS4

Interaction Score

0.64

F6RJN6

(UniProtKB/TrEmbl/P) Details

Pro-neuregulin-1, membrane-bound isoform

H0YNS4

Interaction Score

0.64

J3KNG2

(UniProtKB/TrEmbl/P) Details

Tetraspanin

H0YNS4

Interaction Score

0.64

Q15818

(UniProtKB/Swiss-Prot/P) Details

Neuronal pentraxin-1

H0YNS4

Interaction Score

0.64

Q86UD1

(UniProtKB/Swiss-Prot/P) Details

Out at first protein homolog

H0YNS4

Interaction Score

0.632

Q8NFQ8

(UniProtKB/Swiss-Prot/P) Details

Torsin-1A-interacting protein 2

H0YNS4

Interaction Score

0.56

Q9UDX5

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial fission process protein 1

H0YNS4

Interaction Score

0.56

Q7RTW3

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-beta2

H0YNS4

Interaction Score

0.56

Q6PK61

(UniProtKB/TrEmbl/P) Details

Neuregulin 1

H0YNS4

Interaction Score

0.408

Q8TD20

(UniProtKB/Swiss-Prot/P) Details

Solute carrier family 2, facilitated glucose transporter member 12

H0YNS4

Interaction Score

0.24

P07766

(UniProtKB/Swiss-Prot/P) Details

T-cell surface glycoprotein CD3 epsilon chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	T cell receptor complex (GO:0042101)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Alpha-beta T cell receptor complex (GO:0042105)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cell body (GO:0044297)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Immunological synapse (GO:0001772)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

0.24

Q15758

(UniProtKB/Swiss-Prot/P) Details

Neutral amino acid transporter

H0YNS4

Interaction Score

0.24

O94985

(UniProtKB/Swiss-Prot/P) Details

Calsyntenin-1

H0YNS4

Interaction Score

Q5BJH2

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 128

H0YNS4

Interaction Score

Q9HBV2

(UniProtKB/Swiss-Prot/P) Details

Sperm acrosome membrane-associated protein 1

H0YNS4

Interaction Score

O95881

(UniProtKB/Swiss-Prot/P) Details

Thioredoxin domain-containing protein 12

H0YNS4

Interaction Score

Q5STB3

(UniProtKB/TrEmbl/P) Details

Tumor necrosis factor-alpha

H0YNS4

Interaction Score

P01375

(UniProtKB/Swiss-Prot/P) Details

Tumor necrosis factor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.94	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Phagocytic cup (GO:0001891)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

H0YNS4

Interaction Score

Q6UX41

(UniProtKB/Swiss-Prot/P) Details

Butyrophilin-like protein 8

H0YNS4

Interaction Score

A0A024R2D8

(UniProtKB/TrEmbl/P) Details

Caveolin

H0YNS4

Interaction Score

A0A024R7Q6

(UniProtKB/TrEmbl/P) Details

Tetraspanin

H0YNS4

Interaction Score

Q01113

(UniProtKB/Swiss-Prot/P) Details

Interleukin-9 receptor

H0YNS4

Interaction Score

Q59ES3

(UniProtKB/TrEmbl/P) Details

Amino acid transporter

H0YNS4

Interaction Score

Q9H496

(UniProtKB/Swiss-Prot/P) Details

Torsin-1A-interacting protein 2, isoform IFRG15

H0YNS4

Interaction Score

Q14627

(UniProtKB/Swiss-Prot/P) Details

Interleukin-13 receptor subunit alpha-2

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H0YNS4

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

H0YNS4

P24468

COUP transcription factor 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

O00148

ATP-dependent RNA helicase DDX39A

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q9BSJ5

Uncharacterized protein C17orf80

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q6ZW49

PAX-interacting protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

I3L072

Uncharacterized protein C17orf80

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q96FV3

Tetraspanin-17

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q02297

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q6P9F7

Volume-regulated anion channel subunit LRRC8B

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q9BX73

TM2 domain-containing protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q9UJM3

ERBB receptor feedback inhibitor 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

Q7Z4G1

COMM domain-containing protein 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4

P56539

Caveolin-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

H0YNS4