O15258

Protein RER1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	50 / 60
Average Interaction Score	0.867

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.8	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Integral to Golgi membrane (GO:0030173)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Integral to Golgi membrane (GO:0030173)	1	Experimental: experimental	Organelle	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

O15258

Interaction Score

P51572

(UniProtKB/Swiss-Prot/P) Details

B-cell receptor-associated protein 31

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Lipid particle (GO:0005811)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear endoplasmic reticulum (GO:0097038)	0.972	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Sec61 translocon complex (GO:0005784)	1	Predicted: inferred from physical interaction	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi cisterna membrane (GO:0032580)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Clathrin-coated vesicle (GO:0030136)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.992	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.992	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

Q86TM6

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase synoviolin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Smooth endoplasmic reticulum (GO:0005790)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Hrd1p ubiquitin ligase complex (GO:0000836)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Hrd1p ubiquitin ligase ERAD-L complex (GO:0000839)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Integral to endoplasmic reticulum membrane (GO:0030176)	1	Unknown: non-traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum quality control compartment (GO:0044322)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.992	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

P00533

(UniProtKB/Swiss-Prot/P) Details

Epidermal growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.972	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Clathrin coated vesicle membrane (GO:0030665)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	AP-2 adaptor complex (GO:0030122)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Shc-EGFR complex (GO:0070435)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

Q86Y82

(UniProtKB/Swiss-Prot/P) Details

Syntaxin-12

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Pre-autophagosomal structure (GO:0000407)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	BLOC-1 complex (GO:0031083)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	0.996	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane raft (GO:0045121)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	SNARE complex (GO:0031201)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: inferred from mutant phenotype	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

P62820

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-1A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Unknown: HDA	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

P20036

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DP alpha 1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.994	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.942	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.992	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.942	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.942	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Unknown: traceable author statement	GO	PubMed
Membrane	MHC class II protein complex (GO:0042613)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.994	Unknown: non-traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.999

Q9Y282

(UniProtKB/Swiss-Prot/P) Details

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.7	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.986	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.986	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.853	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.853	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.853	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.999

Q6P5W5

(UniProtKB/Swiss-Prot/P) Details

Zinc transporter ZIP4

O15258

Interaction Score

0.998

Q96GX1

(UniProtKB/Swiss-Prot/P) Details

Tectonic-2

O15258

Interaction Score

0.995

P25705

(UniProtKB/Swiss-Prot/P) Details

ATP synthase subunit alpha, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Proton-transporting ATP synthase complex (GO:0045259)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Proton-transporting ATP synthase complex (GO:0045259)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Proton-transporting ATP synthase complex, catalytic core F(1) (GO:0045261)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Unknown: non-traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	1	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial proton-transporting ATP synthase complex (GO:0005753)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Signalosome (GO:0008180)	0.96	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Unknown: HDA	GO	PubMed
Membrane	Proton-transporting two-sector ATPase complex (GO:0016469)	0.996	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.995

Q6NUS6

(UniProtKB/Swiss-Prot/P) Details

Tectonic-3

O15258

Interaction Score

0.995

P45880

(UniProtKB/Swiss-Prot/P) Details

Voltage-dependent anion-selective channel protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Myelin sheath (GO:0043209)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial nucleoid (GO:0042645)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Pore complex (GO:0046930)	1	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Secretory-pathway	Acrosomal vesicle (GO:0001669)	0.958	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.993

P48047

(UniProtKB/Swiss-Prot/P) Details

ATP synthase subunit O, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Proton-transporting ATP synthase complex (GO:0045259)	0.96	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial proton-transporting ATP synthase complex (GO:0005753)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Proton-transporting two-sector ATPase complex (GO:0016469)	0.96	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.96	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.992

P16444

(UniProtKB/Swiss-Prot/P) Details

Dipeptidase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Apical part of cell (GO:0045177)	0.86	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Microvillus membrane (GO:0031528)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Anchored to membrane (GO:0031225)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.992

O00322

(UniProtKB/Swiss-Prot/P) Details

Uroplakin-1a

O15258

Interaction Score

0.99

Q9H5K3

(UniProtKB/Swiss-Prot/P) Details

Protein O-mannose kinase

O15258

Interaction Score

0.989

A2TJK5

(UniProtKB/TrEmbl/P) Details

ERGIC and golgi 3, isoform CRA_a

O15258

Interaction Score

0.987

Q86X19

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 17

O15258

Interaction Score

0.98

P11441

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-like protein 4A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	BAT3 complex (GO:0071818)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.979

Q8TD20

(UniProtKB/Swiss-Prot/P) Details

Solute carrier family 2, facilitated glucose transporter member 12

O15258

Interaction Score

0.977

Q9P0N5

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 216

O15258

Interaction Score

0.964

Q9UGM1

(UniProtKB/Swiss-Prot/P) Details

Neuronal acetylcholine receptor subunit alpha-9

O15258

Interaction Score

0.964

Q01453

(UniProtKB/Swiss-Prot/P) Details

Peripheral myelin protein 22

O15258

Interaction Score

0.961

Q99963

(UniProtKB/Swiss-Prot/P) Details

Endophilin-A3

O15258

Interaction Score

0.961

P62079

(UniProtKB/Swiss-Prot/P) Details

Tetraspanin-5

O15258

Interaction Score

0.955

Q16891

(UniProtKB/Swiss-Prot/P) Details

MICOS complex subunit MIC60

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	MICOS complex (GO:0061617)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.51	Unknown: HDA	GO	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.96	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

HPRD, IntAct, BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.951

Q9NX22

(UniProtKB/TrEmbl/P) Details

cDNA FLJ20482 fis, clone KAT07592

O15258

Interaction Score

0.947

O95714

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase HERC2

O15258

Interaction Score

0.927

P54257

(UniProtKB/Swiss-Prot/P) Details

Huntingtin-associated protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Inclusion body (GO:0016234)	0.995	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.995	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.995	Experimental: experimental	Organelle	PubMed
Cytosol	Centrosome (GO:0005813)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Centriole (GO:0005814)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.995	Unknown: traceable author statement	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, HPRD, BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.909

Q17RD7

(UniProtKB/Swiss-Prot/P) Details

Synaptotagmin-16

O15258

Interaction Score

0.9

E9PFD7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

O15258

Interaction Score

0.9

Q504U8

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

O15258

Interaction Score

0.9

Q6FH25

(UniProtKB/TrEmbl/P) Details

Peripheral myelin protein 22

O15258

Interaction Score

0.87

O75964

(UniProtKB/Swiss-Prot/P) Details

ATP synthase subunit g, mitochondrial

O15258

Interaction Score

0.8

A1L190

(UniProtKB/Swiss-Prot/P) Details

Synaptonemal complex central element protein 3

O15258

Interaction Score

0.794

Q8IWL3

(UniProtKB/Swiss-Prot/P) Details

Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

O15258

Interaction Score

0.79

Q14258

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin/ISG15 ligase TRIM25

O15258

Interaction Score

0.778

Q9C0B0

(UniProtKB/Swiss-Prot/P) Details

RING finger protein unkempt homolog

O15258

Interaction Score

0.768

P57086

(UniProtKB/Swiss-Prot/P) Details

SCAN domain-containing protein 1

O15258

Interaction Score

0.752

Q99496

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase RING2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.94	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	MLL1 complex (GO:0071339)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PcG protein complex (GO:0031519)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PRC1 complex (GO:0035102)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Euchromatin (GO:0000791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Sex chromatin (GO:0001739)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.737

O75947

(UniProtKB/Swiss-Prot/P) Details

ATP synthase subunit d, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial proton-transporting ATP synthase complex (GO:0005753)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial proton-transporting ATP synthase, stator stalk (GO:0000274)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O15258

Interaction Score

0.64

A8MU75

(UniProtKB/TrEmbl/P) Details

Peripheral myelin protein 22

O15258

Interaction Score

0.64

P56385

(UniProtKB/Swiss-Prot/P) Details

ATP synthase subunit e, mitochondrial

O15258

Interaction Score

0.64

B7Z2I3

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

O15258

Interaction Score

0.64

A0A140VJI3

(UniProtKB/TrEmbl/P) Details

Dipeptidase

O15258

Interaction Score

0.64

E7BSV0

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

O15258

Interaction Score

0.64

F2YGG7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

O15258

Interaction Score

0.56

Q9BVR0

(UniProtKB/Swiss-Prot/P) Details

Putative HERC2-like protein 3

O15258

Interaction Score

0.56

O95758

(UniProtKB/Swiss-Prot/P) Details

Polypyrimidine tract-binding protein 3

O15258

Interaction Score

A0PJH2

(UniProtKB/TrEmbl/P) Details

ATP5H protein

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O15258

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

O15258

P51572

B-cell receptor-associated protein 31

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

Q86TM6

E3 ubiquitin-protein ligase synoviolin

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

P00533

Epidermal growth factor receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

Q86Y82

Syntaxin-12

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

P62820

Ras-related protein Rab-1A

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

P20036

HLA class II histocompatibility antigen, DP alpha 1 chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

Q9Y282

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

Q6P5W5

Zinc transporter ZIP4

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

Q96GX1

Tectonic-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

P25705

ATP synthase subunit alpha, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

Q6NUS6

Tectonic-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258

P45880

Voltage-dependent anion-selective channel protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

O15258