O43196

MutS protein homolog 5    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 11 / 13

Average Interaction Score

 0.958

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Mismatch repair complex (GO:0032300) 0.992 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Synaptonemal complex (GO:0000795) 0.992 Predicted: inferred from biological aspect of ancestor GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

O43196

Interaction Score
1

O14980

(UniProtKB/Swiss-Prot/P) Details

Exportin-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear envelope (GO:0005635) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Cajal body (GO:0015030) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Kinetochore (GO:0000776) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Extracellular Host cell (GO:0043657) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 
Secretory-pathway Annulate lamellae (GO:0005642) 0.8 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
1

Q5S007

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat serine/threonine-protein kinase 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Neuronal cell body (GO:0043025) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Perikaryon (GO:0043204) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Intracellular (GO:0005622) 1 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Inclusion body (GO:0016234) 1 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial matrix (GO:0005759) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Mitochondrion Mitochondrial membrane (GO:0031966) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion External side of mitochondrial outer membrane (GO:0032473) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial inner membrane (GO:0005743) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Golgi-associated vesicle (GO:0005798) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Trans-Golgi network (GO:0005802) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endosome (GO:0005768) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Multivesicular body, internal vesicle (GO:0097487) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Amphisome (GO:0044753) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Lysosome (GO:0005764) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Synaptic vesicle membrane (GO:0030672) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Growth cone (GO:0030426) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Microvillus (GO:0005902) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Neuron projection (GO:0043005) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Dendrite (GO:0030425) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Dendrite cytoplasm (GO:0032839) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Axon (GO:0030424) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular space (GO:0005615) 0.86 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Cell junction (GO:0030054) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Terminal button (GO:0043195) 1 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O43196

Interaction Score
1

P00519

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein kinase ABL1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell leading edge (GO:0031252) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Neuronal cell body (GO:0043025) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: non-traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Predicted: inferred from physical interaction GO PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 1 Unknown: traceable author statement GO PubMed 
Membrane Dendrite (GO:0030425) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Extrinsic to internal side of plasma membrane (GO:0031234) 0.937 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

O43196

Interaction Score
1

P14866

(UniProtKB/Swiss-Prot/P) Details

Heterogeneous nuclear ribonucleoprotein L

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Ribonucleoprotein complex (GO:0030529) 0.999 Experimental: experimental Organelle PubMed 
Cytosol Ribonucleoprotein granule (GO:0035770) 0.999 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
0.999

P13010

(UniProtKB/Swiss-Prot/P) Details

X-ray repair cross-complementing protein 5

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.958 Unknown: traceable author statement GO PubMed 
Cytosol Nonhomologous end joining complex (GO:0070419) 0.958 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Protein-DNA complex (GO:0032993) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear telomere cap complex (GO:0000783) 1 Unknown: traceable author statement GO PubMed 
Nucleus Ku70:Ku80 complex (GO:0043564) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Secretory granule lumen (GO:0034774) 0.3 Unknown: traceable author statement GO PubMed 
Nucleus Nuclear chromosome, telomeric region (GO:0000784) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.972 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
0.999

Q13227

(UniProtKB/Swiss-Prot/P) Details

G protein pathway suppressor 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.94 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.999 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Unknown: traceable author statement GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Transcriptional repressor complex (GO:0017053) 0.999 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
0.994

O15360

(UniProtKB/Swiss-Prot/P) Details

Fanconi anemia group A protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Unknown: traceable author statement GO PubMed 
Nucleus Fanconi anaemia nuclear complex (GO:0043240) 1 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
0.992

O15457

(UniProtKB/Swiss-Prot/P) Details

MutS protein homolog 4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Mismatch repair complex (GO:0032300) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Synaptonemal complex (GO:0000795) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

BioGRID, HPRD, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

O43196

Interaction Score
0.967

Q59FK4

(UniProtKB/TrEmbl/P) Details

Tyrosine-protein kinase

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
0.898

Q96EQ0

(UniProtKB/Swiss-Prot/P) Details

Small glutamine-rich tetratricopeptide repeat-containing protein beta

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.91 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

O43196

Interaction Score
0.694

Q6NTA2

(UniProtKB/TrEmbl/P) Details

HNRNPL protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015