O43513

Mediator of RNA polymerase II transcription subunit 7 // UniProt Profile

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Species	H. sapiens
Number of Interactions	82 / 112
Average Interaction Score	0.884

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Srb-mediator complex (GO:0016592)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Experimental: inferred from direct assay	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

O43513

Interaction Score

P03372

(UniProtKB/Swiss-Prot/P) Details

Estrogen receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	Transcriptional preinitiation complex (GO:0097550)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcriptionally active chromatin (GO:0035327)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.902	Unknown: non-traceable author statement	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

P29590

(UniProtKB/Swiss-Prot/P) Details

Protein PML

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.982	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.982	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	PML body (GO:0016605)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Extrinsic to endoplasmic reticulum membrane (GO:0042406)	0.79	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Heterochromatin (GO:0000792)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

Q12888

(UniProtKB/Swiss-Prot/P) Details

TP53-binding protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Site of double-strand break (GO:0035861)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Replication fork (GO:0005657)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome, telomeric region (GO:0000781)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43513

Interaction Score

Q04206

(UniProtKB/Swiss-Prot/P) Details

Transcription factor p65

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	I-kappaB/NF-kappaB complex (GO:0033256)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

Q9Y5B0

(UniProtKB/Swiss-Prot/P) Details

RNA polymerase II subunit A C-terminal domain phosphatase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	DNA-directed RNA polymerase II, holoenzyme (GO:0016591)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Spindle (GO:0005819)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

Q13503

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 21

O43513

Interaction Score

P49336

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinase 8

O43513

Interaction Score

Q9NVC6

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 17

O43513

Interaction Score

Q15648

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Srb-mediator complex (GO:0016592)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Protein-DNA complex (GO:0032993)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromatin (GO:0000785)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

O43513

Interaction Score

P09874

(UniProtKB/Swiss-Prot/P) Details

Poly [ADP-ribose] polymerase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Protein-DNA complex (GO:0032993)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

P41235

(UniProtKB/Swiss-Prot/P) Details

Hepatocyte nuclear factor 4-alpha

O43513

Interaction Score

Q9NPJ6

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 4

O43513

Interaction Score

Q6P2C8

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 27

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.992	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Srb-mediator complex (GO:0016592)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

O75586

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 6

O43513

Interaction Score

Q9BWU1

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent kinase 19

O43513

Interaction Score

P11473

(UniProtKB/Swiss-Prot/P) Details

Vitamin D3 receptor

O43513

Interaction Score

Q93074

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 12

O43513

Interaction Score

A0JLT2

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 19

O43513

Interaction Score

Q9UHV7

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 13

O43513

Interaction Score

O75448

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 24

O43513

Interaction Score

O60244

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 14

O43513

Interaction Score

Q96HR3

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 30

O43513

Interaction Score

Q9ULK4

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 23

O43513

Interaction Score

O43251

(UniProtKB/Swiss-Prot/P) Details

RNA binding protein fox-1 homolog 2

O43513

Interaction Score

Q9H944

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 20

O43513

Interaction Score

Q71SY5

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 25

O43513

Interaction Score

Q99814

(UniProtKB/Swiss-Prot/P) Details

Endothelial PAS domain-containing protein 1

O43513

Interaction Score

0.999

Q9UJW3

(UniProtKB/Swiss-Prot/P) Details

DNA (cytosine-5)-methyltransferase 3-like

O43513

Interaction Score

0.999

Q9H204

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 28

O43513

Interaction Score

0.999

Q9Y3C7

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 31

O43513

Interaction Score

0.999

Q71F56

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 13-like

O43513

Interaction Score

0.999

Q9Y2X0

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 16

O43513

Interaction Score

0.999

Q96RN5

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 15

O43513

Interaction Score

0.998

Q8NBB4

(UniProtKB/Swiss-Prot/P) Details

Zinc finger and SCAN domain-containing protein 1

O43513

Interaction Score

0.998

Q9Y6K9

(UniProtKB/Swiss-Prot/P) Details

NF-kappa-B essential modulator

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Predicted: inferred from physical interaction	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	IkappaB kinase complex (GO:0008385)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.997	Unknown: traceable author statement	GO	PubMed
Cytosol	Mitotic spindle (GO:0072686)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

0.998

O95402

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 26

O43513

Interaction Score

0.998

Q9BTT4

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 10

O43513

Interaction Score

0.997

Q9NX70

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 29

O43513

Interaction Score

0.997

Q96G25

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 8

O43513

Interaction Score

0.996

Q9BUE0

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 18

O43513

Interaction Score

0.994

Q9BZE3

(UniProtKB/Swiss-Prot/P) Details

BarH-like 1 homeobox protein

O43513

Interaction Score

0.994

Q86YW9

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 12-like protein

O43513

Interaction Score

0.994

Q15528

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 22

O43513

Interaction Score

0.994

Q9P086

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 11

O43513

Interaction Score

0.994

P24863

(UniProtKB/Swiss-Prot/P) Details

Cyclin-C

O43513

Interaction Score

0.993

Q92731

(UniProtKB/Swiss-Prot/P) Details

Estrogen receptor beta

O43513

Interaction Score

0.99

P63279

(UniProtKB/Swiss-Prot/P) Details

SUMO-conjugating enzyme UBC9

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Transferase complex (GO:1990234)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.986	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear envelope (GO:0005635)	0.986	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.986	Unknown: traceable author statement	GO	PubMed
Nucleus	PML body (GO:0016605)	0.986	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Synaptonemal complex (GO:0000795)	0.986	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

0.99

P36956

(UniProtKB/Swiss-Prot/P) Details

Sterol regulatory element-binding protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.992	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.986	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.986	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear envelope (GO:0005635)	0.986	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.986	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.986	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.986	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.986	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.986	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43513

Interaction Score

0.987

Q9BQY4

(UniProtKB/Swiss-Prot/P) Details

Rhox homeobox family member 2

O43513

Interaction Score

0.987

Q14134

(UniProtKB/Swiss-Prot/P) Details

Tripartite motif-containing protein 29

O43513

Interaction Score

0.986

Q9NWA0

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 9

O43513

Interaction Score

0.96

J3KR33

(UniProtKB/TrEmbl/P) Details

Mediator of RNA polymerase II transcription subunit 19

O43513

Interaction Score

0.96

I3L3E8

(UniProtKB/TrEmbl/P) Details

Mediator of RNA polymerase II transcription subunit 11

O43513

Interaction Score

0.958

P51116

(UniProtKB/Swiss-Prot/P) Details

Fragile X mental retardation syndrome-related protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Ribonucleoprotein complex (GO:0030529)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Polysome (GO:0005844)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytosolic large ribosomal subunit (GO:0022625)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Experimental: experimental	Organelle	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

O43513

Interaction Score

0.954

A0A0A0MR03

(UniProtKB/TrEmbl/P) Details

RNA polymerase II subunit A C-terminal domain phosphatase

O43513

Interaction Score

0.953

Q9UBT1

(UniProtKB/TrEmbl/P) Details

Estrogen receptor

O43513

Interaction Score

0.94

B4DUA7

(UniProtKB/TrEmbl/P) Details

Intersex-like

O43513

Interaction Score

0.894

Q9H0N5

(UniProtKB/Swiss-Prot/P) Details

Pterin-4-alpha-carbinolamine dehydratase 2

O43513

Interaction Score

0.86

Q9NRG1

(UniProtKB/Swiss-Prot/P) Details

Phosphoribosyltransferase domain-containing protein 1

O43513

Interaction Score

0.86

Q9Y376

(UniProtKB/Swiss-Prot/P) Details

Calcium-binding protein 39

O43513

Interaction Score

0.848

H0Y4W6

(UniProtKB/TrEmbl/P) Details

Estrogen receptor

O43513

Interaction Score

0.848

E9PRL4

(UniProtKB/TrEmbl/P) Details

Tripartite motif-containing protein 29

O43513

Interaction Score

0.848

E5RFK5

(UniProtKB/TrEmbl/P) Details

Cyclin-C

O43513

Interaction Score

0.8

A0A087WXV4

(UniProtKB/TrEmbl/P) Details

Hepatocyte nuclear factor 4-alpha

O43513

Interaction Score

0.8

B9VVT8

(UniProtKB/TrEmbl/P) Details

HNF4alpha10/11/12

O43513

Interaction Score

0.8

Q7LCB3

(UniProtKB/TrEmbl/P) Details

5p152

O43513

Interaction Score

0.8

G3V1P5

(UniProtKB/TrEmbl/P) Details

Mediator of RNA polymerase II transcription subunit 15

O43513

Interaction Score

0.8

A0A087WYL7

(UniProtKB/TrEmbl/P) Details

Mediator of RNA polymerase II transcription subunit 6

O43513

Interaction Score

0.8

Q05DL5

(UniProtKB/TrEmbl/P) Details

MED23 protein

O43513

Interaction Score

0.784

Q9C019

(UniProtKB/Swiss-Prot/P) Details

Tripartite motif-containing protein 15

O43513

Interaction Score

0.763

Q5SRL0

(UniProtKB/TrEmbl/P) Details

Tripartite motif-containing 15

O43513

Interaction Score

0.763

Q7Z4L3

(UniProtKB/TrEmbl/P) Details

Cyclin C, isoform CRA_a

O43513

Interaction Score

0.7

Q0PTK2

(UniProtKB/TrEmbl/P) Details

Estrogen receptor beta 4

O43513

Interaction Score

0.7

Q6PKB8

(UniProtKB/TrEmbl/P) Details

Mediator of RNA polymerase II transcription subunit 15

O43513

Interaction Score

0.3

Q96CS2

(UniProtKB/Swiss-Prot/P) Details

HAUS augmin-like complex subunit 1

O43513

Interaction Score

0.3

O14964

(UniProtKB/Swiss-Prot/P) Details

Hepatocyte growth factor-regulated tyrosine kinase substrate

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Early endosome (GO:0005769)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Multivesicular body membrane (GO:0032585)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	ESCRT-0 complex (GO:0033565)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

O43513

Interaction Score

0.3

Q9BSL1

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-associated domain-containing protein 1

O43513

Interaction Score

0.297

Q8TBB1

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase LNX

O43513

Interaction Score

0.273

Q8N653

(UniProtKB/Swiss-Prot/P) Details

Leucine-zipper-like transcriptional regulator 1

O43513

Interaction Score

0.24

A0A087X1B1

(UniProtKB/TrEmbl/P) Details

NF-kappa-B essential modulator

O43513

Interaction Score

0.24

A0A087X0W8

(UniProtKB/TrEmbl/P) Details

Transcription factor p65

O43513

Interaction Score

0.24

B0QYN7

(UniProtKB/TrEmbl/P) Details

SUMO-conjugating enzyme UBC9

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O43513

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

O43513

P03372

Estrogen receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

P29590

Protein PML

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q12888

TP53-binding protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q04206

Transcription factor p65

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q9Y5B0

RNA polymerase II subunit A C-terminal domain phosphatase

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q13503

Mediator of RNA polymerase II transcription subunit 21

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

P49336

Cyclin-dependent kinase 8

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q9NVC6

Mediator of RNA polymerase II transcription subunit 17

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q15648

Mediator of RNA polymerase II transcription subunit 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

P09874

Poly [ADP-ribose] polymerase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

P41235

Hepatocyte nuclear factor 4-alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513

Q9NPJ6

Mediator of RNA polymerase II transcription subunit 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43513