O43612

Orexin    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 4 / 4

Average Interaction Score

 0.974

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.972 Experimental: experimental eSLDB PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: experimental Organelle PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.931 Experimental: experimental eSLDB PubMed 
Secretory-pathway Rough endoplasmic reticulum (GO:0005791) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Secretory granule (GO:0030141) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Synaptic vesicle (GO:0008021) 0.931 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental MatrixDB PubMed 
Cytosol Vesicle (GO:0031982) 0.972 Experimental: experimental eSLDB PubMed 
Membrane Cell junction (GO:0030054) 0.86 Unknown: inferred from electronic annotation GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

O43612

Interaction Score
1

P01909

(UniProtKB/Swiss-Prot/P) Details

HLA class II histocompatibility antigen, DQ alpha 1 chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.983 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556) 0.983 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.983 Unknown: traceable author statement GO PubMed 
Secretory-pathway Trans-Golgi network membrane (GO:0032588) 0.983 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome membrane (GO:0010008) 0.983 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Lysosome (GO:0005764) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Lysosomal membrane (GO:0005765) 0.937 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endocytic vesicle membrane (GO:0030666) 0.983 Unknown: traceable author statement GO PubMed 
Secretory-pathway ER to Golgi transport vesicle membrane (GO:0012507) 0.983 Unknown: traceable author statement GO PubMed 
Secretory-pathway Clathrin-coated endocytic vesicle membrane (GO:0030669) 0.983 Unknown: traceable author statement GO PubMed 
Secretory-pathway Transport vesicle membrane (GO:0030658) 0.983 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.94 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.94 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.996 Unknown: HDA GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Experimental: experimental Organelle PubMed 
Membrane MHC class II protein complex (GO:0042613) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.996 Unknown: non-traceable author statement GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

O43612

Interaction Score
0.999

Q9Y5X5

(UniProtKB/Swiss-Prot/P) Details

Neuropeptide FF receptor 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.999 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

O43612

Interaction Score
0.948

O43614

(UniProtKB/Swiss-Prot/P) Details

Orexin receptor type 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.999 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

O43612

Interaction Score
0.948

O43613

(UniProtKB/Swiss-Prot/P) Details

Orexin receptor type 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.997 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.997 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.997 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015