P00736

Complement C1r subcomponent    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 15 / 18

Average Interaction Score

 0.737

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.51 Unknown: unspecified method The Human Protein Atlas PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.971 Unknown: non-traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.971 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.971 Experimental: inferred from direct assay GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.971 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.51 Unknown: HDA GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P00736

Interaction Score
0.996

Q8TF66

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat-containing protein 15

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.958 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.988 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.988 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.988 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.992 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.958 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.982

P02746

(UniProtKB/Swiss-Prot/P) Details

Complement C1q subcomponent subunit B

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.978 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.978 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.978 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Complement component C1 complex (GO:0005602) 0.978 Unknown: traceable author statement GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.978 Unknown: HDA GO PubMed 
Extracellular Collagen (GO:0005581) 0.978 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.975

P09871

(UniProtKB/Swiss-Prot/P) Details

Complement C1s subcomponent

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.853 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.853 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Blood microparticle (GO:0072562) 0.853 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

HPRD, IntAct, BioGRID

Interaction Source Publication:

PubMed , PubMed , PubMed 

P00736

Interaction Score
0.972

P05155

(UniProtKB/Swiss-Prot/P) Details

Plasma protease C1 inhibitor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Platelet alpha granule lumen (GO:0031093) 0.79 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.897 Unknown: non-traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.897 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.897 Unknown: HDA GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.897 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.79 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.961

P02745

(UniProtKB/Swiss-Prot/P) Details

Complement C1q subcomponent subunit A

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.86 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.3 Unknown: unspecified method The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.86 Unknown: unspecified method The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.897 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.897 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Complement component C1 complex (GO:0005602) 0.897 Unknown: traceable author statement GO PubMed 
Extracellular Collagen (GO:0005581) 0.897 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.958

Q9NZP8

(UniProtKB/Swiss-Prot/P) Details

Complement C1r subcomponent-like protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.79 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.972 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.914

Q13490

(UniProtKB/Swiss-Prot/P) Details

Baculoviral IAP repeat-containing protein 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Fibrillar center (GO:0001650) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus XY body (GO:0001741) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane raft (GO:0045121) 0.937 Unknown: inferred from electronic annotation GO PubMed 
Membrane Internal side of plasma membrane (GO:0009898) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane CD40 receptor complex (GO:0035631) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.728

P68400

(UniProtKB/Swiss-Prot/P) Details

Casein kinase II subunit alpha

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.958 Unknown: traceable author statement GO PubMed 
Cytosol Protein kinase CK2 complex (GO:0005956) 0.958 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus NuRD complex (GO:0016581) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus PcG protein complex (GO:0031519) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Sin3 complex (GO:0016580) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.3 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.679

Q6P672

(UniProtKB/TrEmbl/P) Details

C1RL protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.586

Q09472

(UniProtKB/Swiss-Prot/P) Details

Histone acetyltransferase p300

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Transcription factor complex (GO:0005667) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Histone acetyltransferase complex (GO:0000123) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Protein-DNA complex (GO:0032993) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Chromosome (GO:0005694) 1 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.55

F8WCZ6

(UniProtKB/TrEmbl/P) Details

Complement C1s subcomponent

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.506

P35558

(UniProtKB/Swiss-Prot/P) Details

Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.991 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.991 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.991 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.991 Unknown: traceable author statement GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.991 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.49

F5GWF3

(UniProtKB/TrEmbl/P) Details

Complement C1r subcomponent-like protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.49

F5H7C8

(UniProtKB/TrEmbl/P) Details

Complement C1r subcomponent-like protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Microtubule cytoskeleton (GO:0015630) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P00736

Interaction Score
0.273

Q7Z6C1

(UniProtKB/TrEmbl/P) Details

EP300 protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.91 Predicted: pTarget method LOCATE PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015