P01031

Complement C5    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 17 / 23

Average Interaction Score

 0.819

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.853 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.853 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.853 Unknown: traceable author statement GO PubMed 
Membrane Membrane (GO:0016020) 0.96 Experimental: experimental MatrixDB PubMed 
Membrane Membrane attack complex (GO:0005579) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P01031

Interaction Score
0.996

P15169

(UniProtKB/Swiss-Prot/P) Details

Carboxypeptidase N catalytic chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.982 Experimental: experimental eSLDB PubMed 
Cytosol Neuronal cell body (GO:0043025) 0.7 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleus (GO:0005634) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Secretory-pathway Secretory granule (GO:0030141) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.987 Experimental: experimental eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.987 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.987 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.987 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Membrane (GO:0016020) 0.94 Experimental: experimental MatrixDB PubMed 
Membrane Synaptic membrane (GO:0097060) 0.94 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.994

P07358

(UniProtKB/Swiss-Prot/P) Details

Complement component C8 beta chain

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.972 Unknown: traceable author statement GO PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: experimental MatrixDB PubMed 
Membrane Membrane attack complex (GO:0005579) 0.972 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.994

Q96BA8

(UniProtKB/Swiss-Prot/P) Details

Cyclic AMP-responsive element-binding protein 3-like protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.995 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.995 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.995 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.86 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum membrane (GO:0005789) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Lysosome (GO:0005764) 0.94 Predicted: pTarget method LOCATE PubMed 
Nucleus Nuclear chromatin (GO:0000790) 0.995 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.972 Experimental: inferred from direct assay GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.972 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.994

O15173

(UniProtKB/Swiss-Prot/P) Details

Membrane-associated progesterone receptor component 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytosol (GO:0005829) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear body (GO:0016604) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.987 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.987 Predicted: SVM decision tree eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.987 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.987 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.993

P13671

(UniProtKB/Swiss-Prot/P) Details

Complement component C6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.937 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.937 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.937 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.96 Experimental: experimental MatrixDB PubMed 
Membrane Membrane attack complex (GO:0005579) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.992

Q8N4V1

(UniProtKB/Swiss-Prot/P) Details

Membrane magnesium transporter 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Secretory-pathway ER membrane protein complex (GO:0072546) 0.999 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Early endosome (GO:0005769) 0.999 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Early endosome membrane (GO:0031901) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.958 Unknown: HDA GO PubMed 
Membrane Integral to membrane (GO:0016021) 0.958 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.958 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.992

P21730

(UniProtKB/Swiss-Prot/P) Details

C5a anaphylatoxin chemotactic receptor 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Cell surface (GO:0009986) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Apical part of cell (GO:0045177) 0.8 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Secretory granule membrane (GO:0030667) 0.3 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.999 Unknown: traceable author statement GO PubMed 
Membrane Basolateral plasma membrane (GO:0016323) 0.999 Experimental: inferred from direct assay GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.992

P01024

(UniProtKB/Swiss-Prot/P) Details

Complement C3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.897 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.86 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum lumen (GO:0005788) 0.897 Unknown: traceable author statement GO PubMed 
Secretory-pathway Secretory granule lumen (GO:0034774) 0.897 Unknown: traceable author statement GO PubMed 
Secretory-pathway Azurophil granule lumen (GO:0035578) 0.897 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.969 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.969 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.969 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.969 Unknown: HDA GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.969 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: traceable author statement GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.86 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.99

P23276

(UniProtKB/Swiss-Prot/P) Details

Kell blood group glycoprotein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoskeleton (GO:0005856) 0.96 Experimental: experimental eSLDB PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.96 Experimental: experimental Organelle PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.994 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.994 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Experimental: experimental Organelle PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.988

P10643

(UniProtKB/Swiss-Prot/P) Details

Complement component C7

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.96 Experimental: experimental MatrixDB PubMed 
Membrane Membrane attack complex (GO:0005579) 0.96 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID, HPRD

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.984

Q96IY4

(UniProtKB/Swiss-Prot/P) Details

Carboxypeptidase B2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cell (GO:0005623) 0.51 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.981 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.981 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.981 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.981 Predicted: inferred from biological aspect of ancestor GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.51 Unknown: HDA GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.973

Q7Z7G2

(UniProtKB/Swiss-Prot/P) Details

Complexin-4

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.931 Experimental: experimental eSLDB PubMed 
Membrane Membrane (GO:0016020) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Membrane Synapse (GO:0045202) 0.931 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.778

P02545

(UniProtKB/Swiss-Prot/P) Details

Prelamin-A/C

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.998 Experimental: experimental Organelle PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Unknown: HDA GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Lamin filament (GO:0005638) 1 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear membrane (GO:0031965) 1 Unknown: HDA GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear speck (GO:0016607) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.998 Experimental: experimental Organelle PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Organelle inner membrane (GO:0019866) 0.998 Experimental: experimental Organelle PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.56

Q53HP3

(UniProtKB/TrEmbl/P) Details

Complement component 2 variant

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.8 Experimental: experimental eSLDB PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.49

Q05CI3

(UniProtKB/TrEmbl/P) Details

C7 protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0.21

Q5TCI8

(UniProtKB/TrEmbl/P) Details

Prelamin-A/C

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P01031

Interaction Score
0

P78424

(UniProtKB/Swiss-Prot/P) Details

POU domain, class 6, transcription factor 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleus (GO:0005634) 0.996 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015