P01583

Interleukin-1 alpha    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 12 / 15

Average Interaction Score

 0.927

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.8 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.8 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.958 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P01583

Interaction Score
0.999

Q9NPH3

(UniProtKB/Swiss-Prot/P) Details

Interleukin-1 receptor accessory protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.8 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.996 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.996 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.996 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.998

O00165

(UniProtKB/Swiss-Prot/P) Details

HCLS1-associated protein X-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Endomembrane system (GO:0012505) 0.996 Experimental: experimental Organelle PubMed 
Cytosol Sarcoplasmic reticulum (GO:0016529) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasmic mRNA processing body (GO:0000932) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cell cortex (GO:0005938) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental eSLDB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrion (GO:0005739) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrial intermembrane space (GO:0005758) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrial outer membrane (GO:0005741) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.996 Experimental: experimental Organelle PubMed 
Nucleus Nuclear membrane (GO:0031965) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.996 Unknown: traceable author statement GO PubMed 
Nucleus Transcription factor complex (GO:0005667) 0.996 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.992 Experimental: experimental Organelle PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.992 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.996 Experimental: experimental Organelle PubMed 
Cytosol Actin cytoskeleton (GO:0015629) 0.996 Predicted: inferred from sequence or structural similarity GO PubMed 
Membrane Lamellipodium (GO:0030027) 0.958 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.958 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.958 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

DIP, HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed , PubMed , PubMed 

P01583

Interaction Score
0.993

P07384

(UniProtKB/Swiss-Prot/P) Details

Calpain-1 catalytic subunit

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Lysosome (GO:0005764) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.994 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.994 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.994 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Focal adhesion (GO:0005925) 0.994 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.993

Q99584

(UniProtKB/Swiss-Prot/P) Details

Protein S100-A13

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Mast cell granule (GO:0042629) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: HDA GO PubMed 
Extracellular Extracellular space (GO:0005615) 0.86 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.992 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.987

P29466

(UniProtKB/Swiss-Prot/P) Details

Caspase-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Protease inhibitor complex (GO:0097179) 0.86 Experimental: inferred from mutant phenotype GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: pTarget method LOCATE PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol AIM2 inflammasome complex (GO:0097169) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol NLRP3 inflammasome complex (GO:0072559) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol IPAF inflammasome complex (GO:0072557) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol NLRP1 inflammasome complex (GO:0072558) 1 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.988 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.988 Experimental: inferred from mutant phenotype GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

IntAct, HPRD

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.987

P27930

(UniProtKB/Swiss-Prot/P) Details

Interleukin-1 receptor type 2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.958 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Membrane (GO:0016020) 0.98 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.98 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.98 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.98 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

IntAct, DIP, BioGRID, HPRD

Interaction Source Publication:

PubMed , PubMed , PubMed 

P01583

Interaction Score
0.965

P14778

(UniProtKB/Swiss-Prot/P) Details

Interleukin-1 receptor type 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 1 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 1 Experimental: experimental eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 1 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Plasma membrane (GO:0005886) 1 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane External side of plasma membrane (GO:0009897) 1 Unknown: inferred from electronic annotation GO PubMed 
Membrane Integral to plasma membrane (GO:0005887) 1 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.964

O60684

(UniProtKB/Swiss-Prot/P) Details

Importin subunit alpha-7

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.995 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.995 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.995 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 0.995 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear pore (GO:0005643) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.982 Predicted: inferred from biological aspect of ancestor GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.982 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.905

Q9H0F6

(UniProtKB/Swiss-Prot/P) Details

Sharpin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol LUBAC complex (GO:0071797) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Lysosome (GO:0005764) 1 Predicted: pTarget method LOCATE PubMed 
Membrane Dendrite (GO:0030425) 0.657 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic density (GO:0014069) 0.657 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell junction (GO:0030054) 0.657 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.846

Q99608

(UniProtKB/Swiss-Prot/P) Details

Necdin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Perikaryon (GO:0043204) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.996 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.996 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Centrosome (GO:0005813) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Membrane Cell projection (GO:0042995) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID, HPRD

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.844

O00221

(UniProtKB/Swiss-Prot/P) Details

NF-kappa-B inhibitor epsilon

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.994 Unknown: traceable author statement GO PubMed 
Cytosol Cytosol (GO:0005829) 0.994 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.994 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Fibrillar center (GO:0001650) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Fibrillar center (GO:0001650) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P01583

Interaction Score
0.64

P50222

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein MOX-2

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.8 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Experimental: experimental eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nuclear speck (GO:0016607) 0.997 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015