P04731

Metallothionein-1A    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 5 / 5

Average Interaction Score

 0.924

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Cytosol Cytosol (GO:0005829) 0.937 Unknown: traceable author statement GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 0.937 Predicted: inferred from sequence or structural similarity GO PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: inferred from sequence or structural similarity GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P04731

Interaction Score
0.992

P49407

(UniProtKB/Swiss-Prot/P) Details

Beta-arrestin-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Coated pit (GO:0005905) 0.986 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.986 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.986 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytosol (GO:0005829) 0.986 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Golgi membrane (GO:0000139) 0.931 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endosome (GO:0005768) 0.931 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Lysosomal membrane (GO:0005765) 0.986 Unknown: traceable author statement GO PubMed 
Secretory-pathway Cytoplasmic vesicle (GO:0031410) 0.931 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Cytoplasmic vesicle membrane (GO:0030659) 0.931 Unknown: traceable author statement GO PubMed 
Nucleus Chromatin (GO:0000785) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Pseudopodium (GO:0031143) 0.984 Unknown: inferred from electronic annotation GO PubMed 
Membrane Dendritic spine (GO:0043197) 0.984 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic density (GO:0014069) 0.984 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.984 Unknown: traceable author statement GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.984 Experimental: experimental Organelle PubMed 
Membrane Heterotrimeric G-protein complex (GO:0005834) 0.984 Unknown: traceable author statement GO PubMed 
Membrane Basolateral plasma membrane (GO:0016323) 0.984 Unknown: inferred from electronic annotation GO PubMed 
Membrane Postsynaptic membrane (GO:0045211) 0.984 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P04731

Interaction Score
0.992

P63096

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(i) subunit alpha-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Membrane Midbody (GO:0030496) 0.999 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.7 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.8 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Lysosomal membrane (GO:0005765) 1 Unknown: HDA GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Centrosome (GO:0005813) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane raft (GO:0045121) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Heterotrimeric G-protein complex (GO:0005834) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P04731

Interaction Score
0.985

P04637

(UniProtKB/Swiss-Prot/P) Details

Cellular tumor antigen p53

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Intracellular (GO:0005622) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 0.998 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.972 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.972 Experimental: experimental Organelle PubMed 
Mitochondrion Mitochondrial matrix (GO:0005759) 0.972 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Organelle PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleolus (GO:0005730) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear matrix (GO:0016363) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus PML body (GO:0016605) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Transcription factor TFIID complex (GO:0005669) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Macromolecular complex (GO:0032991) 1 Experimental: inferred from mutant phenotype GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nuclear chromatin (GO:0000790) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Replication fork (GO:0005657) 1 Predicted: inferred from biological aspect of ancestor GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P04731

Interaction Score
0.98

Q14657

(UniProtKB/Swiss-Prot/P) Details

EKC/KEOPS complex subunit LAGE3

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Cytosol EKC/KEOPS complex (GO:0000408) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 1 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleus (GO:0005634) 1 Predicted: pTarget method LOCATE PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nuclear body (GO:0016604) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P04731

Interaction Score
0.672

Q13585

(UniProtKB/Swiss-Prot/P) Details

Melatonin-related receptor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleoplasm (GO:0005654) 0.96 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: experimental Organelle PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Membrane Plasma membrane (GO:0005886) 0.999 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Membrane Integral to plasma membrane (GO:0005887) 0.999 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015