P06870

Kallikrein-1    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 3 / 4

Average Interaction Score

 0.93

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleus (GO:0005634) 0.8 Experimental: inferred from direct assay GO PubMed 
Cytosol Lysosome (GO:0005764) 0.79 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.79 Unknown: HDA GO PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P06870

Interaction Score
0.989

P05154

(UniProtKB/Swiss-Prot/P) Details

Plasma serine protease inhibitor

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.988 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Protein C inhibitor-coagulation factor V complex (GO:0097181) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-coagulation factor Xa complex (GO:0097182) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-coagulation factor XI complex (GO:0097183) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-KLK3 complex (GO:0036029) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-plasma kallikrein complex (GO:0036030) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-PLAT complex (GO:0036026) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-PLAU complex (GO:0036027) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-thrombin complex (GO:0036028) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-TMPRSS11E complex (GO:0036025) 1 Experimental: inferred from direct assay GO PubMed 
Extracellular Protein C inhibitor-TMPRSS7 complex (GO:0036024) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Platelet dense tubular network (GO:0031094) 0.86 Experimental: inferred from direct assay GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Macromolecular complex (GO:0032991) 0.8 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Platelet alpha granule (GO:0031091) 0.988 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Acrosomal membrane (GO:0002080) 0.988 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular region (GO:0005576) 1 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 1 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular region (GO:0005576) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 1 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: inferred from direct assay GO PubMed 
Membrane Membrane (GO:0016020) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane External side of plasma membrane (GO:0009897) 0.992 Experimental: inferred from direct assay GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.86 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P06870

Interaction Score
0.907

P01042

(UniProtKB/Swiss-Prot/P) Details

Kininogen-1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.853 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum lumen (GO:0005788) 0.853 Unknown: traceable author statement GO PubMed 
Secretory-pathway Platelet alpha granule lumen (GO:0031093) 0.853 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.994 Unknown: non-traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.994 Experimental: inferred from direct assay GO PubMed 
Extracellular Blood microparticle (GO:0072562) 0.994 Unknown: HDA GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.994 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Plasma membrane (GO:0005886) 0.86 Unknown: traceable author statement GO PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

P06870

Interaction Score
0.895

P29622

(UniProtKB/Swiss-Prot/P) Details

Kallistatin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.94 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 0.94 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular region (GO:0005576) 0.853 Unknown: HDA GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.853 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.853 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed , PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015