P14091

Cathepsin E // UniProt Profile

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Species	H. sapiens
Number of Interactions	14 / 17
Average Interaction Score	0.712

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.94	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P14091

Interaction Score

0.973

P01308

(UniProtKB/Swiss-Prot/P) Details

Insulin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.984	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.984	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	0.984	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.984	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.984	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome lumen (GO:0031904)	0.984	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.984	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.984	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: inferred by curator	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.987	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P14091

Interaction Score

0.941

Q6Y288

(UniProtKB/Swiss-Prot/P) Details

Beta-1,3-glucosyltransferase

P14091

Interaction Score

0.94

P01023

(UniProtKB/Swiss-Prot/P) Details

Alpha-2-macroglobulin

P14091

Interaction Score

0.937

P62879

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.99	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cell body (GO:0044297)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.993	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.993	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.993	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.993	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.99	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.99	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.99	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.99	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Vesicle (GO:0031982)	0.993	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.993	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.99	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P14091

Interaction Score

0.93

P46379

(UniProtKB/Swiss-Prot/P) Details

Large proline-rich protein BAG6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	BAT3 complex (GO:0071818)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.958	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

HPRD, IntAct, BioGRID

Interaction Source Publication:

PubMed

P14091

Interaction Score

0.929

P14138

(UniProtKB/Swiss-Prot/P) Details

Endothelin-3

P14091

Interaction Score

0.892

O14757

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase Chk1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Condensed nuclear chromosome (GO:0000794)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromatin (GO:0000785)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Chromosome, telomeric region (GO:0000781)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.3	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P14091

Interaction Score

0.78

Q8NC69

(UniProtKB/Swiss-Prot/P) Details

BTB/POZ domain-containing protein KCTD6

P14091

Interaction Score

0.699

Q96QG7

(UniProtKB/Swiss-Prot/P) Details

Myotubularin-related protein 9

P14091

Interaction Score

0.694

Q9Y217

(UniProtKB/Swiss-Prot/P) Details

Myotubularin-related protein 6

P14091

Interaction Score

0.687

Q92979

(UniProtKB/Swiss-Prot/P) Details

Ribosomal RNA small subunit methyltransferase NEP1

P14091

Interaction Score

0.56

E7EPP6

(UniProtKB/TrEmbl/P) Details

Serine/threonine-protein kinase Chk1

P14091

Interaction Score

O60563

(UniProtKB/Swiss-Prot/P) Details

Cyclin-T1

P14091

Interaction Score

Q6FHM2

(UniProtKB/TrEmbl/P) Details

GNB2 protein

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P14091

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P14091

P01308

Insulin

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

Q6Y288

Beta-1,3-glucosyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

P01023

Alpha-2-macroglobulin

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

P62879

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

P46379

Large proline-rich protein BAG6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

P14138

Endothelin-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

O14757

Serine/threonine-protein kinase Chk1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

Q8NC69

BTB/POZ domain-containing protein KCTD6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

Q96QG7

Myotubularin-related protein 9

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

Q9Y217

Myotubularin-related protein 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

Q92979

Ribosomal RNA small subunit methyltransferase NEP1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091

E7EPP6

Serine/threonine-protein kinase Chk1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P14091