P14222

Perforin-1    //   UniProt Profile 

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Species

 H. sapiens

Number of Interactions

 10 / 11

Average Interaction Score

 0.979

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Secretory-pathway Endosome lumen (GO:0031904) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytolytic granule (GO:0044194) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.86 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.996 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.996 Experimental: experimental MatrixDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Experimental: experimental eSLDB PubMed 
Membrane Integral to membrane (GO:0016021) 0.996 Experimental: inferred from direct assay GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.996 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: experimental eSLDB PubMed 

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.


Interactions

All Details

P14222

Interaction Score
1

P27797

(UniProtKB/Swiss-Prot/P) Details

Calreticulin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 1 Experimental: experimental eSLDB PubMed 
Membrane Cell surface (GO:0009986) 0.952 Unknown: traceable author statement GO PubMed 
Cytosol Intracellular (GO:0005622) 1 Unknown: traceable author statement GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 1 Experimental: experimental Organelle PubMed 
Cytosol Sarcoplasmic reticulum lumen (GO:0033018) 1 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Polysome (GO:0005844) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytosol (GO:0005829) 1 Experimental: inferred from direct assay GO PubMed 
Cytosol Perinuclear region of cytoplasm (GO:0048471) 1 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Unknown: HDA GO PubMed 
Nucleus Nuclear envelope (GO:0005635) 0.86 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: experimental eSLDB PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Experimental: experimental Organelle PubMed 
Secretory-pathway Endoplasmic reticulum (GO:0005783) 1 Predicted: PAML algorithm PA-GOSUB PubMed 
Secretory-pathway Smooth endoplasmic reticulum (GO:0005790) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum lumen (GO:0005788) 1 Experimental: inferred from direct assay GO PubMed 
Secretory-pathway Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway MHC class I peptide loading complex (GO:0042824) 1 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Endoplasmic reticulum quality control compartment (GO:0044322) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 1 Unknown: inferred from electronic annotation GO PubMed 
Secretory-pathway Endocytic vesicle lumen (GO:0071682) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Phagocytic vesicle membrane (GO:0030670) 1 Unknown: traceable author statement GO PubMed 
Secretory-pathway Acrosomal vesicle (GO:0001669) 1 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.997 Experimental: experimental eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.997 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.997 Experimental: experimental MatrixDB PubMed 
Extracellular Extracellular space (GO:0005615) 0.997 Unknown: HDA GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.997 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.997 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.952 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.952 Experimental: experimental MatrixDB PubMed 
Membrane External side of plasma membrane (GO:0009897) 0.952 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Vesicle (GO:0031982) 1 Experimental: experimental eSLDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 1 Unknown: HDA GO PubMed 
Membrane Focal adhesion (GO:0005925) 0.952 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed 

P14222

Interaction Score
1

Q15323

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Experimental: experimental Human Proteinpedia PubMed 
Cytosol Cytoplasm (GO:0005737) 0.999 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.999 Unknown: traceable author statement GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.999 Experimental: experimental Organelle PubMed 
Cytosol Intermediate filament (GO:0005882) 0.999 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: pTarget method LOCATE PubMed 
Extracellular Extracellular space (GO:0005615) 0.79 Unknown: HDA GO PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.999 Unknown: HDA GO PubMed 

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.997

Q9NRD1

(UniProtKB/Swiss-Prot/P) Details

F-box only protein 6

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol SCF ubiquitin ligase complex (GO:0019005) 0.997 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Experimental: inferred from direct assay GO PubMed 
Cytosol Cytoplasm (GO:0005737) 0.997 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Cytosol (GO:0005829) 0.997 Unknown: traceable author statement GO PubMed 
Secretory-pathway Endoplasmic reticulum quality control compartment (GO:0044322) 0.3 Unknown: inferred from electronic annotation GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.995

P10144

(UniProtKB/Swiss-Prot/P) Details

Granzyme B

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.91 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.79 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytosol (GO:0005829) 0.79 Unknown: traceable author statement GO PubMed 
Mitochondrion Mitochondrion (GO:0005739) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Unknown: traceable author statement GO PubMed 
Nucleus Nucleus (GO:0005634) 0.86 Experimental: experimental Organelle PubMed 
Secretory-pathway Secretory granule (GO:0030141) 0.91 Predicted: inferred from biological aspect of ancestor GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.902 Unknown: HDA GO PubMed 
Membrane Plasma membrane (GO:0005886) 0.902 Experimental: experimental Organelle PubMed 
Membrane Immunological synapse (GO:0001772) 0.902 Unknown: traceable author statement GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.994

P10124

(UniProtKB/Swiss-Prot/P) Details

Serglycin

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.958 Predicted: SVM decision tree eSLDB PubMed 
Secretory-pathway Golgi apparatus (GO:0005794) 0.958 Experimental: inferred from direct assay GO PubMed 
Cytosol Mast cell granule (GO:0042629) 0.7 Predicted: inferred from sequence or structural similarity GO PubMed 
Secretory-pathway Platelet alpha granule lumen (GO:0031093) 0.958 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.992 Unknown: traceable author statement GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.992 Predicted: PAML algorithm PA-GOSUB PubMed 
Extracellular Extracellular space (GO:0005615) 0.992 Experimental: inferred from direct assay GO PubMed 
Extracellular Extracellular matrix (GO:0031012) 0.992 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.993

Q9BYV2

(UniProtKB/Swiss-Prot/P) Details

Tripartite motif-containing protein 54

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.994 Predicted: PAML algorithm PA-GOSUB PubMed 
Nucleus Nucleus (GO:0005634) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 
Cytosol Z disc (GO:0030018) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Cytoskeleton (GO:0005856) 0.994 Experimental: experimental Organelle PubMed 
Cytosol Microtubule associated complex (GO:0005875) 0.994 Unknown: inferred from electronic annotation GO PubMed 
Cytosol Microtubule (GO:0005874) 0.994 Unknown: non-traceable author statement GO PubMed 

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.987

Q9GZR7

(UniProtKB/Swiss-Prot/P) Details

ATP-dependent RNA helicase DDX24

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.94 Predicted: inferred from biological aspect of ancestor GO PubMed 
Cytosol Cytosol (GO:0005829) 0.94 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nucleus (GO:0005634) 0.998 Predicted: SVM decision tree eSLDB PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: inferred from direct assay GO PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: experimental Human Proteinpedia PubMed 
Nucleus Nucleolus (GO:0005730) 0.998 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Extracellular Extracellular region (GO:0005576) 0.8 Experimental: experimental MatrixDB PubMed 
Membrane Membrane (GO:0016020) 0.3 Unknown: HDA GO PubMed 

Interaction Source Database:

HPRD, IntAct

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.977

A8MQ03

(UniProtKB/Swiss-Prot/P) Details

Cysteine-rich tail protein 1

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Membrane Midbody (GO:0030496) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Intracellular membrane-bounded organelle (GO:0043231) 0.86 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Nucleus Nuclear speck (GO:0016607) 0.8 Experimental: annotated protein expression (APE) The Human Protein Atlas PubMed 
Cytosol Extracellular vesicular exosome (GO:0070062) 0.86 Unknown: HDA GO PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.964

Q7Z3S9

(UniProtKB/Swiss-Prot/P) Details

Notch homolog 2 N-terminal-like protein

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Secretory-pathway Secretory pathway (GO:secretory_pathway) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Cytosol Cytoplasm (GO:0005737) 0.3 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Unknown: inferred from electronic annotation GO PubMed 
Extracellular Extracellular region (GO:0005576) 0.79 Predicted: pTarget method LOCATE PubMed 
Membrane Membrane (GO:0016020) 0.8 Experimental: experimental MatrixDB PubMed 

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed 

P14222

Interaction Score
0.88

Q67BC3

(UniProtKB/TrEmbl/P) Details

Endogenous granzyme B

Localizations:

Major Localization Minor Localization Localization Score Experiment Type Source Database PubMed ID
Cytosol Cytoplasm (GO:0005737) 0.7 Predicted: SVM decision tree eSLDB PubMed 
Extracellular Extracellular region (GO:0005576) 0.7 Predicted: PAML algorithm PA-GOSUB PubMed 

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed 

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ComPPI is published in Nucleic Acids Research Database Issue 2015