P42898

Methylenetetrahydrofolate reductase // UniProt Profile

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Species	H. sapiens
Number of Interactions	27 / 31
Average Interaction Score	0.877

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.91	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.91	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Cell junction (GO:0030054)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Synapse (GO:0045202)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P42898

Interaction Score

P63096

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(i) subunit alpha-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Unknown: HDA	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Heterotrimeric G-protein complex (GO:0005834)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.999

P26439

(UniProtKB/Swiss-Prot/P) Details

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.997	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.96	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.996	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrial intermembrane space (GO:0005758)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrial membrane (GO:0031966)	0.996	Unknown: non-traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.997	Unknown: non-traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.997	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Smooth endoplasmic reticulum membrane (GO:0030868)	0.997	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.997	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.96	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.999

P19086

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(z) subunit alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cell body (GO:0044297)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.972	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.972	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear envelope (GO:0005635)	0.972	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.86	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.86	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Dendrite (GO:0030425)	0.971	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Experimental: experimental	Organelle	PubMed
Membrane	Heterotrimeric G-protein complex (GO:0005834)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.997

O43521

(UniProtKB/Swiss-Prot/P) Details

Bcl-2-like protein 11

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Bcl-2 family protein complex (GO:0097136)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.956	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.956	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.956	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	0.956	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.853	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	0.853	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Experimental: experimental	eSLDB	PubMed
Membrane	Extrinsic to membrane (GO:0019898)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.996

Q53HL2

(UniProtKB/Swiss-Prot/P) Details

Borealin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.987	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.987	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Spindle midzone (GO:0051233)	0.987	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Chromosome passenger complex (GO:0032133)	0.987	Predicted: inferred from physical interaction	GO	PubMed
Nucleus	Chromocenter (GO:0010369)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome, centromeric region (GO:0000775)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.96	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.994

A0PJW6

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 223

P42898

Interaction Score

0.989

Q9NRJ7

(UniProtKB/Swiss-Prot/P) Details

Protocadherin beta-16

P42898

Interaction Score

0.981

Q96SD1

(UniProtKB/Swiss-Prot/P) Details

Protein artemis

P42898

Interaction Score

0.972

Q9NS23

(UniProtKB/Swiss-Prot/P) Details

Ras association domain-containing protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	0.982	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.982	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.982	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Microtubule (GO:0005874)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.971

O95777

(UniProtKB/Swiss-Prot/P) Details

U6 snRNA-associated Sm-like protein LSm8

P42898

Interaction Score

0.97

Q17RP2

(UniProtKB/Swiss-Prot/P) Details

Tigger transposable element-derived protein 6

P42898

Interaction Score

0.969

O60906

(UniProtKB/Swiss-Prot/P) Details

Sphingomyelin phosphodiesterase 2

P42898

Interaction Score

0.965

Q8WWY3

(UniProtKB/Swiss-Prot/P) Details

U4/U6 small nuclear ribonucleoprotein Prp31

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	U4 snRNP (GO:0005687)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	U4/U6 x U5 tri-snRNP complex (GO:0046540)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	U4atac snRNP (GO:0005690)	0.972	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Cajal body (GO:0015030)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	MLL1 complex (GO:0071339)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Precatalytic spliceosome (GO:0071011)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	U2-type spliceosomal complex (GO:0005684)	1	Unknown: inferred by curator	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.929

Q96PH1

(UniProtKB/Swiss-Prot/P) Details

NADPH oxidase 5

P42898

Interaction Score

0.918

O14978

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 263

P42898

Interaction Score

0.888

P55107

(UniProtKB/Swiss-Prot/P) Details

Growth/differentiation factor 10

P42898

Interaction Score

0.868

Q8IY73

(UniProtKB/TrEmbl/P) Details

Guanine nucleotide binding protein (G protein), alpha z polypeptide

P42898

Interaction Score

0.858

P21709

(UniProtKB/Swiss-Prot/P) Details

Ephrin type-A receptor 1

P42898

Interaction Score

0.858

Q8TDN2

(UniProtKB/Swiss-Prot/P) Details

Potassium voltage-gated channel subfamily V member 2

P42898

Interaction Score

0.855

Q9HAH1

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 556

P42898

Interaction Score

0.815

A4D0W0

(UniProtKB/TrEmbl/P) Details

LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae), isoform CRA_b

P42898

Interaction Score

0.782

P05412

(UniProtKB/Swiss-Prot/P) Details

Transcription factor AP-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcriptional repressor complex (GO:0017053)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	AP1 complex (GO:0035976)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear chromosome (GO:0000228)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear euchromatin (GO:0005719)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P42898

Interaction Score

0.68

Q7Z5L4

(UniProtKB/Swiss-Prot/P) Details

Spermatogenesis-associated protein 19, mitochondrial

P42898

Interaction Score

0.637

A0A0C4DH20

(UniProtKB/TrEmbl/P) Details

Bcl-2-like protein 11

P42898

Interaction Score

0.637

A0A0A0MRE7

(UniProtKB/TrEmbl/P) Details

Bcl-2-like protein 11

P42898

Interaction Score

0.602

A3QRJ0

(UniProtKB/TrEmbl/P) Details

HCG2003451, isoform CRA_d

P42898

Interaction Score

0.56

A0A0C4DGQ3

(UniProtKB/TrEmbl/P) Details

Zinc finger protein 556, isoform CRA_b

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P42898

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P42898

P63096

Guanine nucleotide-binding protein G(i) subunit alpha-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

P26439

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

P19086

Guanine nucleotide-binding protein G(z) subunit alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

O43521

Bcl-2-like protein 11

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

Q53HL2

Borealin

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

A0PJW6

Transmembrane protein 223

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

Q9NRJ7

Protocadherin beta-16

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

Q96SD1

Protein artemis

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

Q9NS23

Ras association domain-containing protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

O95777

U6 snRNA-associated Sm-like protein LSm8

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

Q17RP2

Tigger transposable element-derived protein 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898

O60906

Sphingomyelin phosphodiesterase 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P42898