P43627

Killer cell immunoglobulin-like receptor 2DL2 // UniProt Profile

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Species	H. sapiens
Number of Interactions	38 / 42
Average Interaction Score	0.719

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Experimental: experimental	Organelle	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P43627

Interaction Score

0.997

Q9NPY3

(UniProtKB/Swiss-Prot/P) Details

Complement component C1q receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.902	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	0.902	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Tertiary granule membrane (GO:0070821)	0.902	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.988	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

P43627

Interaction Score

0.996

Q31612

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, B-73 alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.995	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.989	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.995	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.995	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.995	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P43627

Interaction Score

0.996

P17693

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, alpha chain G

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.882	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.994	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.994	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P43627

Interaction Score

0.996

Q95604

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-17 alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.989	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.973	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

P43627

Interaction Score

0.986

P43629

(UniProtKB/Swiss-Prot/P) Details

Killer cell immunoglobulin-like receptor 3DL1

P43627

Interaction Score

0.978

Q14943

(UniProtKB/Swiss-Prot/P) Details

Killer cell immunoglobulin-like receptor 3DS1

P43627

Interaction Score

0.969

Q9Y4K3

(UniProtKB/Swiss-Prot/P) Details

TNF receptor-associated factor 6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lipid particle (GO:0005811)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.7	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	0.982	Experimental: inferred from direct assay	GO	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	CD40 receptor complex (GO:0035631)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P43627

Interaction Score

0.968

Q29960

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-16 alpha chain

P43627

Interaction Score

0.962

P10321

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-7 alpha chain

P43627

Interaction Score

0.931

P30484

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, B-46 alpha chain

P43627

Interaction Score

0.902

Q15654

(UniProtKB/Swiss-Prot/P) Details

Thyroid receptor-interacting protein 6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.997	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.997	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.997	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.997	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Interleukin-1 receptor complex (GO:0045323)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P43627

Interaction Score

0.884

P30510

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-14 alpha chain

P43627

Interaction Score

0.884

P30504

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-4 alpha chain

P43627

Interaction Score

0.884

P30499

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-1 alpha chain

P43627

Interaction Score

0.884

P04222

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-3 alpha chain

P43627

Interaction Score

0.884

Q29865

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-18 alpha chain

P43627

Interaction Score

0.884

P30505

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-8 alpha chain

P43627

Interaction Score

0.884

P30501

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-2 alpha chain

P43627

Interaction Score

0.884

Q9TNN7

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-5 alpha chain

P43627

Interaction Score

0.884

Q29963

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-6 alpha chain

P43627

Interaction Score

0.884

Q07000

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-15 alpha chain

P43627

Interaction Score

0.884

P30508

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-12 alpha chain

P43627

Interaction Score

0.874

Q31611

(UniProtKB/TrEmbl/P) Details

B2 microglobulin

P43627

Interaction Score

0.848

Q95HC2

(UniProtKB/TrEmbl/P) Details

HLA-C protein

P43627

Interaction Score

0.848

Q6R739

(UniProtKB/TrEmbl/P) Details

HLA class I antigen

P43627

Interaction Score

0.819

P52292

(UniProtKB/Swiss-Prot/P) Details

Importin subunit alpha-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P43627

Interaction Score

0.722

Q8N6C9

(UniProtKB/TrEmbl/P) Details

KIR3DL1/S1

P43627

Interaction Score

0.722

Q6H2G3

(UniProtKB/TrEmbl/P) Details

KIR3DL1/S1

P43627

Interaction Score

0.722

Q5UCE2

(UniProtKB/TrEmbl/P) Details

KIR3DL1/S1

P43627

Interaction Score

0.722

Q6DU14

(UniProtKB/TrEmbl/P) Details

HLA-G histocompatibility antigen, class I, G, isoform CRA_a

P43627

Interaction Score

0.631

Q5RJ85

(UniProtKB/TrEmbl/P) Details

HLA class I histocompatibility antigen, alpha chain G

P43627

Interaction Score

Q6FHY5

(UniProtKB/TrEmbl/P) Details

MEOX2 protein

P43627

Interaction Score

Q99565

(UniProtKB/TrEmbl/P) Details

NK receptor

P43627

Interaction Score

Q4KN23

(UniProtKB/TrEmbl/P) Details

KIR3DS1 protein

P43627

Interaction Score

O43469

(UniProtKB/TrEmbl/P) Details

Killer cell immunoglobulin-like receptor 3DS1

P43627

Interaction Score

Q93062

(UniProtKB/Swiss-Prot/P) Details

RNA-binding protein with multiple splicing

P43627

Interaction Score

B4E3T4

(UniProtKB/TrEmbl/P) Details

HCG2043421, isoform CRA_c

P43627

Interaction Score

Q9NWF9

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase RNF216

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P43627

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P43627

Q9NPY3

Complement component C1q receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

Q31612

HLA class I histocompatibility antigen, B-73 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

P17693

HLA class I histocompatibility antigen, alpha chain G

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

Q95604

HLA class I histocompatibility antigen, Cw-17 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

P43629

Killer cell immunoglobulin-like receptor 3DL1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

Q14943

Killer cell immunoglobulin-like receptor 3DS1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

Q9Y4K3

TNF receptor-associated factor 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

Q29960

HLA class I histocompatibility antigen, Cw-16 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

P10321

HLA class I histocompatibility antigen, Cw-7 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

P30484

HLA class I histocompatibility antigen, B-46 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

Q15654

Thyroid receptor-interacting protein 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627

P30510

HLA class I histocompatibility antigen, Cw-14 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

P43627