P53701

Cytochrome c-type heme lyase // UniProt Profile

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Species	H. sapiens
Number of Interactions	69 / 99
Average Interaction Score	0.866

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.8	Experimental: experimental	Organelle	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

P53701

Interaction Score

O00483

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c oxidase subunit NDUFA4

P53701

Interaction Score

P23786

(UniProtKB/Swiss-Prot/P) Details

Carnitine O-palmitoyltransferase 2, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	0.8	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P53701

Interaction Score

Q53H12

(UniProtKB/Swiss-Prot/P) Details

Acylglycerol kinase, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial intermembrane space (GO:0005758)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial inner membrane protein insertion complex (GO:0042721)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	1	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Integral to mitochondrial inner membrane (GO:0031305)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P53701

Interaction Score

P13073

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

P53701

Interaction Score

P08574

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c1, heme protein, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrial respiratory chain complex III (GO:0005750)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.853	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.853	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.853	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P53701

Interaction Score

O95831

(UniProtKB/Swiss-Prot/P) Details

Apoptosis-inducing factor 1, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.79	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Unknown: HDA	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrial intermembrane space (GO:0005758)	0.998	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.998	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Experimental: experimental	Organelle	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P53701

Interaction Score

Q9Y6C9

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial carrier homolog 2

P53701

Interaction Score

Q9HCL2

(UniProtKB/Swiss-Prot/P) Details

Glycerol-3-phosphate acyltransferase 1, mitochondrial

P53701

Interaction Score

O75880

(UniProtKB/Swiss-Prot/P) Details

Protein SCO1 homolog, mitochondrial

P53701

Interaction Score

Q9P032

(UniProtKB/Swiss-Prot/P) Details

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

P53701

Interaction Score

Q9H9B4

(UniProtKB/Swiss-Prot/P) Details

Sideroflexin-1

P53701

Interaction Score

0.999

Q9NRX2

(UniProtKB/Swiss-Prot/P) Details

39S ribosomal protein L17, mitochondrial

P53701

Interaction Score

0.999

Q9NPL8

(UniProtKB/Swiss-Prot/P) Details

Complex I assembly factor TIMMDC1, mitochondrial

P53701

Interaction Score

0.999

Q96E11

(UniProtKB/Swiss-Prot/P) Details

Ribosome-recycling factor, mitochondrial

P53701

Interaction Score

0.996

Q96I36

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c oxidase assembly protein COX14

P53701

Interaction Score

0.996

Q9HC62

(UniProtKB/Swiss-Prot/P) Details

Sentrin-specific protease 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.998	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Pore complex (GO:0046930)	0.94	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear pore (GO:0005643)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	PML body (GO:0016605)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P53701

Interaction Score

0.995

O75208

(UniProtKB/Swiss-Prot/P) Details

Ubiquinone biosynthesis protein COQ9, mitochondrial

P53701

Interaction Score

0.991

P14854

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c oxidase subunit 6B1

P53701

Interaction Score

0.99

P21964

(UniProtKB/Swiss-Prot/P) Details

Catechol O-methyltransferase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cell body (GO:0044297)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosome (GO:0005764)	0.999	Predicted: pTarget method	LOCATE	PubMed
Membrane	Dendritic spine (GO:0043197)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.976	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.976	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.976	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	0.976	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P53701

Interaction Score

0.989

Q8WVC6

(UniProtKB/Swiss-Prot/P) Details

Dephospho-CoA kinase domain-containing protein

P53701

Interaction Score

0.985

P61106

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-14

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi stack (GO:0005795)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Unknown: HDA	GO	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Tertiary granule membrane (GO:0070821)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network transport vesicle (GO:0030140)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Cilium (GO:0005929)	0.982	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Secretory-pathway	Nuclear outer membrane-endoplasmic reticulum membrane network (GO:0042175)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.982	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P53701

Interaction Score

0.984

Q9UL25

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-21

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cleavage furrow (GO:0032154)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.996	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi cisterna membrane (GO:0032580)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.996	Unknown: HDA	GO	PubMed
Cytosol	Vesicle membrane (GO:0012506)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.971	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	0.971	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P53701

Interaction Score

0.983

Q13596

(UniProtKB/Swiss-Prot/P) Details

Sorting nexin-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Retromer complex (GO:0030904)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Retromer complex, outer shell (GO:0030905)	1	Predicted: inferred from physical interaction	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.8	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Lamellipodium (GO:0030027)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Experimental: inferred from direct assay	GO	PubMed
Membrane	Extrinsic to membrane (GO:0019898)	0.958	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

P53701

Interaction Score

0.983

Q9NVJ2

(UniProtKB/Swiss-Prot/P) Details

ADP-ribosylation factor-like protein 8B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.958	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.958	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P53701

Interaction Score

0.982

O95297

(UniProtKB/Swiss-Prot/P) Details

Myelin protein zero-like protein 1

P53701

Interaction Score

0.981

Q9UH62

(UniProtKB/Swiss-Prot/P) Details

Armadillo repeat-containing X-linked protein 3

P53701

Interaction Score

0.978

Q9H5K3

(UniProtKB/Swiss-Prot/P) Details

Protein O-mannose kinase

P53701

Interaction Score

0.977

P04062

(UniProtKB/Swiss-Prot/P) Details

Glucosylceramidase

P53701

Interaction Score

0.974

Q9NR82

(UniProtKB/Swiss-Prot/P) Details

Potassium voltage-gated channel subfamily KQT member 5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Voltage-gated potassium channel complex (GO:0008076)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Clathrin coat (GO:0030118)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P53701

Interaction Score

0.973

Q15738

(UniProtKB/Swiss-Prot/P) Details

Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lipid particle (GO:0005811)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lipid particle (GO:0005811)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.998	Unknown: traceable author statement	GO	PubMed
Cytosol	Peroxisome (GO:0005777)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P53701

Interaction Score

0.973

Q9H992

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase MARCH7

P53701

Interaction Score

0.972

Q8TC12

(UniProtKB/Swiss-Prot/P) Details

Retinol dehydrogenase 11

P53701

Interaction Score

0.96

A1L188

(UniProtKB/Swiss-Prot/P) Details

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8

P53701

Interaction Score

0.96

Q9H3N1

(UniProtKB/Swiss-Prot/P) Details

Thioredoxin-related transmembrane protein 1

P53701

Interaction Score

0.958

Q96C01

(UniProtKB/Swiss-Prot/P) Details

Protein FAM136A

P53701

Interaction Score

0.958

P61019

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-2A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.657	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.657	Unknown: HDA	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.94	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.657	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

P53701

Interaction Score

0.956

Q9BSJ8

(UniProtKB/Swiss-Prot/P) Details

Extended synaptotagmin-1

P53701

Interaction Score

0.951

Q96BN2

(UniProtKB/Swiss-Prot/P) Details

Transcriptional adapter 1

P53701

Interaction Score

0.945

O60664

(UniProtKB/Swiss-Prot/P) Details

Perilipin-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lipid particle (GO:0005811)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lipid particle (GO:0005811)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.76	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.76	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.76	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.76	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P53701

Interaction Score

0.945

Q8N3C0

(UniProtKB/Swiss-Prot/P) Details

Activating signal cointegrator 1 complex subunit 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.997	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

P53701

Interaction Score

0.945

Q15717

(UniProtKB/Swiss-Prot/P) Details

ELAV-like protein 1

P53701

Interaction Score

0.928

P30550

(UniProtKB/Swiss-Prot/P) Details

Gastrin-releasing peptide receptor

P53701

Interaction Score

0.928

Q9UHD4

(UniProtKB/Swiss-Prot/P) Details

Cell death activator CIDE-B

P53701

Interaction Score

0.923

P01568

(UniProtKB/Swiss-Prot/P) Details

Interferon alpha-21

P53701

Interaction Score

0.923

P01562

(UniProtKB/Swiss-Prot/P) Details

Interferon alpha-1/13

P53701

Interaction Score

0.921

Q9HBL7

(UniProtKB/Swiss-Prot/P) Details

Plasminogen receptor

P53701

Interaction Score

0.916

Q8NHH9

(UniProtKB/Swiss-Prot/P) Details

Atlastin-2

P53701

Interaction Score

0.91

Q9C002

(UniProtKB/Swiss-Prot/P) Details

Normal mucosa of esophagus-specific gene 1 protein

P53701

Interaction Score

0.908

Q6UUV7

(UniProtKB/Swiss-Prot/P) Details

CREB-regulated transcription coactivator 3

P53701

Interaction Score

0.891

Q14207

(UniProtKB/Swiss-Prot/P) Details

Protein NPAT

P53701

Interaction Score

0.886

Q9H813

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 206

P53701

Interaction Score

0.88

Q7Z614

(UniProtKB/Swiss-Prot/P) Details

Sorting nexin-20

P53701

Interaction Score

0.87

F5H6W4

(UniProtKB/TrEmbl/P) Details

E3 ubiquitin-protein ligase MARCH7

P53701

Interaction Score

0.8

Q9UKJ3

(UniProtKB/Swiss-Prot/P) Details

G patch domain-containing protein 8

P53701

Interaction Score

0.8

A0A1B0GTB8

(UniProtKB/TrEmbl/P) Details

Carnitine O-palmitoyltransferase 2, mitochondrial

P53701

Interaction Score

0.8

C9JU35

(UniProtKB/TrEmbl/P) Details

Complex I assembly factor TIMMDC1, mitochondrial

P53701

Interaction Score

0.8

E7EQY1

(UniProtKB/TrEmbl/P) Details

Protein FAM136A

P53701

Interaction Score

0.799

Q96G75

(UniProtKB/Swiss-Prot/P) Details

Protein RMD5 homolog B

P53701

Interaction Score

0.798

Q9NPA3

(UniProtKB/Swiss-Prot/P) Details

Mid1-interacting protein 1

P53701

Interaction Score

0.7

A4D1U5

(UniProtKB/TrEmbl/P) Details

Multiple substrate lipid kinase, isoform CRA_a

P53701

Interaction Score

0.64

Q86W50

(UniProtKB/Swiss-Prot/P) Details

U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

P53701

Interaction Score

0.64

A0A068F658

(UniProtKB/TrEmbl/P) Details

Glucosylceramidase

P53701

Interaction Score

0.632

Q9UM11

(UniProtKB/Swiss-Prot/P) Details

Fizzy-related protein homolog

P53701

Interaction Score

0.632

Q9BUL5

(UniProtKB/Swiss-Prot/P) Details

PHD finger protein 23

P53701

Interaction Score

0.56

Q8NDA8

(UniProtKB/Swiss-Prot/P) Details

Maestro heat-like repeat-containing protein family member 1

P53701

Interaction Score

Q8TEF4

(UniProtKB/TrEmbl/P) Details

FLJ00243 protein

P53701

Interaction Score

P12524

(UniProtKB/Swiss-Prot/P) Details

Protein L-Myc

P53701

Interaction Score

B5MCN0

(UniProtKB/TrEmbl/P) Details

Atlastin-2

P53701

Interaction Score

F5H6G4

(UniProtKB/TrEmbl/P) Details

Protein RMD5 homolog B

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P53701

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

P53701

O00483

Cytochrome c oxidase subunit NDUFA4

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

P23786

Carnitine O-palmitoyltransferase 2, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

Q53H12

Acylglycerol kinase, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

P13073

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

P08574

Cytochrome c1, heme protein, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

O95831

Apoptosis-inducing factor 1, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

Q9Y6C9

Mitochondrial carrier homolog 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

Q9HCL2

Glycerol-3-phosphate acyltransferase 1, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

O75880

Protein SCO1 homolog, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

Q9P032

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

Q9H9B4

Sideroflexin-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701

Q9NRX2

39S ribosomal protein L17, mitochondrial

Localizations:

Interaction Source Database:

Interaction Source Publication:

P53701