Q13325

Interferon-induced protein with tetratricopeptide repeats 5 // UniProt Profile

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Species	H. sapiens
Number of Interactions	39 / 52
Average Interaction Score	0.897

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Apical part of cell (GO:0045177)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	IkappaB kinase complex (GO:0008385)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q13325

Interaction Score

P49810

(UniProtKB/Swiss-Prot/P) Details

Presenilin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Neuronal cell body (GO:0043025)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.7	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear inner membrane (GO:0005637)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Integral to nuclear inner membrane (GO:0005639)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Kinetochore (GO:0000776)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Growth cone (GO:0030426)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Ciliary rootlet (GO:0035253)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane raft (GO:0045121)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Organelle inner membrane (GO:0019866)	1	Experimental: experimental	Organelle	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

P11532

(UniProtKB/Swiss-Prot/P) Details

Dystrophin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Costamere (GO:0043034)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Membrane	Filopodium (GO:0030175)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Filopodium membrane (GO:0031527)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuron projection terminus (GO:0044306)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dystrophin-associated glycoprotein complex (GO:0016010)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Syntrophin complex (GO:0016013)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Sarcolemma (GO:0042383)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lateral plasma membrane (GO:0016328)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Cell-substrate junction (GO:0030055)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

O15111

(UniProtKB/Swiss-Prot/P) Details

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	IkappaB kinase complex (GO:0008385)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Internal side of plasma membrane (GO:0009898)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	CD40 receptor complex (GO:0035631)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

Q9Y6K9

(UniProtKB/Swiss-Prot/P) Details

NF-kappa-B essential modulator

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Predicted: inferred from physical interaction	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	IkappaB kinase complex (GO:0008385)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.997	Unknown: traceable author statement	GO	PubMed
Cytosol	Mitotic spindle (GO:0072686)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

Q96SB4

(UniProtKB/Swiss-Prot/P) Details

SRSF protein kinase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear matrix (GO:0016363)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

Q8TEY7

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase 33

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	VCB complex (GO:0030891)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cell body (GO:0044297)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q13325

Interaction Score

O14920

(UniProtKB/Swiss-Prot/P) Details

Inhibitor of nuclear factor kappa-B kinase subunit beta

Q13325

Interaction Score

P02649

(UniProtKB/Swiss-Prot/P) Details

Apolipoprotein E

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.986	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.986	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.986	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.998	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.998	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endocytic vesicle lumen (GO:0071682)	0.998	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin-coated endocytic vesicle membrane (GO:0030669)	0.998	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.986	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Dendrite (GO:0030425)	0.986	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	1	Unknown: HDA	GO	PubMed
Extracellular	Low-density lipoprotein particle (GO:0034362)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Intermediate-density lipoprotein particle (GO:0034363)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Very-low-density lipoprotein particle (GO:0034361)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Chylomicron (GO:0042627)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	High-density lipoprotein particle (GO:0034364)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Discoidal high-density lipoprotein particle (GO:0034365)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.986	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.986	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.986	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.986	Unknown: HDA	GO	PubMed
Membrane	Synaptic cleft (GO:0043083)	0.986	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

P00533

(UniProtKB/Swiss-Prot/P) Details

Epidermal growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.972	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Clathrin coated vesicle membrane (GO:0030665)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	AP-2 adaptor complex (GO:0030122)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Shc-EGFR complex (GO:0070435)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

Q16543

(UniProtKB/Swiss-Prot/P) Details

Hsp90 co-chaperone Cdc37

Q13325

Interaction Score

P46109

(UniProtKB/Swiss-Prot/P) Details

Crk-like protein

Q13325

Interaction Score

P09914

(UniProtKB/Swiss-Prot/P) Details

Interferon-induced protein with tetratricopeptide repeats 1

Q13325

Interaction Score

Q15717

(UniProtKB/Swiss-Prot/P) Details

ELAV-like protein 1

Q13325

Interaction Score

P54725

(UniProtKB/Swiss-Prot/P) Details

UV excision repair protein RAD23 homolog A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Proteasome complex (GO:0000502)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

Q9Y2H9

(UniProtKB/Swiss-Prot/P) Details

Microtubule-associated serine/threonine-protein kinase 1

Q13325

Interaction Score

0.999

O14879

(UniProtKB/Swiss-Prot/P) Details

Interferon-induced protein with tetratricopeptide repeats 3

Q13325

Interaction Score

0.999

P78362

(UniProtKB/Swiss-Prot/P) Details

SRSF protein kinase 2

Q13325

Interaction Score

0.999

Q9H9Z2

(UniProtKB/Swiss-Prot/P) Details

Protein lin-28 homolog A

Q13325

Interaction Score

0.997

Q9H4P4

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase NRDP1

Q13325

Interaction Score

0.997

O43318

(UniProtKB/Swiss-Prot/P) Details

Mitogen-activated protein kinase kinase kinase 7

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.987	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.987	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	IkappaB kinase complex (GO:0008385)	0.987	Predicted: inferred from physical interaction	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.997	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.997	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Ada2/Gcn5/Ada3 transcription activator complex (GO:0005671)	0.997	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

0.994

P32119

(UniProtKB/Swiss-Prot/P) Details

Peroxiredoxin-2

Q13325

Interaction Score

0.992

Q9BQ95

(UniProtKB/Swiss-Prot/P) Details

Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

Q13325

Interaction Score

0.992

Q9H0A6

(UniProtKB/Swiss-Prot/P) Details

RING finger protein 32

Q13325

Interaction Score

0.984

P05161

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-like protein ISG15

Q13325

Interaction Score

0.978

Q96BY9

(UniProtKB/Swiss-Prot/P) Details

Store-operated calcium entry-associated regulatory factor

Q13325

Interaction Score

0.976

P01023

(UniProtKB/Swiss-Prot/P) Details

Alpha-2-macroglobulin

Q13325

Interaction Score

0.949

P36776

(UniProtKB/Swiss-Prot/P) Details

Lon protease homolog, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.8	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Mitochondrion	Mitochondrial nucleoid (GO:0042645)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q13325

Interaction Score

0.926

Q504U8

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q13325

Interaction Score

0.926

E9PFD7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q13325

Interaction Score

0.91

A1L0U9

(UniProtKB/TrEmbl/P) Details

DMD protein

Q13325

Interaction Score

0.8

A0A087X1B1

(UniProtKB/TrEmbl/P) Details

NF-kappa-B essential modulator

Q13325

Interaction Score

0.747

Q9NPJ6

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 4

Q13325

Interaction Score

0.7

Q5T765

(UniProtKB/TrEmbl/P) Details

Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a

Q13325

Interaction Score

0.7

Q4G0X0

(UniProtKB/TrEmbl/P) Details

DMD protein

Q13325

Interaction Score

0.64

F2YGG7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q13325

Interaction Score

0.64

E7BSV0

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q13325

Interaction Score

0.64

B7Z2I3

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q13325

Interaction Score

0.51

Q8NC69

(UniProtKB/Swiss-Prot/P) Details

BTB/POZ domain-containing protein KCTD6

Q13325

Interaction Score

G5E940

(UniProtKB/TrEmbl/P) Details

RING finger protein 32

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Q13325

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q13325

P49810

Presenilin-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

P11532

Dystrophin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

O15111

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

Q9Y6K9

NF-kappa-B essential modulator

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

Q96SB4

SRSF protein kinase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

Q8TEY7

Ubiquitin carboxyl-terminal hydrolase 33

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

O14920

Inhibitor of nuclear factor kappa-B kinase subunit beta

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

P02649

Apolipoprotein E

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

P00533

Epidermal growth factor receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

Q16543

Hsp90 co-chaperone Cdc37

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

P46109

Crk-like protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325

P09914

Interferon-induced protein with tetratricopeptide repeats 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q13325