Q15345

Leucine-rich repeat-containing protein 41 // UniProt Profile

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Species	H. sapiens
Number of Interactions	40 / 55
Average Interaction Score	0.935

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.937	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.937	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q15345

Interaction Score

P14866

(UniProtKB/Swiss-Prot/P) Details

Heterogeneous nuclear ribonucleoprotein L

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Ribonucleoprotein complex (GO:0030529)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Ribonucleoprotein granule (GO:0035770)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q15345

Interaction Score

P22087

(UniProtKB/Swiss-Prot/P) Details

rRNA 2'-O-methyltransferase fibrillarin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Box C/D snoRNP complex (GO:0031428)	0.937	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Small-subunit processome (GO:0032040)	0.937	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Granular component (GO:0001652)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Dense fibrillar component (GO:0001651)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Cajal body (GO:0015030)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.937	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q15345

Interaction Score

Q15562

(UniProtKB/Swiss-Prot/P) Details

Transcriptional enhancer factor TEF-4

Q15345

Interaction Score

Q14258

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin/ISG15 ligase TRIM25

Q15345

Interaction Score

Q01860

(UniProtKB/Swiss-Prot/P) Details

POU domain, class 5, transcription factor 1

Q15345

Interaction Score

Q9UBU9

(UniProtKB/Swiss-Prot/P) Details

Nuclear RNA export factor 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear inclusion body (GO:0042405)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcription export complex (GO:0000346)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q15345

Interaction Score

0.999

Q99728

(UniProtKB/Swiss-Prot/P) Details

BRCA1-associated RING domain protein 1

Q15345

Interaction Score

0.999

Q9Y295

(UniProtKB/Swiss-Prot/P) Details

Developmentally-regulated GTP-binding protein 1

Q15345

Interaction Score

0.999

Q15370

(UniProtKB/Swiss-Prot/P) Details

Elongin-B

Q15345

Interaction Score

0.997

Q93062

(UniProtKB/Swiss-Prot/P) Details

RNA-binding protein with multiple splicing

Q15345

Interaction Score

0.997

Q96GG9

(UniProtKB/Swiss-Prot/P) Details

DCN1-like protein 1

Q15345

Interaction Score

0.996

P19447

(UniProtKB/Swiss-Prot/P) Details

General transcription and DNA repair factor IIH helicase subunit XPB

Q15345

Interaction Score

0.996

Q15369

(UniProtKB/Swiss-Prot/P) Details

Elongin-C

Q15345

Interaction Score

0.994

Q13459

(UniProtKB/Swiss-Prot/P) Details

Unconventional myosin-IXb

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Myosin complex (GO:0016459)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Actin filament (GO:0005884)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q15345

Interaction Score

0.992

O76011

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha4

Q15345

Interaction Score

0.988

Q9UKF6

(UniProtKB/Swiss-Prot/P) Details

Cleavage and polyadenylation specificity factor subunit 3

Q15345

Interaction Score

0.988

P04629

(UniProtKB/Swiss-Prot/P) Details

High affinity nerve growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.7	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.994	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.897	Predicted: pTarget method	LOCATE	PubMed
Membrane	Dendrite (GO:0030425)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q15345

Interaction Score

0.984

Q59E96

(UniProtKB/TrEmbl/P) Details

Nuclear RNA export factor 1 variant

Q15345

Interaction Score

0.982

Q15323

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha1

Q15345

Interaction Score

0.982

Q8IYI6

(UniProtKB/Swiss-Prot/P) Details

Exocyst complex component 8

Q15345

Interaction Score

0.982

Q8IV45

(UniProtKB/Swiss-Prot/P) Details

UNC5C-like protein

Q15345

Interaction Score

0.98

Q93034

(UniProtKB/Swiss-Prot/P) Details

Cullin-5

Q15345

Interaction Score

0.976

Q8WVD2

(UniProtKB/TrEmbl/P) Details

MYO9B protein

Q15345

Interaction Score

0.971

P57078

(UniProtKB/Swiss-Prot/P) Details

Receptor-interacting serine/threonine-protein kinase 4

Q15345

Interaction Score

0.97

A8MQ03

(UniProtKB/Swiss-Prot/P) Details

Cysteine-rich tail protein 1

Q15345

Interaction Score

0.949

F2Z381

(UniProtKB/TrEmbl/P) Details

POU class 5 homeobox 1 transcript variant 6

Q15345

Interaction Score

0.949

B4E3T4

(UniProtKB/TrEmbl/P) Details

HCG2043421, isoform CRA_c

Q15345

Interaction Score

0.949

M1S623

(UniProtKB/TrEmbl/P) Details

POU domain protein

Q15345

Interaction Score

0.949

C9JVE2

(UniProtKB/TrEmbl/P) Details

DCN1-like protein

Q15345

Interaction Score

0.935

P48454

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

Q15345

Interaction Score

0.907

A0AVN2

(UniProtKB/TrEmbl/P) Details

BRCA1 associated RING domain 1

Q15345

Interaction Score

0.857

Q5TD97

(UniProtKB/Swiss-Prot/P) Details

Four and a half LIM domains protein 5

Q15345

Interaction Score

0.856

Q8WWY8

(UniProtKB/Swiss-Prot/P) Details

Lipase member H

Q15345

Interaction Score

0.797

F6MDI1

(UniProtKB/TrEmbl/P) Details

BRCA1 associated RING domain 1 isoform delta

Q15345

Interaction Score

0.797

A0A087WZ19

(UniProtKB/TrEmbl/P) Details

BRCA1-associated RING domain protein 1

Q15345

Interaction Score

0.797

A0A087X2H0

(UniProtKB/TrEmbl/P) Details

BRCA1-associated RING domain protein 1

Q15345

Interaction Score

0.77

Q3LI66

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 6-2

Q15345

Interaction Score

0.77

Q9BYR8

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 3-1

Q15345

Interaction Score

0.697

Q6NTA2

(UniProtKB/TrEmbl/P) Details

HNRNPL protein

Q15345

Interaction Score

0.64

X5DR71

(UniProtKB/TrEmbl/P) Details

Tyrosine-protein kinase receptor

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Q15345

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q15345

P14866

Heterogeneous nuclear ribonucleoprotein L

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

P22087

rRNA 2'-O-methyltransferase fibrillarin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q15562

Transcriptional enhancer factor TEF-4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q14258

E3 ubiquitin/ISG15 ligase TRIM25

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q01860

POU domain, class 5, transcription factor 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q9UBU9

Nuclear RNA export factor 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q99728

BRCA1-associated RING domain protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q9Y295

Developmentally-regulated GTP-binding protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q15370

Elongin-B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q93062

RNA-binding protein with multiple splicing

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

Q96GG9

DCN1-like protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345

P19447

General transcription and DNA repair factor IIH helicase subunit XPB

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15345