Q15475

Homeobox protein SIX1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	34 / 43
Average Interaction Score	0.802

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q15475

Interaction Score

P12755

(UniProtKB/Swiss-Prot/P) Details

Ski oncogene

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	PML body (GO:0016605)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcriptional repressor complex (GO:0017053)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.94	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q15475

Interaction Score

Q9UM11

(UniProtKB/Swiss-Prot/P) Details

Fizzy-related protein homolog

Q15475

Interaction Score

Q99502

(UniProtKB/Swiss-Prot/P) Details

Eyes absent homolog 1

Q15475

Interaction Score

Q04724

(UniProtKB/Swiss-Prot/P) Details

Transducin-like enhancer protein 1

Q15475

Interaction Score

P58012

(UniProtKB/Swiss-Prot/P) Details

Forkhead box protein L2

Q15475

Interaction Score

Q9UI36

(UniProtKB/Swiss-Prot/P) Details

Dachshund homolog 1

Q15475

Interaction Score

Q99504

(UniProtKB/Swiss-Prot/P) Details

Eyes absent homolog 3

Q15475

Interaction Score

0.999

Q08117

(UniProtKB/Swiss-Prot/P) Details

Amino-terminal enhancer of split

Q15475

Interaction Score

0.999

O00358

(UniProtKB/Swiss-Prot/P) Details

Forkhead box protein E1

Q15475

Interaction Score

0.997

O95677

(UniProtKB/Swiss-Prot/P) Details

Eyes absent homolog 4

Q15475

Interaction Score

0.996

P78424

(UniProtKB/Swiss-Prot/P) Details

POU domain, class 6, transcription factor 2

Q15475

Interaction Score

0.994

F8WB53

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.991

Q2NKX8

(UniProtKB/Swiss-Prot/P) Details

DNA excision repair protein ERCC-6-like

Q15475

Interaction Score

0.988

A6NCB9

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.987

O00167

(UniProtKB/Swiss-Prot/P) Details

Eyes absent homolog 2

Q15475

Interaction Score

0.96

A0A2R8YGM9

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.96

A0A2R8Y6K4

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.957

Q99750

(UniProtKB/Swiss-Prot/P) Details

MyoD family inhibitor

Q15475

Interaction Score

0.859

Q15834

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 85B

Q15475

Interaction Score

0.848

Q96CJ7

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.848

Q0P517

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.8

E9PLN6

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.8

F2Z2Y1

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.8

Q53ZD3

(UniProtKB/TrEmbl/P) Details

FOXL2

Q15475

Interaction Score

0.8

B1AKB6

(UniProtKB/TrEmbl/P) Details

MyoD family inhibitor

Q15475

Interaction Score

0.772

E7ETN2

(UniProtKB/TrEmbl/P) Details

Eyes absent homolog

Q15475

Interaction Score

0.763

O75409

(UniProtKB/Swiss-Prot/P) Details

Huntingtin-interacting protein M

Q15475

Interaction Score

0.763

Q58EX7

(UniProtKB/Swiss-Prot/P) Details

Puratrophin-1

Q15475

Interaction Score

0.3

P12883

(UniProtKB/Swiss-Prot/P) Details

Myosin-7

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Myofibril (GO:0030016)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Sarcomere (GO:0030017)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Myosin complex (GO:0016459)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Myosin filament (GO:0032982)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Muscle myosin complex (GO:0005859)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Stress fiber (GO:0001725)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q15475

Interaction Score

0.3

Q9Y623

(UniProtKB/Swiss-Prot/P) Details

Myosin-4

Q15475

Interaction Score

0.295

P11055

(UniProtKB/Swiss-Prot/P) Details

Myosin-3

Q15475

Interaction Score

0.292

P04004

(UniProtKB/Swiss-Prot/P) Details

Vitronectin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.996	Experimental: experimental	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Rough endoplasmic reticulum lumen (GO:0048237)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.999	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.999	Experimental: experimental	MatrixDB	PubMed
Extracellular	Basement membrane (GO:0005604)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Alphav-beta3 integrin-vitronectin complex (GO:0071062)	0.86	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q15475

Interaction Score

0.21

Q5GJ67

(UniProtKB/TrEmbl/P) Details

Hypothetical rhabdomyosarcoma antigen MU-RMS-40.3

Q15475

Interaction Score

Q7Z4N8

(UniProtKB/Swiss-Prot/P) Details

Prolyl 4-hydroxylase subunit alpha-3

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Q15475

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q15475

P12755

Ski oncogene

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

Q9UM11

Fizzy-related protein homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

Q99502

Eyes absent homolog 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

Q04724

Transducin-like enhancer protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

P58012

Forkhead box protein L2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

Q9UI36

Dachshund homolog 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

Q99504

Eyes absent homolog 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

Q08117

Amino-terminal enhancer of split

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

O00358

Forkhead box protein E1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

O95677

Eyes absent homolog 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

P78424

POU domain, class 6, transcription factor 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475

F8WB53

Eyes absent homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15475