Q15486

Putative inactive beta-glucuronidase-like protein SMA3 // UniProt Profile

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Species	H. sapiens
Number of Interactions	23 / 23
Average Interaction Score	0.586

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.973	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Lysosome (GO:0005764)	0.973	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.973	Predicted: pTarget method	LOCATE	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q15486

Interaction Score

0.973

P68104

(UniProtKB/Swiss-Prot/P) Details

Elongation factor 1-alpha 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Eukaryotic translation elongation factor 1 complex (GO:0005853)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Cytosol	Cortical actin cytoskeleton (GO:0030864)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.902	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.902	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.902	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.994	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD, IntAct

Interaction Source Publication:

PubMed

Q15486

Interaction Score

0.973

Q15047

(UniProtKB/Swiss-Prot/P) Details

Histone-lysine N-methyltransferase SETDB1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Chromosome (GO:0005694)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

HPRD, IntAct

Interaction Source Publication:

PubMed

Q15486

Interaction Score

0.971

P04637

(UniProtKB/Swiss-Prot/P) Details

Cellular tumor antigen p53

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular (GO:0005622)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.972	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.972	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PML body (GO:0016605)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcription factor TFIID complex (GO:0005669)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Replication fork (GO:0005657)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q15486

Interaction Score

0.971

Q13432

(UniProtKB/Swiss-Prot/P) Details

Protein unc-119 homolog A

Q15486

Interaction Score

0.961

Q13064

(UniProtKB/Swiss-Prot/P) Details

Probable E3 ubiquitin-protein ligase makorin-3

Q15486

Interaction Score

0.955

Q96HA8

(UniProtKB/Swiss-Prot/P) Details

Protein N-terminal glutamine amidohydrolase

Q15486

Interaction Score

0.932

Q96N21

(UniProtKB/Swiss-Prot/P) Details

AP-4 complex accessory subunit Tepsin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.958	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q15486

Interaction Score

0.932

Q92529

(UniProtKB/Swiss-Prot/P) Details

SHC-transforming protein 3

Q15486

Interaction Score

0.932

O43741

(UniProtKB/Swiss-Prot/P) Details

5'-AMP-activated protein kinase subunit beta-2

Q15486

Interaction Score

0.915

P61956

(UniProtKB/Swiss-Prot/P) Details

Small ubiquitin-related modifier 2

Q15486

Interaction Score

0.837

O14770

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein Meis2

Q15486

Interaction Score

0.778

Q53GA5

(UniProtKB/TrEmbl/P) Details

Cellular tumor antigen p53

Q15486

Interaction Score

0.681

Q2TAL8

(UniProtKB/Swiss-Prot/P) Details

Glutamine-rich protein 1

Q15486

Interaction Score

0.681

Q86UY0

(UniProtKB/TrEmbl/P) Details

TXNDC5 protein

Q15486

Interaction Score

0.681

P22607

(UniProtKB/Swiss-Prot/P) Details

Fibroblast growth factor receptor 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

IntAct, HPRD

Interaction Source Publication:

PubMed

Q15486

Interaction Score

0.292

Q15915

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein ZIC 1

Q15486

Interaction Score

O75603

(UniProtKB/Swiss-Prot/P) Details

Chorion-specific transcription factor GCMb

Q15486

Interaction Score

P51687

(UniProtKB/Swiss-Prot/P) Details

Sulfite oxidase, mitochondrial

Q15486

Interaction Score

P49639

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein Hox-A1

Q15486

Interaction Score

O43711

(UniProtKB/Swiss-Prot/P) Details

T-cell leukemia homeobox protein 3

Q15486

Interaction Score

Q8WU58

(UniProtKB/Swiss-Prot/P) Details

Protein FAM222B

Q15486

Interaction Score

O95947

(UniProtKB/Swiss-Prot/P) Details

T-box transcription factor TBX6

Q15486

Interaction Score

O43593

(UniProtKB/Swiss-Prot/P) Details

Lysine-specific demethylase hairless

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Q15486

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q15486

P68104

Elongation factor 1-alpha 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q15047

Histone-lysine N-methyltransferase SETDB1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

P04637

Cellular tumor antigen p53

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q13432

Protein unc-119 homolog A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q13064

Probable E3 ubiquitin-protein ligase makorin-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q96HA8

Protein N-terminal glutamine amidohydrolase

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q96N21

AP-4 complex accessory subunit Tepsin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q92529

SHC-transforming protein 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

O43741

5'-AMP-activated protein kinase subunit beta-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

P61956

Small ubiquitin-related modifier 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

O14770

Homeobox protein Meis2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486

Q53GA5

Cellular tumor antigen p53

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q15486