Q16819

Meprin A subunit alpha // UniProt Profile

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Species	H. sapiens
Number of Interactions	25 / 29
Average Interaction Score	0.82

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.958	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Meprin A complex (GO:0017090)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q16819

Interaction Score

Q16820

(UniProtKB/Swiss-Prot/P) Details

Meprin A subunit beta

Q16819

Interaction Score

P00747

(UniProtKB/Swiss-Prot/P) Details

Plasminogen

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.86	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.51	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Other organism cell membrane (GO:0044218)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.994	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Unknown: traceable author statement	GO	PubMed
Membrane	Extrinsic to external side of plasma membrane (GO:0031232)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.51	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q16819

Interaction Score

0.998

P25391

(UniProtKB/Swiss-Prot/P) Details

Laminin subunit alpha-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Laminin-1 complex (GO:0005606)	1	Predicted: inferred from physical interaction	GO	PubMed
Extracellular	Laminin-3 complex (GO:0005608)	1	Predicted: inferred from physical interaction	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID, HPRD

Interaction Source Publication:

PubMed

Q16819

Interaction Score

0.997

O15230

(UniProtKB/Swiss-Prot/P) Details

Laminin subunit alpha-5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Laminin-10 complex (GO:0043259)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Laminin-11 complex (GO:0043260)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Laminin-5 complex (GO:0005610)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synaptic cleft (GO:0043083)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed

Q16819

Interaction Score

0.995

P02751

(UniProtKB/Swiss-Prot/P) Details

Fibronectin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.971	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.971	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.79	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.971	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Fibrinogen complex (GO:0005577)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	1	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	1	Experimental: experimental	MatrixDB	PubMed
Extracellular	Basement membrane (GO:0005604)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.79	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q16819

Interaction Score

0.995

P30990

(UniProtKB/Swiss-Prot/P) Details

Neurotensin/neuromedin N

Q16819

Interaction Score

0.994

P01042

(UniProtKB/Swiss-Prot/P) Details

Kininogen-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.853	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.853	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.853	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.994	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.994	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD, BioGRID

Interaction Source Publication:

PubMed

Q16819

Interaction Score

0.993

P14780

(UniProtKB/Swiss-Prot/P) Details

Matrix metalloproteinase-9

Q16819

Interaction Score

0.991

P01189

(UniProtKB/Swiss-Prot/P) Details

Pro-opiomelanocortin

Q16819

Interaction Score

0.991

P01275

(UniProtKB/Swiss-Prot/P) Details

Glucagon

Q16819

Interaction Score

0.991

P20366

(UniProtKB/Swiss-Prot/P) Details

Protachykinin-1

Q16819

Interaction Score

0.989

P07492

(UniProtKB/Swiss-Prot/P) Details

Gastrin-releasing peptide

Q16819

Interaction Score

0.989

P01303

(UniProtKB/Swiss-Prot/P) Details

Pro-neuropeptide Y

Q16819

Interaction Score

0.988

P01019

(UniProtKB/Swiss-Prot/P) Details

Angiotensinogen

Q16819

Interaction Score

0.984

P01148

(UniProtKB/Swiss-Prot/P) Details

Progonadoliberin-1

Q16819

Interaction Score

0.981

P01270

(UniProtKB/Swiss-Prot/P) Details

Parathyroid hormone

Q16819

Interaction Score

0.963

P09683

(UniProtKB/Swiss-Prot/P) Details

Secretin

Q16819

Interaction Score

0.956

P01282

(UniProtKB/Swiss-Prot/P) Details

VIP peptides

Q16819

Interaction Score

0.766

B7ZL91

(UniProtKB/TrEmbl/P) Details

Meprin A subunit

Q16819

Interaction Score

0.74

Q6MZF4

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686F219

Q16819

Interaction Score

0.74

Q6MZM7

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686O12165

Q16819

Interaction Score

0.24

Q6FH20

(UniProtKB/TrEmbl/P) Details

NTS protein

Q16819

Interaction Score

0.21

Q9UQ35

(UniProtKB/Swiss-Prot/P) Details

Serine/arginine repetitive matrix protein 2

Q16819

Interaction Score

A4D158

(UniProtKB/TrEmbl/P) Details

Neuropeptide Y

Q16819

Interaction Score

Q6FG82

(UniProtKB/TrEmbl/P) Details

CCK protein

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Q16819

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q16819

Q16820

Meprin A subunit beta

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P00747

Plasminogen

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P25391

Laminin subunit alpha-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

O15230

Laminin subunit alpha-5

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P02751

Fibronectin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P30990

Neurotensin/neuromedin N

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P01042

Kininogen-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P14780

Matrix metalloproteinase-9

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P01189

Pro-opiomelanocortin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P01275

Glucagon

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P20366

Protachykinin-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819

P07492

Gastrin-releasing peptide

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q16819