Q6FGU7

RAB7, member RAS oncogene family-like 1, isoform CRA_a // UniProt Profile

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Species	H. sapiens
Number of Interactions	19 / 31
Average Interaction Score	0.775

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.8	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q6FGU7

Interaction Score

0.959

Q04656

(UniProtKB/Swiss-Prot/P) Details

Copper-transporting ATPase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell leading edge (GO:0031252)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Trans-Golgi network transport vesicle (GO:0030140)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Membrane	Microvillus (GO:0005902)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Brush border membrane (GO:0031526)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.959

Q14643

(UniProtKB/Swiss-Prot/P) Details

Inositol 1,4,5-trisphosphate receptor type 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Calcineurin complex (GO:0005955)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Sarcoplasmic reticulum (GO:0016529)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Platelet dense tubular network (GO:0031094)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Platelet dense tubular network membrane (GO:0031095)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear inner membrane (GO:0005637)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.998	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Platelet dense granule membrane (GO:0031088)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Transport vesicle membrane (GO:0030658)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.994	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.994	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.959

Q14571

(UniProtKB/Swiss-Prot/P) Details

Inositol 1,4,5-trisphosphate receptor type 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.991	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.991	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Sarcoplasmic reticulum membrane (GO:0033017)	0.991	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cell cortex (GO:0005938)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Platelet dense tubular network membrane (GO:0031095)	0.991	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.958

Q14573

(UniProtKB/Swiss-Prot/P) Details

Inositol 1,4,5-trisphosphate receptor type 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.987	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	0.987	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.987	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.987	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Platelet dense tubular network membrane (GO:0031095)	0.987	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear outer membrane (GO:0005640)	0.853	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Brush border (GO:0005903)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.953

Q9NVJ2

(UniProtKB/Swiss-Prot/P) Details

ADP-ribosylation factor-like protein 8B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.958	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.958	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.926

P14373

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein RFP

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Retromer complex (GO:0030904)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PML body (GO:0016605)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.8	Experimental: experimental	Organelle	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.848

Q16827

(UniProtKB/Swiss-Prot/P) Details

Receptor-type tyrosine-protein phosphatase O

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Growth cone (GO:0030426)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Lateral plasma membrane (GO:0016328)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q6FGU7

Interaction Score

0.81

Q92696

(UniProtKB/Swiss-Prot/P) Details

Geranylgeranyl transferase type-2 subunit alpha

Q6FGU7

Interaction Score

0.806

Q59H91

(UniProtKB/TrEmbl/P) Details

Inositol 1,4,5-trisphosphate receptor type 1 variant

Q6FGU7

Interaction Score

0.8

Q96LI5

(UniProtKB/Swiss-Prot/P) Details

CCR4-NOT transcription complex subunit 6-like

Q6FGU7

Interaction Score

0.798

P26374

(UniProtKB/Swiss-Prot/P) Details

Rab proteins geranylgeranyltransferase component A 2

Q6FGU7

Interaction Score

0.798

P24386

(UniProtKB/Swiss-Prot/P) Details

Rab proteins geranylgeranyltransferase component A 1

Q6FGU7

Interaction Score

0.793

Q5VSL9

(UniProtKB/Swiss-Prot/P) Details

Striatin-interacting protein 1

Q6FGU7

Interaction Score

0.75

Q9UK45

(UniProtKB/Swiss-Prot/P) Details

U6 snRNA-associated Sm-like protein LSm7

Q6FGU7

Interaction Score

0.728

Q762B6

(UniProtKB/TrEmbl/P) Details

ATP7A protein

Q6FGU7

Interaction Score

0.688

Q8N7W2

(UniProtKB/Swiss-Prot/P) Details

BEN domain-containing protein 7

Q6FGU7

Interaction Score

0.64

Q9H6J7

(UniProtKB/Swiss-Prot/P) Details

UPF0705 protein C11orf49

Q6FGU7

Interaction Score

0.56

Q59ES2

(UniProtKB/TrEmbl/P) Details

Inositol 1,4,5-trisphosphate receptor type 3 variant

Q6FGU7

Interaction Score

O95751

(UniProtKB/Swiss-Prot/P) Details

Protein LDOC1

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Q6FGU7

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q6FGU7

Q04656

Copper-transporting ATPase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q14643

Inositol 1,4,5-trisphosphate receptor type 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q14571

Inositol 1,4,5-trisphosphate receptor type 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q14573

Inositol 1,4,5-trisphosphate receptor type 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q9NVJ2

ADP-ribosylation factor-like protein 8B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

P14373

Zinc finger protein RFP

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q16827

Receptor-type tyrosine-protein phosphatase O

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q92696

Geranylgeranyl transferase type-2 subunit alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q59H91

Inositol 1,4,5-trisphosphate receptor type 1 variant

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

Q96LI5

CCR4-NOT transcription complex subunit 6-like

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

P26374

Rab proteins geranylgeranyltransferase component A 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7

P24386

Rab proteins geranylgeranyltransferase component A 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q6FGU7