Q8IZZ5

Coagulation factor XII-Mie // UniProt Profile

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Species	H. sapiens
Number of Interactions	19 / 29
Average Interaction Score	0.215

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.7	Predicted: pTarget method	LOCATE	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q8IZZ5

Interaction Score

0.833

P11142

(UniProtKB/Swiss-Prot/P) Details

Heat shock cognate 71 kDa protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Prp19 complex (GO:0000974)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Spliceosomal complex (GO:0005681)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosomal lumen (GO:0043202)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.657	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin sculpted gamma-aminobutyric acid transport vesicle membrane (GO:0061202)	0.657	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.986	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.986	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.986	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.986	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.986	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.931	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.931	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.931	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.931	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8IZZ5

Interaction Score

0.832

P00748

(UniProtKB/Swiss-Prot/P) Details

Coagulation factor XII

Q8IZZ5

Interaction Score

0.658

P07359

(UniProtKB/Swiss-Prot/P) Details

Platelet glycoprotein Ib alpha chain

Q8IZZ5

Interaction Score

0.652

P61077

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D3

Q8IZZ5

Interaction Score

0.56

Q6AI12

(UniProtKB/Swiss-Prot/P) Details

Ankyrin repeat domain-containing protein 40

Q8IZZ5

Interaction Score

0.553

Q9C0C7

(UniProtKB/Swiss-Prot/P) Details

Activating molecule in BECN1-regulated autophagy protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.972	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	0.972	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Axoneme (GO:0005930)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8IZZ5

Interaction Score

P51668

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D1

Q8IZZ5

Interaction Score

P61088

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 N

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	UBC13-MMS2 complex (GO:0031372)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	UBC13-UEV1A complex (GO:0035370)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8IZZ5

Interaction Score

P51965

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 E1

Q8IZZ5

Interaction Score

B7Z306

(UniProtKB/TrEmbl/P) Details

cDNA FLJ52264, highly similar to Ubiquitin-conjugating enzyme E2 E1

Q8IZZ5

Interaction Score

D6RAH7

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 D3

Q8IZZ5

Interaction Score

P62837

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin-conjugating enzyme E2 D2

Q8IZZ5

Interaction Score

A0A087WW00

(UniProtKB/TrEmbl/P) Details

Ubiquitin-conjugating enzyme E2 D1

Q8IZZ5

Interaction Score

O15091

(UniProtKB/Swiss-Prot/P) Details

Mitochondrial ribonuclease P catalytic subunit

Q8IZZ5

Interaction Score

Q96RS6

(UniProtKB/Swiss-Prot/P) Details

NudC domain-containing protein 1

Q8IZZ5

Interaction Score

A0A075B6T1

(UniProtKB/TrEmbl/P) Details

Activating molecule in BECN1-regulated autophagy protein 1

Q8IZZ5

Interaction Score

Q8NG27

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase Praja-1

Q8IZZ5

Interaction Score

Q16665

(UniProtKB/Swiss-Prot/P) Details

Hypoxia-inducible factor 1-alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Predicted: inferred from physical interaction	GO	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Membrane	Motile cilium (GO:0031514)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8IZZ5

Interaction Score

Q99814

(UniProtKB/Swiss-Prot/P) Details

Endothelial PAS domain-containing protein 1

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Q8IZZ5

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8IZZ5

P11142

Heat shock cognate 71 kDa protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P00748

Coagulation factor XII

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P07359

Platelet glycoprotein Ib alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P61077

Ubiquitin-conjugating enzyme E2 D3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

Q6AI12

Ankyrin repeat domain-containing protein 40

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

Q9C0C7

Activating molecule in BECN1-regulated autophagy protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P51668

Ubiquitin-conjugating enzyme E2 D1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P61088

Ubiquitin-conjugating enzyme E2 N

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P51965

Ubiquitin-conjugating enzyme E2 E1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

B7Z306

cDNA FLJ52264, highly similar to Ubiquitin-conjugating enzyme E2 E1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

D6RAH7

Ubiquitin-conjugating enzyme E2 D3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5

P62837

Ubiquitin-conjugating enzyme E2 D2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8IZZ5