Q8NAT1

Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 // UniProt Profile

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Species	H. sapiens
Number of Interactions	37 / 57
Average Interaction Score	0.507

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.958	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.958	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q8NAT1

Interaction Score

0.994

P05067

(UniProtKB/Swiss-Prot/P) Details

Amyloid-beta A4 protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Coated pit (GO:0005905)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Apical part of cell (GO:0045177)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	eSLDB	PubMed
Nucleus	Nuclear envelope lumen (GO:0005641)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Smooth endoplasmic reticulum (GO:0005790)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome lumen (GO:0031904)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle (GO:0030134)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Astrocyte projection (GO:0097449)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Main axon (GO:0044304)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ciliary rootlet (GO:0035253)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.98	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.98	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic active zone (GO:0048786)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NAT1

Interaction Score

0.989

Q92581

(UniProtKB/Swiss-Prot/P) Details

Sodium/hydrogen exchanger 6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.992	Experimental: experimental	Organelle	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Experimental: experimental	Organelle	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Nerve terminal (GO:0043679)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NAT1

Interaction Score

0.983

Q13635

(UniProtKB/Swiss-Prot/P) Details

Protein patched homolog 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endocytic vesicle membrane (GO:0030666)	0.972	Unknown: traceable author statement	GO	PubMed
Membrane	Dendritic growth cone (GO:0044294)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axonal growth cone (GO:0044295)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cilium membrane (GO:0060170)	1	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Caveola (GO:0005901)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NAT1

Interaction Score

0.978

Q03405

(UniProtKB/Swiss-Prot/P) Details

Urokinase plasminogen activator surface receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.902	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.902	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.902	Unknown: traceable author statement	GO	PubMed
Membrane	Invadopodium membrane (GO:0071438)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Extrinsic to membrane (GO:0019898)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Anchored to membrane (GO:0031225)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NAT1

Interaction Score

0.965

Q02297

(UniProtKB/Swiss-Prot/P) Details

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Cell body (GO:0044297)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axolemma (GO:0030673)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.987	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Experimental: experimental	MatrixDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.976	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NAT1

Interaction Score

0.95

Q9NWM8

(UniProtKB/Swiss-Prot/P) Details

Peptidyl-prolyl cis-trans isomerase FKBP14

Q8NAT1

Interaction Score

0.939

P54709

(UniProtKB/Swiss-Prot/P) Details

Sodium/potassium-transporting ATPase subunit beta-3

Q8NAT1

Interaction Score

0.927

Q15165

(UniProtKB/Swiss-Prot/P) Details

Serum paraoxonase/arylesterase 2

Q8NAT1

Interaction Score

0.91

Q13296

(UniProtKB/Swiss-Prot/P) Details

Mammaglobin-A

Q8NAT1

Interaction Score

0.908

Q7Z3S9

(UniProtKB/Swiss-Prot/P) Details

Notch homolog 2 N-terminal-like protein

Q8NAT1

Interaction Score

0.865

Q96LR4

(UniProtKB/Swiss-Prot/P) Details

Protein FAM19A4

Q8NAT1

Interaction Score

0.815

A0A0A0MRG2

(UniProtKB/TrEmbl/P) Details

Amyloid-beta A4 protein

Q8NAT1

Interaction Score

0.768

P58012

(UniProtKB/Swiss-Prot/P) Details

Forkhead box protein L2

Q8NAT1

Interaction Score

0.766

E9PG40

(UniProtKB/TrEmbl/P) Details

Amyloid-beta A4 protein

Q8NAT1

Interaction Score

0.766

B4DGD7

(UniProtKB/TrEmbl/P) Details

cDNA FLJ53595, highly similar to Iduronate 2-sulfatase

Q8NAT1

Interaction Score

0.748

Q9UGM1

(UniProtKB/Swiss-Prot/P) Details

Neuronal acetylcholine receptor subunit alpha-9

Q8NAT1

Interaction Score

0.732

Q9NQX5

(UniProtKB/Swiss-Prot/P) Details

Neural proliferation differentiation and control protein 1

Q8NAT1

Interaction Score

0.671

P22304

(UniProtKB/Swiss-Prot/P) Details

Iduronate 2-sulfatase

Q8NAT1

Interaction Score

0.64

A0A1B0GV11

(UniProtKB/TrEmbl/P) Details

Sodium/hydrogen exchanger

Q8NAT1

Interaction Score

0.56

Q6NX70

(UniProtKB/TrEmbl/P) Details

Mammaglobin-A

Q8NAT1

Interaction Score

0.56

Q6PK61

(UniProtKB/TrEmbl/P) Details

Neuregulin 1

Q8NAT1

Interaction Score

0.56

Q7RTW5

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-gamma

Q8NAT1

Interaction Score

0.287

Q9NRD1

(UniProtKB/Swiss-Prot/P) Details

F-box only protein 6

Q8NAT1

Interaction Score

0.24

Q9ULX3

(UniProtKB/Swiss-Prot/P) Details

RNA-binding protein NOB1

Q8NAT1

Interaction Score

0.24

M0R1I2

(UniProtKB/TrEmbl/P) Details

Urokinase plasminogen activator surface receptor

Q8NAT1

Interaction Score

O60573

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic translation initiation factor 4E type 2

Q8NAT1

Interaction Score

Q9BY49

(UniProtKB/Swiss-Prot/P) Details

Peroxisomal trans-2-enoyl-CoA reductase

Q8NAT1

Interaction Score

Q53ZD3

(UniProtKB/TrEmbl/P) Details

FOXL2

Q8NAT1

Interaction Score

B8ZZ50

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E type 2

Q8NAT1

Interaction Score

B8ZZL3

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E type 2

Q8NAT1

Interaction Score

Q96G27

(UniProtKB/Swiss-Prot/P) Details

WW domain-binding protein 1

Q8NAT1

Interaction Score

B9A023

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E type 2

Q8NAT1

Interaction Score

Q53RG0

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E member 2, isoform CRA_c

Q8NAT1

Interaction Score

Q59FE1

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E member 2 variant

Q8NAT1

Interaction Score

Q7RTW3

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-beta2

Q8NAT1

Interaction Score

Q14258

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin/ISG15 ligase TRIM25

Q8NAT1

Interaction Score

F6RJN6

(UniProtKB/TrEmbl/P) Details

Pro-neuregulin-1, membrane-bound isoform

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Q8NAT1

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8NAT1

P05067

Amyloid-beta A4 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q92581

Sodium/hydrogen exchanger 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q13635

Protein patched homolog 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q03405

Urokinase plasminogen activator surface receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q02297

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q9NWM8

Peptidyl-prolyl cis-trans isomerase FKBP14

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

P54709

Sodium/potassium-transporting ATPase subunit beta-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q15165

Serum paraoxonase/arylesterase 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q13296

Mammaglobin-A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q7Z3S9

Notch homolog 2 N-terminal-like protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

Q96LR4

Protein FAM19A4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1

A0A0A0MRG2

Amyloid-beta A4 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NAT1