Q8NCM8

Cytoplasmic dynein 2 heavy chain 1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	22 / 32
Average Interaction Score	0.925

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic dynein complex (GO:0005868)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule (GO:0005874)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Axoneme (GO:0005930)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Cilium (GO:0005929)	0.853	Unknown: traceable author statement	GO	PubMed
Membrane	Motile cilium (GO:0031514)	0.853	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q8NCM8

Interaction Score

O75381

(UniProtKB/Swiss-Prot/P) Details

Peroxisomal membrane protein PEX14

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Peroxisome (GO:0005777)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Peroxisome (GO:0005777)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Peroxisome (GO:0005777)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Peroxisome (GO:0005777)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Peroxisome (GO:0005777)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Peroxisomal membrane (GO:0005778)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Peroxisomal membrane (GO:0005778)	1	Experimental: experimental	Organelle	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.958	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q8NCM8

Interaction Score

Q9Y230

(UniProtKB/Swiss-Prot/P) Details

RuvB-like 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	R2TP complex (GO:0097255)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	MLL1 complex (GO:0071339)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	NuA4 histone acetyltransferase complex (GO:0035267)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear euchromatin (GO:0005719)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Ino80 complex (GO:0031011)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Swr1 complex (GO:0000812)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NCM8

Interaction Score

Q8TCX1

(UniProtKB/Swiss-Prot/P) Details

Cytoplasmic dynein 2 light intermediate chain 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Apical part of cell (GO:0045177)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytoplasmic dynein complex (GO:0005868)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cilium basal body (GO:0036064)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic microtubule (GO:0005881)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Axoneme (GO:0005930)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intraflagellar transport particle (GO:0030990)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cilium (GO:0005929)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Ciliary transition zone (GO:0035869)	0.982	Experimental: inferred from direct assay	GO	PubMed
Membrane	Motile cilium (GO:0031514)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NCM8

Interaction Score

P31150

(UniProtKB/Swiss-Prot/P) Details

Rab GDP dissociation inhibitor alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.902	Experimental: inferred from direct assay	GO	PubMed
Membrane	Myelin sheath (GO:0043209)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8NCM8

Interaction Score

Q9H2C0

(UniProtKB/Swiss-Prot/P) Details

Gigaxonin

Q8NCM8

Interaction Score

0.999

Q969Q6

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Q8NCM8

Interaction Score

0.999

P42331

(UniProtKB/Swiss-Prot/P) Details

Rho GTPase-activating protein 25

Q8NCM8

Interaction Score

0.995

Q9Y2S2

(UniProtKB/Swiss-Prot/P) Details

Lambda-crystallin homolog

Q8NCM8

Interaction Score

0.993

Q96F46

(UniProtKB/Swiss-Prot/P) Details

Interleukin-17 receptor A

Q8NCM8

Interaction Score

0.988

Q17RP2

(UniProtKB/Swiss-Prot/P) Details

Tigger transposable element-derived protein 6

Q8NCM8

Interaction Score

0.982

O95396

(UniProtKB/Swiss-Prot/P) Details

Adenylyltransferase and sulfurtransferase MOCS3

Q8NCM8

Interaction Score

0.955

P55899

(UniProtKB/Swiss-Prot/P) Details

IgG receptor FcRn large subunit p51

Q8NCM8

Interaction Score

0.947

P49286

(UniProtKB/Swiss-Prot/P) Details

Melatonin receptor type 1B

Q8NCM8

Interaction Score

0.946

P21709

(UniProtKB/Swiss-Prot/P) Details

Ephrin type-A receptor 1

Q8NCM8

Interaction Score

0.94

Q86V87

(UniProtKB/Swiss-Prot/P) Details

Protein FAM160B2

Q8NCM8

Interaction Score

0.937

Q8NBT2

(UniProtKB/Swiss-Prot/P) Details

Kinetochore protein Spc24

Q8NCM8

Interaction Score

0.931

Q5TF39

(UniProtKB/Swiss-Prot/P) Details

Sodium-dependent glucose transporter 1

Q8NCM8

Interaction Score

0.912

Q6ZW49

(UniProtKB/Swiss-Prot/P) Details

PAX-interacting protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Histone methyltransferase complex (GO:0035097)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	MLL3/4 complex (GO:0044666)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NCM8

Interaction Score

0.91

Q70EL3

(UniProtKB/Swiss-Prot/P) Details

Inactive ubiquitin carboxyl-terminal hydrolase 50

Q8NCM8

Interaction Score

0.886

A0A2R8Y4K2

(UniProtKB/TrEmbl/P) Details

Crystallin, lambda 1, isoform CRA_c

Q8NCM8

Interaction Score

0.732

Q15233

(UniProtKB/Swiss-Prot/P) Details

Non-POU domain-containing octamer-binding protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Paraspeckles (GO:0042382)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	RNA polymerase II transcription factor complex (GO:0090575)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8NCM8

Interaction Score

0.3

P05412

(UniProtKB/Swiss-Prot/P) Details

Transcription factor AP-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcriptional repressor complex (GO:0017053)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	AP1 complex (GO:0035976)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear chromosome (GO:0000228)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear euchromatin (GO:0005719)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

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Q8NCM8

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8NCM8

O75381

Peroxisomal membrane protein PEX14

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q9Y230

RuvB-like 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q8TCX1

Cytoplasmic dynein 2 light intermediate chain 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

P31150

Rab GDP dissociation inhibitor alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q9H2C0

Gigaxonin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q969Q6

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

P42331

Rho GTPase-activating protein 25

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q9Y2S2

Lambda-crystallin homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q96F46

Interleukin-17 receptor A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

Q17RP2

Tigger transposable element-derived protein 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

O95396

Adenylyltransferase and sulfurtransferase MOCS3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8

P55899

IgG receptor FcRn large subunit p51

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8NCM8