Q8TAB5

UPF0500 protein C1orf216 // UniProt Profile

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Species	H. sapiens
Number of Interactions	77 / 95
Average Interaction Score	0.885

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.995	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q8TAB5

Interaction Score

0.999

P37198

(UniProtKB/Swiss-Prot/P) Details

Nuclear pore glycoprotein p62

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Flemming body (GO:0090543)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: non-traceable author statement	GO	PubMed
Mitochondrion	Pore complex (GO:0046930)	0.8	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nuclear pore central transport channel (GO:0044613)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.86	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Mitotic spindle (GO:0072686)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Annulate lamellae (GO:0005642)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.999

Q16637

(UniProtKB/Swiss-Prot/P) Details

Survival motor neuron protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Perikaryon (GO:0043204)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	SMN-Sm protein complex (GO:0034719)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	SMN complex (GO:0032797)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Gemini of coiled bodies (GO:0097504)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Cajal body (GO:0015030)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.999

Q9NPF5

(UniProtKB/Swiss-Prot/P) Details

DNA methyltransferase 1-associated protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	NuA4 histone acetyltransferase complex (GO:0035267)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Replication fork (GO:0005657)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.999

P62333

(UniProtKB/Swiss-Prot/P) Details

26S proteasome regulatory subunit 10B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Proteasome complex (GO:0000502)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosolic proteasome complex (GO:0031597)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Proteasome accessory complex (GO:0022624)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Proteasome regulatory particle, base subcomplex (GO:0008540)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear proteasome complex (GO:0031595)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.999

Q4VCS5

(UniProtKB/Swiss-Prot/P) Details

Angiomotin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Signalosome (GO:0008180)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle (GO:0030139)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.992	Experimental: experimental	eSLDB	PubMed
Cytosol	Actin filament (GO:0005884)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle (GO:0001726)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Tight junction (GO:0005923)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

CCSB, BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.999

Q9UJY5

(UniProtKB/Swiss-Prot/P) Details

ADP-ribosylation factor-binding protein GGA1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.999	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.902	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	0.902	Unknown: HDA	GO	PubMed
Membrane	Clathrin adaptor complex (GO:0030131)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.998

Q9NVV9

(UniProtKB/Swiss-Prot/P) Details

THAP domain-containing protein 1

Q8TAB5

Interaction Score

0.998

Q9NYP9

(UniProtKB/Swiss-Prot/P) Details

Protein Mis18-alpha

Q8TAB5

Interaction Score

0.998

Q9H3R5

(UniProtKB/Swiss-Prot/P) Details

Centromere protein H

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.79	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Kinetochore (GO:0000776)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.997

Q96F24

(UniProtKB/Swiss-Prot/P) Details

Nuclear receptor-binding factor 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Phosphatidylinositol 3-kinase complex, class III (GO:0035032)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.997

Q96KN3

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein PKNOX2

Q8TAB5

Interaction Score

0.997

Q13287

(UniProtKB/Swiss-Prot/P) Details

N-myc-interactor

Q8TAB5

Interaction Score

0.995

Q9NPJ6

(UniProtKB/Swiss-Prot/P) Details

Mediator of RNA polymerase II transcription subunit 4

Q8TAB5

Interaction Score

0.994

Q9UJW9

(UniProtKB/Swiss-Prot/P) Details

SERTA domain-containing protein 3

Q8TAB5

Interaction Score

0.994

Q08117

(UniProtKB/Swiss-Prot/P) Details

Amino-terminal enhancer of split

Q8TAB5

Interaction Score

0.994

Q96JN2

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 136

Q8TAB5

Interaction Score

0.993

Q9BT25

(UniProtKB/Swiss-Prot/P) Details

HAUS augmin-like complex subunit 8

Q8TAB5

Interaction Score

0.991

Q8NFW9

(UniProtKB/Swiss-Prot/P) Details

Rab effector MyRIP

Q8TAB5

Interaction Score

0.989

Q01850

(UniProtKB/Swiss-Prot/P) Details

Cerebellar degeneration-related protein 2

Q8TAB5

Interaction Score

0.987

Q5JR59

(UniProtKB/Swiss-Prot/P) Details

Microtubule-associated tumor suppressor candidate 2

Q8TAB5

Interaction Score

0.987

Q15311

(UniProtKB/Swiss-Prot/P) Details

RalA-binding protein 1

Q8TAB5

Interaction Score

0.985

Q99750

(UniProtKB/Swiss-Prot/P) Details

MyoD family inhibitor

Q8TAB5

Interaction Score

0.981

Q96M63

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 114

Q8TAB5

Interaction Score

0.98

Q6ZMU5

(UniProtKB/Swiss-Prot/P) Details

Tripartite motif-containing protein 72

Q8TAB5

Interaction Score

0.98

Q86X02

(UniProtKB/Swiss-Prot/P) Details

Cerebellar degeneration-related protein 2-like

Q8TAB5

Interaction Score

0.979

Q13077

(UniProtKB/Swiss-Prot/P) Details

TNF receptor-associated factor 1

Q8TAB5

Interaction Score

0.976

A2BDD9

(UniProtKB/TrEmbl/P) Details

AMOT protein

Q8TAB5

Interaction Score

0.974

Q5M9N0

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 158

Q8TAB5

Interaction Score

0.971

Q9BV99

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat-containing protein 61

Q8TAB5

Interaction Score

0.971

P08779

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 16

Q8TAB5

Interaction Score

0.971

P19012

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 15

Q8TAB5

Interaction Score

0.959

P06753

(UniProtKB/Swiss-Prot/P) Details

Tropomyosin alpha-3 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Muscle thin filament tropomyosin (GO:0005862)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Actin filament (GO:0005884)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Stress fiber (GO:0001725)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q8TAB5

Interaction Score

0.959

O76011

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha4

Q8TAB5

Interaction Score

0.958

Q8N6Y0

(UniProtKB/Swiss-Prot/P) Details

Usher syndrome type-1C protein-binding protein 1

Q8TAB5

Interaction Score

0.957

O15513

(UniProtKB/TrEmbl/P) Details

Alpha-tropomyosin

Q8TAB5

Interaction Score

0.956

P54257

(UniProtKB/Swiss-Prot/P) Details

Huntingtin-associated protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Inclusion body (GO:0016234)	0.995	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.995	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.995	Experimental: experimental	Organelle	PubMed
Cytosol	Centrosome (GO:0005813)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Centriole (GO:0005814)	0.995	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.995	Unknown: traceable author statement	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.939

P09493

(UniProtKB/Swiss-Prot/P) Details

Tropomyosin alpha-1 chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Sarcomere (GO:0030017)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Muscle thin filament tropomyosin (GO:0005862)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Actin filament (GO:0005884)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Stress fiber (GO:0001725)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Bleb (GO:0032059)	0.96	Experimental: inferred from mutant phenotype	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.939

P17661

(UniProtKB/Swiss-Prot/P) Details

Desmin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intermediate filament (GO:0005882)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Sarcolemma (GO:0042383)	0.98	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Fascia adherens (GO:0005916)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Intercalated disc (GO:0014704)	0.98	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.98	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.939

Q96GS4

(UniProtKB/Swiss-Prot/P) Details

BLOC-1-related complex subunit 6

Q8TAB5

Interaction Score

0.938

Q9BYV2

(UniProtKB/Swiss-Prot/P) Details

Tripartite motif-containing protein 54

Q8TAB5

Interaction Score

0.935

A1L4K1

(UniProtKB/Swiss-Prot/P) Details

Fibronectin type III and SPRY domain-containing protein 2

Q8TAB5

Interaction Score

0.926

A0A087X2I1

(UniProtKB/TrEmbl/P) Details

26S proteasome regulatory subunit 10B

Q8TAB5

Interaction Score

0.905

Q8N1B4

(UniProtKB/Swiss-Prot/P) Details

Vacuolar protein sorting-associated protein 52 homolog

Q8TAB5

Interaction Score

0.905

Q96L14

(UniProtKB/Swiss-Prot/P) Details

Cep170-like protein

Q8TAB5

Interaction Score

0.866

Q8NCU1

(UniProtKB/Swiss-Prot/P) Details

Uncharacterized protein CCDC197

Q8TAB5

Interaction Score

0.866

Q8N8Y1

(UniProtKB/TrEmbl/P) Details

Usher syndrome 1C binding protein 1, isoform CRA_a

Q8TAB5

Interaction Score

0.86

P13646

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 13

Q8TAB5

Interaction Score

0.859

Q13155

(UniProtKB/Swiss-Prot/P) Details

Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Q8TAB5

Interaction Score

0.857

Q01546

(UniProtKB/Swiss-Prot/P) Details

Keratin, type II cytoskeletal 2 oral

Q8TAB5

Interaction Score

0.852

O00303

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic translation initiation factor 3 subunit F

Q8TAB5

Interaction Score

0.8

Q53EZ4

(UniProtKB/Swiss-Prot/P) Details

Centrosomal protein of 55 kDa

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Midbody (GO:0030496)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Flemming body (GO:0090543)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cleavage furrow (GO:0032154)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centriole (GO:0005814)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.799

Q15323

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha1

Q8TAB5

Interaction Score

0.799

O95678

(UniProtKB/Swiss-Prot/P) Details

Keratin, type II cytoskeletal 75

Q8TAB5

Interaction Score

0.799

Q8IUH5

(UniProtKB/Swiss-Prot/P) Details

Palmitoyltransferase ZDHHC17

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Aggresome (GO:0016235)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Aggresome (GO:0016235)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi-associated vesicle membrane (GO:0030660)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.897	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic membrane (GO:0042734)	0.897	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TAB5

Interaction Score

0.797

Q6ZN40

(UniProtKB/TrEmbl/P) Details

Tropomyosin 1 (Alpha), isoform CRA_f

Q8TAB5

Interaction Score

0.797

Q2M2I5

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 24

Q8TAB5

Interaction Score

0.796

H7C4R2

(UniProtKB/TrEmbl/P) Details

Coiled-coil domain-containing protein 136

Q8TAB5

Interaction Score

0.795

O76015

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha8

Q8TAB5

Interaction Score

0.795

Q14525

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha3-II

Q8TAB5

Interaction Score

0.79

F5H7S3

(UniProtKB/TrEmbl/P) Details

Tropomyosin alpha-1 chain

Q8TAB5

Interaction Score

0.789

O00471

(UniProtKB/Swiss-Prot/P) Details

Exocyst complex component 5

Q8TAB5

Interaction Score

0.775

Q7Z3Y8

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 27

Q8TAB5

Interaction Score

0.768

B7Z596

(UniProtKB/TrEmbl/P) Details

Tropomyosin alpha-1 chain

Q8TAB5

Interaction Score

0.768

H0YK48

(UniProtKB/TrEmbl/P) Details

Tropomyosin alpha-1 chain

Q8TAB5

Interaction Score

0.768

H7BYY1

(UniProtKB/TrEmbl/P) Details

Tropomyosin 1 (Alpha), isoform CRA_m

Q8TAB5

Interaction Score

0.768

A0A087WWU8

(UniProtKB/TrEmbl/P) Details

Tropomyosin alpha-3 chain

Q8TAB5

Interaction Score

0.766

Q96RQ9

(UniProtKB/Swiss-Prot/P) Details

L-amino-acid oxidase

Q8TAB5

Interaction Score

0.765

Q6A162

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 40

Q8TAB5

Interaction Score

0.765

Q6A163

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 39

Q8TAB5

Interaction Score

0.728

Q8N6Q1

(UniProtKB/Swiss-Prot/P) Details

Transmembrane and coiled-coil domain-containing protein 5A

Q8TAB5

Interaction Score

0.728

Q1A5X7

(UniProtKB/Swiss-Prot/P) Details

Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

Q8TAB5

Interaction Score

0.696

Q96I34

(UniProtKB/Swiss-Prot/P) Details

Protein phosphatase 1 regulatory subunit 16A

Q8TAB5

Interaction Score

0.696

Q9NRP2

(UniProtKB/Swiss-Prot/P) Details

COX assembly mitochondrial protein 2 homolog

Q8TAB5

Interaction Score

0.64

J3KQA9

(UniProtKB/TrEmbl/P) Details

Microtubule-associated tumor suppressor candidate 2

Q8TAB5

Interaction Score

0.56

A1A4E9

(UniProtKB/TrEmbl/P) Details

Keratin 13, isoform CRA_a

Q8TAB5

Interaction Score

0.56

P43360

(UniProtKB/Swiss-Prot/P) Details

Melanoma-associated antigen 6

Q8TAB5

Interaction Score

0.56

Q96HT8

(UniProtKB/Swiss-Prot/P) Details

MORF4 family-associated protein 1-like 1

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Q8TAB5

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8TAB5

P37198

Nuclear pore glycoprotein p62

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q16637

Survival motor neuron protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q9NPF5

DNA methyltransferase 1-associated protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

P62333

26S proteasome regulatory subunit 10B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q4VCS5

Angiomotin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q9UJY5

ADP-ribosylation factor-binding protein GGA1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q9NVV9

THAP domain-containing protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q9NYP9

Protein Mis18-alpha

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q9H3R5

Centromere protein H

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q96F24

Nuclear receptor-binding factor 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q96KN3

Homeobox protein PKNOX2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5

Q13287

N-myc-interactor

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TAB5