Q8TBN0

Guanine nucleotide exchange factor for Rab-3A // UniProt Profile

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Species	H. sapiens
Number of Interactions	58 / 75
Average Interaction Score	0.899

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.987	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.987	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.987	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: pTarget method	LOCATE	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q8TBN0

Interaction Score

0.999

Q9NR12

(UniProtKB/Swiss-Prot/P) Details

PDZ and LIM domain protein 7

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Stress fiber (GO:0001725)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ruffle (GO:0001726)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.994	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell-cell adherens junction (GO:0005913)	0.994	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

Q8TBN0

Interaction Score

0.999

Q92551

(UniProtKB/Swiss-Prot/P) Details

Inositol hexakisphosphate kinase 1

Q8TBN0

Interaction Score

0.998

P61006

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-8A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Trans-Golgi network transport vesicle (GO:0030140)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cilium basal body (GO:0036064)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centriole (GO:0005814)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cilium (GO:0005929)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ciliary base (GO:0097546)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.998

Q4VCS5

(UniProtKB/Swiss-Prot/P) Details

Angiomotin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Signalosome (GO:0008180)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle (GO:0030139)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.992	Experimental: experimental	eSLDB	PubMed
Cytosol	Actin filament (GO:0005884)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle (GO:0001726)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Tight junction (GO:0005923)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.998

Q5JR59

(UniProtKB/Swiss-Prot/P) Details

Microtubule-associated tumor suppressor candidate 2

Q8TBN0

Interaction Score

0.998

Q96CV9

(UniProtKB/Swiss-Prot/P) Details

Optineurin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.937	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.994	Unknown: traceable author statement	GO	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.994	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.998

P25788

(UniProtKB/Swiss-Prot/P) Details

Proteasome subunit alpha type-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Proteasome complex (GO:0000502)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Proteasome core complex (GO:0005839)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Proteasome core complex, alpha-subunit complex (GO:0019773)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.902	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.902	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.902	Unknown: traceable author statement	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.997

P20336

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-3A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.993	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	0.993	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Acrosomal vesicle (GO:0001669)	0.993	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.993	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Clathrin sculpted acetylcholine transport vesicle membrane (GO:0060201)	0.993	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin sculpted glutamate transport vesicle membrane (GO:0060203)	0.993	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin sculpted monoamine transport vesicle membrane (GO:0070083)	0.993	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Clathrin sculpted gamma-aminobutyric acid transport vesicle membrane (GO:0061202)	0.993	Unknown: traceable author statement	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Axon (GO:0030424)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Terminal button (GO:0043195)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

IntAct, HPRD

Interaction Source Publication:

PubMed

, PubMed

Q8TBN0

Interaction Score

0.997

P62491

(UniProtKB/Swiss-Prot/P) Details

Ras-related protein Rab-11A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cleavage furrow (GO:0032154)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.8	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Unknown: HDA	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Multivesicular body (GO:0005771)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Kinetochore microtubule (GO:0005828)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

HPRD, IntAct, BioGRID

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.996

Q96DT6

(UniProtKB/Swiss-Prot/P) Details

Cysteine protease ATG4C

Q8TBN0

Interaction Score

0.996

O76011

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cuticular Ha4

Q8TBN0

Interaction Score

0.996

Q96QF0

(UniProtKB/Swiss-Prot/P) Details

Rab-3A-interacting protein

Q8TBN0

Interaction Score

0.996

O75031

(UniProtKB/Swiss-Prot/P) Details

Heat shock factor 2-binding protein

Q8TBN0

Interaction Score

0.995

Q8IY63

(UniProtKB/Swiss-Prot/P) Details

Angiomotin-like protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Signalosome (GO:0008180)	0.995	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.98	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Tight junction (GO:0005923)	0.98	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.993

Q8WUA2

(UniProtKB/Swiss-Prot/P) Details

Peptidyl-prolyl cis-trans isomerase-like 4

Q8TBN0

Interaction Score

0.992

Q8N9M5

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 102

Q8TBN0

Interaction Score

0.991

Q5BJF6

(UniProtKB/Swiss-Prot/P) Details

Outer dense fiber protein 2

Q8TBN0

Interaction Score

0.989

Q9NUQ9

(UniProtKB/Swiss-Prot/P) Details

Protein FAM49B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.79	Unknown: traceable author statement	GO	PubMed
Membrane	Cilium (GO:0005929)	0.958	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.958	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.987

Q2TAC2

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 57

Q8TBN0

Interaction Score

0.987

O75145

(UniProtKB/Swiss-Prot/P) Details

Liprin-alpha-3

Q8TBN0

Interaction Score

0.986

Q9UL33

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 2-like protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.991	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.991	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	TRAPP complex (GO:0030008)	0.991	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.991	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

Q8TBN0

Interaction Score

0.986

Q8IYI6

(UniProtKB/Swiss-Prot/P) Details

Exocyst complex component 8

Q8TBN0

Interaction Score

0.985

Q96Q05

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 9

Q8TBN0

Interaction Score

0.985

P47813

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic translation initiation factor 1A, X-chromosomal

Q8TBN0

Interaction Score

0.978

Q96A19

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 102A

Q8TBN0

Interaction Score

0.977

Q6NT04

(UniProtKB/Swiss-Prot/P) Details

Tigger transposable element-derived protein 7

Q8TBN0

Interaction Score

0.976

O43617

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	TRAPP complex (GO:0030008)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q8TBN0

Interaction Score

0.976

Q9NWQ9

(UniProtKB/Swiss-Prot/P) Details

Uncharacterized protein C14orf119

Q8TBN0

Interaction Score

0.975

Q13233

(UniProtKB/Swiss-Prot/P) Details

Mitogen-activated protein kinase kinase kinase 1

Q8TBN0

Interaction Score

0.959

A8MQ03

(UniProtKB/Swiss-Prot/P) Details

Cysteine-rich tail protein 1

Q8TBN0

Interaction Score

0.948

H3BUK6

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 2-like protein

Q8TBN0

Interaction Score

0.948

A0A0B4J294

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 2-like protein

Q8TBN0

Interaction Score

0.948

H3BQQ8

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 2-like protein

Q8TBN0

Interaction Score

0.944

Q6A162

(UniProtKB/Swiss-Prot/P) Details

Keratin, type I cytoskeletal 40

Q8TBN0

Interaction Score

0.94

Q6ZVK8

(UniProtKB/Swiss-Prot/P) Details

8-oxo-dGDP phosphatase NUDT18

Q8TBN0

Interaction Score

0.938

Q96D03

(UniProtKB/Swiss-Prot/P) Details

DNA damage-inducible transcript 4-like protein

Q8TBN0

Interaction Score

0.936

Q9GZU7

(UniProtKB/Swiss-Prot/P) Details

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Q8TBN0

Interaction Score

0.928

Q86TV6

(UniProtKB/Swiss-Prot/P) Details

Tetratricopeptide repeat protein 7B

Q8TBN0

Interaction Score

0.916

Q9Y2V7

(UniProtKB/Swiss-Prot/P) Details

Conserved oligomeric Golgi complex subunit 6

Q8TBN0

Interaction Score

0.91

Q8IX01

(UniProtKB/Swiss-Prot/P) Details

SURP and G-patch domain-containing protein 2

Q8TBN0

Interaction Score

0.91

Q9UPW6

(UniProtKB/Swiss-Prot/P) Details

DNA-binding protein SATB2

Q8TBN0

Interaction Score

0.909

Q2NKX9

(UniProtKB/Swiss-Prot/P) Details

UPF0561 protein C2orf68

Q8TBN0

Interaction Score

0.874

M0R2Z9

(UniProtKB/TrEmbl/P) Details

SURP and G-patch domain-containing protein 2

Q8TBN0

Interaction Score

0.849

Q9Y5R8

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.86	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	TRAPP complex (GO:0030008)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.998	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

Q8TBN0

Interaction Score

0.849

Q9Y296

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.86	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	TRAPP complex (GO:0030008)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi stack (GO:0005795)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Synapse (GO:0045202)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q8TBN0

Interaction Score

0.79

J3KQA9

(UniProtKB/TrEmbl/P) Details

Microtubule-associated tumor suppressor candidate 2

Q8TBN0

Interaction Score

0.79

Q8IYB1

(UniProtKB/Swiss-Prot/P) Details

Protein MB21D2

Q8TBN0

Interaction Score

0.79

E9PKS9

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 4

Q8TBN0

Interaction Score

0.79

E9PQE8

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 4

Q8TBN0

Interaction Score

0.79

A0A087WYS5

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 3

Q8TBN0

Interaction Score

0.79

J3KP27

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit 4

Q8TBN0

Interaction Score

0.79

A0A087WWM0

(UniProtKB/TrEmbl/P) Details

Trafficking protein particle complex subunit

Q8TBN0

Interaction Score

0.783

Q5TD97

(UniProtKB/Swiss-Prot/P) Details

Four and a half LIM domains protein 5

Q8TBN0

Interaction Score

0.745

P48553

(UniProtKB/Swiss-Prot/P) Details

Trafficking protein particle complex subunit 10

Q8TBN0

Interaction Score

0.728

Q59FT3

(UniProtKB/TrEmbl/P) Details

SATB family member 2 variant

Q8TBN0

Interaction Score

0.639

Q16623

(UniProtKB/Swiss-Prot/P) Details

Syntaxin-1A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.991	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.51	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.991	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Acrosomal vesicle (GO:0001669)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Synaptic vesicle (GO:0008021)	0.991	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Integral to synaptic vesicle membrane (GO:0030285)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actomyosin (GO:0042641)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Voltage-gated potassium channel complex (GO:0008076)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	SNARE complex (GO:0031201)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex (GO:0070033)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synaptobrevin 2-SNAP-25-syntaxin-1a complex (GO:0070044)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex (GO:0070032)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Presynaptic active zone membrane (GO:0048787)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q8TBN0

Interaction Score

0.296

Q7Z3S9

(UniProtKB/Swiss-Prot/P) Details

Notch homolog 2 N-terminal-like protein

Q8TBN0

Interaction Score

P43026

(UniProtKB/Swiss-Prot/P) Details

Growth/differentiation factor 5

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Q8TBN0

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8TBN0

Q9NR12

PDZ and LIM domain protein 7

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

Q92551

Inositol hexakisphosphate kinase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

P61006

Ras-related protein Rab-8A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

Q4VCS5

Angiomotin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

Q5JR59

Microtubule-associated tumor suppressor candidate 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

Q96CV9

Optineurin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

P25788

Proteasome subunit alpha type-3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

P20336

Ras-related protein Rab-3A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

P62491

Ras-related protein Rab-11A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

Q96DT6

Cysteine protease ATG4C

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

O76011

Keratin, type I cuticular Ha4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0

Q96QF0

Rab-3A-interacting protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8TBN0