Q8WY54

Protein phosphatase 1E // UniProt Profile

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Species	H. sapiens
Number of Interactions	60 / 88
Average Interaction Score	0.539

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q8WY54

Interaction Score

Q13257

(UniProtKB/Swiss-Prot/P) Details

Mitotic spindle assembly checkpoint protein MAD2A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.994	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Mitotic spindle (GO:0072686)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Kinetochore (GO:0000776)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

P51587

(UniProtKB/Swiss-Prot/P) Details

Breast cancer type 2 susceptibility protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	BRCA2-MAGE-D1 complex (GO:0033593)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Lateral element (GO:0000800)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

P55345

(UniProtKB/Swiss-Prot/P) Details

Protein arginine N-methyltransferase 2

Q8WY54

Interaction Score

Q13148

(UniProtKB/Swiss-Prot/P) Details

TAR DNA-binding protein 43

Q8WY54

Interaction Score

Q7Z7L1

(UniProtKB/Swiss-Prot/P) Details

Schlafen family member 11

Q8WY54

Interaction Score

Q9GZU8

(UniProtKB/Swiss-Prot/P) Details

Protein FAM192A

Q8WY54

Interaction Score

0.999

Q9UKE5

(UniProtKB/Swiss-Prot/P) Details

TRAF2 and NCK-interacting protein kinase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.999

Q13131

(UniProtKB/Swiss-Prot/P) Details

5'-AMP-activated protein kinase catalytic subunit alpha-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	AMP-activated protein kinase complex (GO:0031588)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Dendrite (GO:0030425)	0.937	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	0.937	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.937	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.999

P54646

(UniProtKB/Swiss-Prot/P) Details

5'-AMP-activated protein kinase catalytic subunit alpha-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytoplasmic stress granule (GO:0010494)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	AMP-activated protein kinase complex (GO:0031588)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.988	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.999

P04406

(UniProtKB/Swiss-Prot/P) Details

Glyceraldehyde-3-phosphate dehydrogenase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	GAIT complex (GO:0097452)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lipid particle (GO:0005811)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.988	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.972	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Vesicle (GO:0031982)	1	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.997

P61289

(UniProtKB/Swiss-Prot/P) Details

Proteasome activator complex subunit 3

Q8WY54

Interaction Score

0.996

Q12816

(UniProtKB/Swiss-Prot/P) Details

Trophinin

Q8WY54

Interaction Score

0.994

Q9NRI5

(UniProtKB/Swiss-Prot/P) Details

Disrupted in schizophrenia 1 protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centrosome (GO:0005813)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule (GO:0005874)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ciliary base (GO:0097546)	0.931	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Cell junction (GO:0030054)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	0.931	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.993

Q14155

(UniProtKB/Swiss-Prot/P) Details

Rho guanine nucleotide exchange factor 7

Q8WY54

Interaction Score

0.972

P22695

(UniProtKB/Swiss-Prot/P) Details

Cytochrome b-c1 complex subunit 2, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Mitochondrion	Mitochondrial respiratory chain complex III (GO:0005750)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial respiratory chain complex IV (GO:0005751)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.952

P05141

(UniProtKB/Swiss-Prot/P) Details

ADP/ATP translocase 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial nucleoid (GO:0042645)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: HDA	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	MMXD complex (GO:0071817)	0.992	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.986	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.986	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.986	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.986	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.952

P56962

(UniProtKB/Swiss-Prot/P) Details

Syntaxin-17

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: unspecified method	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.3	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Smooth endoplasmic reticulum membrane (GO:0030868)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Autophagic vacuole (GO:0005776)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Autophagic vacuole membrane (GO:0000421)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	HOPS complex (GO:0030897)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle (GO:0030134)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.995	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.995	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	SNARE complex (GO:0031201)	0.995	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.995	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.948

Q9BT73

(UniProtKB/Swiss-Prot/P) Details

Proteasome assembly chaperone 3

Q8WY54

Interaction Score

0.945

P04629

(UniProtKB/Swiss-Prot/P) Details

High affinity nerve growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.7	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.994	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.897	Predicted: pTarget method	LOCATE	PubMed
Membrane	Dendrite (GO:0030425)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.943

Q96EY1

(UniProtKB/Swiss-Prot/P) Details

DnaJ homolog subfamily A member 3, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin filament (GO:0005884)	0.972	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Extrinsic to plasma membrane (GO:0019897)	0.981	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.981	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.981	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	0.981	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.902

Q6ZRV2

(UniProtKB/Swiss-Prot/P) Details

Protein FAM83H

Q8WY54

Interaction Score

0.891

Q5W9H1

(UniProtKB/TrEmbl/P) Details

KIAA0142 splice variant 1

Q8WY54

Interaction Score

0.885

P48594

(UniProtKB/Swiss-Prot/P) Details

Serpin B4

Q8WY54

Interaction Score

0.86

P13073

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Q8WY54

Interaction Score

0.848

Q5JS54

(UniProtKB/Swiss-Prot/P) Details

Proteasome assembly chaperone 4

Q8WY54

Interaction Score

0.848

D6RB92

(UniProtKB/TrEmbl/P) Details

Proteasome assembly chaperone 4

Q8WY54

Interaction Score

0.81

O00483

(UniProtKB/Swiss-Prot/P) Details

Cytochrome c oxidase subunit NDUFA4

Q8WY54

Interaction Score

0.8

B3KQ25

(UniProtKB/TrEmbl/P) Details

cDNA FLJ32659 fis, clone TESTI1000045, highly similar to Proteasome activator complex subunit 3

Q8WY54

Interaction Score

0.783

P51571

(UniProtKB/Swiss-Prot/P) Details

Translocon-associated protein subunit delta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.86	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Sec61 translocon complex (GO:0005784)	0.999	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

0.745

Q5TEU4

(UniProtKB/Swiss-Prot/P) Details

Arginine-hydroxylase NDUFAF5, mitochondrial

Q8WY54

Interaction Score

0.728

C4P0D2

(UniProtKB/TrEmbl/P) Details

Disrupted in schizophrenia 1 isoform 45

Q8WY54

Interaction Score

0.7

Q71RB4

(UniProtKB/TrEmbl/P) Details

PP2121

Q8WY54

Interaction Score

0.637

Q9BX88

(UniProtKB/TrEmbl/P) Details

Magphinin delta

Q8WY54

Interaction Score

0.637

Q9BX90

(UniProtKB/TrEmbl/P) Details

Magphinin beta

Q8WY54

Interaction Score

0.637

Q9BX91

(UniProtKB/TrEmbl/P) Details

Magphinin alpha

Q8WY54

Interaction Score

0.296

Q86WV2

(UniProtKB/TrEmbl/P) Details

COX4I1 protein

Q8WY54

Interaction Score

0.24

H3BNV9

(UniProtKB/TrEmbl/P) Details

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Q8WY54

Interaction Score

0.21

Q53G26

(UniProtKB/TrEmbl/P) Details

DnaJ (Hsp40) homolog, subfamily A, member 3 variant

Q8WY54

Interaction Score

0.21

Q59E88

(UniProtKB/TrEmbl/P) Details

DnaJ (Hsp40) homolog, subfamily A, member 3 variant

Q8WY54

Interaction Score

A0A024R4F6

(UniProtKB/TrEmbl/P) Details

Protein-S-isoprenylcysteine O-methyltransferase

Q8WY54

Interaction Score

Q6NVC0

(UniProtKB/TrEmbl/P) Details

SLC25A5 protein

Q8WY54

Interaction Score

Q9BYF7

(UniProtKB/TrEmbl/P) Details

SCCA2b

Q8WY54

Interaction Score

O60725

(UniProtKB/Swiss-Prot/P) Details

Protein-S-isoprenylcysteine O-methyltransferase

Q8WY54

Interaction Score

Q29865

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-18 alpha chain

Q8WY54

Interaction Score

Q9TNN7

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-5 alpha chain

Q8WY54

Interaction Score

Q95HC2

(UniProtKB/TrEmbl/P) Details

HLA-C protein

Q8WY54

Interaction Score

Q95604

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-17 alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.989	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.973	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q8WY54

Interaction Score

P30499

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-1 alpha chain

Q8WY54

Interaction Score

X5DR71

(UniProtKB/TrEmbl/P) Details

Tyrosine-protein kinase receptor

Q8WY54

Interaction Score

P04222

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-3 alpha chain

Q8WY54

Interaction Score

P10321

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-7 alpha chain

Q8WY54

Interaction Score

P30501

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-2 alpha chain

Q8WY54

Interaction Score

P30504

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-4 alpha chain

Q8WY54

Interaction Score

P30505

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-8 alpha chain

Q8WY54

Interaction Score

P30508

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-12 alpha chain

Q8WY54

Interaction Score

P30510

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-14 alpha chain

Q8WY54

Interaction Score

Q6R739

(UniProtKB/TrEmbl/P) Details

HLA class I antigen

Q8WY54

Interaction Score

Q07000

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-15 alpha chain

Q8WY54

Interaction Score

Q29960

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-16 alpha chain

Q8WY54

Interaction Score

Q29963

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-6 alpha chain

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Q8WY54

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q8WY54

Q13257

Mitotic spindle assembly checkpoint protein MAD2A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

P51587

Breast cancer type 2 susceptibility protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

P55345

Protein arginine N-methyltransferase 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

Q13148

TAR DNA-binding protein 43

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

Q7Z7L1

Schlafen family member 11

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

Q9GZU8

Protein FAM192A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

Q9UKE5

TRAF2 and NCK-interacting protein kinase

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

Q13131

5'-AMP-activated protein kinase catalytic subunit alpha-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

P54646

5'-AMP-activated protein kinase catalytic subunit alpha-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

P04406

Glyceraldehyde-3-phosphate dehydrogenase

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

P61289

Proteasome activator complex subunit 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54

Q12816

Trophinin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q8WY54