Q92824

Proprotein convertase subtilisin/kexin type 5 // UniProt Profile

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Species	H. sapiens
Number of Interactions	42 / 48
Average Interaction Score	0.82

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	1	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi lumen (GO:0005796)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.987	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q92824

Interaction Score

0.999

P00797

(UniProtKB/Swiss-Prot/P) Details

Renin

Q92824

Interaction Score

0.999

Q03405

(UniProtKB/Swiss-Prot/P) Details

Urokinase plasminogen activator surface receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.902	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.902	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.902	Unknown: traceable author statement	GO	PubMed
Membrane	Invadopodium membrane (GO:0071438)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Extrinsic to membrane (GO:0019898)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Anchored to membrane (GO:0031225)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.999

Q8N2G4

(UniProtKB/Swiss-Prot/P) Details

Ly6/PLAUR domain-containing protein 1

Q92824

Interaction Score

0.997

P23229

(UniProtKB/Swiss-Prot/P) Details

Integrin alpha-6

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Filopodium (GO:0030175)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.992	Experimental: experimental	MatrixDB	PubMed
Extracellular	Basement membrane (GO:0005604)	0.992	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Alpha6-beta4 integrin complex (GO:0034676)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basal plasma membrane (GO:0009925)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Hemidesmosome (GO:0030056)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed
Membrane	Cell-cell adherens junction (GO:0005913)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.997

Q15262

(UniProtKB/Swiss-Prot/P) Details

Receptor-type tyrosine-protein phosphatase kappa

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Photoreceptor outer segment (GO:0001750)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Leading edge membrane (GO:0031256)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Adherens junction (GO:0005912)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.997

Q13291

(UniProtKB/Swiss-Prot/P) Details

Signaling lymphocytic activation molecule

Q92824

Interaction Score

0.996

P13727

(UniProtKB/Swiss-Prot/P) Details

Bone marrow proteoglycan

Q92824

Interaction Score

0.996

Q96T91

(UniProtKB/Swiss-Prot/P) Details

Glycoprotein hormone alpha-2

Q92824

Interaction Score

0.995

Q9Y2Y8

(UniProtKB/Swiss-Prot/P) Details

Proteoglycan 3

Q92824

Interaction Score

0.995

O15496

(UniProtKB/Swiss-Prot/P) Details

Group 10 secretory phospholipase A2

Q92824

Interaction Score

0.994

O00555

(UniProtKB/Swiss-Prot/P) Details

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.94	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.79	Unknown: unspecified method	The Human Protein Atlas	PubMed
Membrane	Cell projection (GO:0042995)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Unknown: non-traceable author statement	GO	PubMed
Membrane	Voltage-gated calcium channel complex (GO:0005891)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.993

P03971

(UniProtKB/Swiss-Prot/P) Details

Muellerian-inhibiting factor

Q92824

Interaction Score

0.993

Q6UWN0

(UniProtKB/Swiss-Prot/P) Details

Ly6/PLAUR domain-containing protein 4

Q92824

Interaction Score

0.99

P09093

(UniProtKB/Swiss-Prot/P) Details

Chymotrypsin-like elastase family member 3A

Q92824

Interaction Score

0.99

Q9Y5Q6

(UniProtKB/Swiss-Prot/P) Details

Insulin-like peptide INSL5

Q92824

Interaction Score

0.99

P28827

(UniProtKB/Swiss-Prot/P) Details

Receptor-type tyrosine-protein phosphatase mu

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Unknown: non-traceable author statement	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell-cell adherens junction (GO:0005913)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.987

Q92624

(UniProtKB/Swiss-Prot/P) Details

Amyloid protein-binding protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Microtubule associated complex (GO:0005875)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Microtubule (GO:0005874)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.979

P20382

(UniProtKB/Swiss-Prot/P) Details

Pro-MCH

Q92824

Interaction Score

0.979

Q7Z3S9

(UniProtKB/Swiss-Prot/P) Details

Notch homolog 2 N-terminal-like protein

Q92824

Interaction Score

0.954

Q5TG12

(UniProtKB/TrEmbl/P) Details

Receptor-type tyrosine-protein phosphatase kappa

Q92824

Interaction Score

0.916

Q9NS89

(UniProtKB/TrEmbl/P) Details

Voltage-dependent P/Q-type calcium channel subunit alpha

Q92824

Interaction Score

0.907

P60410

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-8

Q92824

Interaction Score

0.907

Q5T5A8

(UniProtKB/Swiss-Prot/P) Details

Late cornified envelope protein 3C

Q92824

Interaction Score

0.907

P26371

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 5-9

Q92824

Interaction Score

0.907

P60409

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-7

Q92824

Interaction Score

0.891

O75716

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase 16

Q92824

Interaction Score

0.877

Q59EZ1

(UniProtKB/TrEmbl/P) Details

Protein tyrosine phosphatase, receptor type, K variant

Q92824

Interaction Score

0.853

A0A087WW63

(UniProtKB/TrEmbl/P) Details

Voltage-dependent P/Q-type calcium channel subunit alpha

Q92824

Interaction Score

0.853

A0A1B0GVQ9

(UniProtKB/TrEmbl/P) Details

Voltage-dependent P/Q-type calcium channel subunit alpha

Q92824

Interaction Score

0.853

B5TYJ1

(UniProtKB/TrEmbl/P) Details

Voltage-dependent P/Q-type calcium channel subunit alpha

Q92824

Interaction Score

0.844

Q7Z417

(UniProtKB/Swiss-Prot/P) Details

Nuclear fragile X mental retardation-interacting protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Polysomal ribosome (GO:0042788)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic stress granule (GO:0010494)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q92824

Interaction Score

0.771

P54259

(UniProtKB/Swiss-Prot/P) Details

Atrophin-1

Q92824

Interaction Score

0.74

O76003

(UniProtKB/Swiss-Prot/P) Details

Glutaredoxin-3

Q92824

Interaction Score

0.7

Q02083

(UniProtKB/Swiss-Prot/P) Details

N-acylethanolamine-hydrolyzing acid amidase

Q92824

Interaction Score

0.691

Q9BQ66

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 4-12

Q92824

Interaction Score

0.691

Q86V38

(UniProtKB/TrEmbl/P) Details

Atrophin 1

Q92824

Interaction Score

0.688

M0R1I2

(UniProtKB/TrEmbl/P) Details

Urokinase plasminogen activator surface receptor

Q92824

Interaction Score

0.602

Q86WJ2

(UniProtKB/TrEmbl/P) Details

Mutant receptor type protein tyrosine phosphatase K

Q92824

Interaction Score

P60369

(UniProtKB/Swiss-Prot/P) Details

Keratin-associated protein 10-3

Q92824

Interaction Score

B8ZZI5

(UniProtKB/TrEmbl/P) Details

Serine/threonine-protein kinase 16

Q92824

Interaction Score

B4DPS1

(UniProtKB/TrEmbl/P) Details

cDNA FLJ60771, highly similar to Serine/threonine-protein kinase 16

Q92824

Interaction Score

P50222

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein MOX-2

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Q92824

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q92824

P00797

Renin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

Q03405

Urokinase plasminogen activator surface receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

Q8N2G4

Ly6/PLAUR domain-containing protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

P23229

Integrin alpha-6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

Q15262

Receptor-type tyrosine-protein phosphatase kappa

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

Q13291

Signaling lymphocytic activation molecule

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

P13727

Bone marrow proteoglycan

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

Q96T91

Glycoprotein hormone alpha-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

Q9Y2Y8

Proteoglycan 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

O15496

Group 10 secretory phospholipase A2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

O00555

Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824

P03971

Muellerian-inhibiting factor

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q92824