Q95460

Major histocompatibility complex class I-related gene protein // UniProt Profile

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Species	H. sapiens
Number of Interactions	34 / 38
Average Interaction Score	0.946

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.958	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.958	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.999	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q95460

Interaction Score

Q9Y287

(UniProtKB/Swiss-Prot/P) Details

Integral membrane protein 2B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi-associated vesicle membrane (GO:0030660)	0.996	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.999	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.999	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Integral to organelle membrane (GO:0031301)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q95460

Interaction Score

P61769

(UniProtKB/Swiss-Prot/P) Details

Beta-2-microglobulin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome lumen (GO:0031905)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.971	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.998	Unknown: HDA	GO	PubMed

Interaction Source Database:

DIP

Interaction Source Publication:

PubMed

Q95460

Interaction Score

Q95604

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-17 alpha chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.989	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.989	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.989	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.973	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q95460

Interaction Score

P13747

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, alpha chain E

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Recycling endosome membrane (GO:0055038)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Phagocytic vesicle membrane (GO:0030670)	0.882	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle membrane (GO:0012507)	0.882	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Unknown: traceable author statement	GO	PubMed
Membrane	MHC class I protein complex (GO:0042612)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q95460

Interaction Score

P29016

(UniProtKB/Swiss-Prot/P) Details

T-cell surface glycoprotein CD1b

Q95460

Interaction Score

0.999

Q96GX1

(UniProtKB/Swiss-Prot/P) Details

Tectonic-2

Q95460

Interaction Score

0.999

Q9NV96

(UniProtKB/Swiss-Prot/P) Details

Cell cycle control protein 50A

Q95460

Interaction Score

0.999

Q15165

(UniProtKB/Swiss-Prot/P) Details

Serum paraoxonase/arylesterase 2

Q95460

Interaction Score

0.998

Q92187

(UniProtKB/Swiss-Prot/P) Details

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Q95460

Interaction Score

0.998

Q53F39

(UniProtKB/Swiss-Prot/P) Details

Metallophosphoesterase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Endoplasmic reticulum exit site (GO:0070971)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cis-Golgi network (GO:0005801)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q95460

Interaction Score

0.997

Q401N2

(UniProtKB/Swiss-Prot/P) Details

Zinc-activated ligand-gated ion channel

Q95460

Interaction Score

0.996

Q86T26

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protease serine 11B

Q95460

Interaction Score

0.994

Q969F0

(UniProtKB/Swiss-Prot/P) Details

Fetal and adult testis-expressed transcript protein

Q95460

Interaction Score

0.99

Q6UX41

(UniProtKB/Swiss-Prot/P) Details

Butyrophilin-like protein 8

Q95460

Interaction Score

0.989

Q8NAC3

(UniProtKB/Swiss-Prot/P) Details

Interleukin-17 receptor C

Q95460

Interaction Score

0.986

P10321

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-7 alpha chain

Q95460

Interaction Score

0.98

Q29960

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-16 alpha chain

Q95460

Interaction Score

0.956

Q9HAT2

(UniProtKB/Swiss-Prot/P) Details

Sialate O-acetylesterase

Q95460

Interaction Score

0.939

Q95HC2

(UniProtKB/TrEmbl/P) Details

HLA-C protein

Q95460

Interaction Score

0.939

Q6R739

(UniProtKB/TrEmbl/P) Details

HLA class I antigen

Q95460

Interaction Score

0.93

A0A0A0MR93

(UniProtKB/TrEmbl/P) Details

Metallophosphoesterase 1

Q95460

Interaction Score

0.901

P30508

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-12 alpha chain

Q95460

Interaction Score

0.901

P30499

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-1 alpha chain

Q95460

Interaction Score

0.901

P30501

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-2 alpha chain

Q95460

Interaction Score

0.901

P30504

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-4 alpha chain

Q95460

Interaction Score

0.901

P30505

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-8 alpha chain

Q95460

Interaction Score

0.901

Q29963

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-6 alpha chain

Q95460

Interaction Score

0.901

P04222

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-3 alpha chain

Q95460

Interaction Score

0.901

Q29865

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-18 alpha chain

Q95460

Interaction Score

0.901

Q07000

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-15 alpha chain

Q95460

Interaction Score

0.901

P30510

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-14 alpha chain

Q95460

Interaction Score

0.901

Q9TNN7

(UniProtKB/Swiss-Prot/P) Details

HLA class I histocompatibility antigen, Cw-5 alpha chain

Q95460

Interaction Score

0.868

Q6DU44

(UniProtKB/TrEmbl/P) Details

HLA class I histocompatibility antigen, alpha chain E

Q95460

Interaction Score

0.699

O19682

(UniProtKB/TrEmbl/P) Details

HLA-E

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Q95460

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q95460

Q9Y287

Integral membrane protein 2B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

P61769

Beta-2-microglobulin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q95604

HLA class I histocompatibility antigen, Cw-17 alpha chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

P13747

HLA class I histocompatibility antigen, alpha chain E

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

P29016

T-cell surface glycoprotein CD1b

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q96GX1

Tectonic-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q9NV96

Cell cycle control protein 50A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q15165

Serum paraoxonase/arylesterase 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q92187

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q53F39

Metallophosphoesterase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q401N2

Zinc-activated ligand-gated ion channel

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460

Q86T26

Transmembrane protease serine 11B

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q95460