Q96DE5

Anaphase-promoting complex subunit 16 // UniProt Profile

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Species	H. sapiens
Number of Interactions	37 / 56
Average Interaction Score	0.931

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.98	Unknown: traceable author statement	GO	PubMed
Nucleus	Anaphase-promoting complex (GO:0005680)	0.98	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Kinetochore (GO:0000776)	0.98	Experimental: inferred from direct assay	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q96DE5

Interaction Score

O60566

(UniProtKB/Swiss-Prot/P) Details

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Anaphase-promoting complex (GO:0005680)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Spindle midzone (GO:0051233)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Condensed nuclear chromosome kinetochore (GO:0000778)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Condensed chromosome outer kinetochore (GO:0000940)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Kinetochore (GO:0000776)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q96DE5

Interaction Score

P30260

(UniProtKB/Swiss-Prot/P) Details

Cell division cycle protein 27 homolog

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Anaphase-promoting complex (GO:0005680)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Spindle (GO:0005819)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Spindle microtubule (GO:0005876)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q96DE5

Interaction Score

Q12834

(UniProtKB/Swiss-Prot/P) Details

Cell division cycle protein 20 homolog

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Anaphase-promoting complex (GO:0005680)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Spindle (GO:0005819)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Spindle pole (GO:0000922)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.999	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

Q96DE5

Interaction Score

Q15717

(UniProtKB/Swiss-Prot/P) Details

ELAV-like protein 1

Q96DE5

Interaction Score

Q9UJX3

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 7

Q96DE5

Interaction Score

Q9UJX5

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 4

Q96DE5

Interaction Score

P60006

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 15

Q96DE5

Interaction Score

Q9UJX2

(UniProtKB/Swiss-Prot/P) Details

Cell division cycle protein 23 homolog

Q96DE5

Interaction Score

0.999

Q13042

(UniProtKB/Swiss-Prot/P) Details

Cell division cycle protein 16 homolog

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.958	Unknown: traceable author statement	GO	PubMed
Nucleus	Anaphase-promoting complex (GO:0005680)	0.958	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Spindle (GO:0005819)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Spindle microtubule (GO:0005876)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

Q96DE5

Interaction Score

0.999

Q12888

(UniProtKB/Swiss-Prot/P) Details

TP53-binding protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Site of double-strand break (GO:0035861)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Replication fork (GO:0005657)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome, telomeric region (GO:0000781)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q96DE5

Interaction Score

0.999

Q7Z6E9

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase RBBP6

Q96DE5

Interaction Score

0.999

Q9UJX4

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 5

Q96DE5

Interaction Score

0.999

Q8N4N8

(UniProtKB/Swiss-Prot/P) Details

Kinesin-like protein KIF2B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleolus (GO:0005730)	0.902	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	0.902	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule cytoskeleton (GO:0015630)	0.999	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Mitotic spindle (GO:0072686)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Kinesin complex (GO:0005871)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Microtubule (GO:0005874)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Intercellular bridge (GO:0045171)	0.86	Unknown: unspecified method	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q96DE5

Interaction Score

0.998

Q9P2B7

(UniProtKB/Swiss-Prot/P) Details

Cilia- and flagella-associated protein 97

Q96DE5

Interaction Score

0.997

O75031

(UniProtKB/Swiss-Prot/P) Details

Heat shock factor 2-binding protein

Q96DE5

Interaction Score

0.995

O75791

(UniProtKB/Swiss-Prot/P) Details

GRB2-related adapter protein 2

Q96DE5

Interaction Score

0.994

Q86T82

(UniProtKB/Swiss-Prot/P) Details

Ubiquitin carboxyl-terminal hydrolase 37

Q96DE5

Interaction Score

0.99

Q9UJX6

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 2

Q96DE5

Interaction Score

0.99

Q9UM13

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 10

Q96DE5

Interaction Score

0.986

O43684

(UniProtKB/Swiss-Prot/P) Details

Mitotic checkpoint protein BUB3

Q96DE5

Interaction Score

0.986

P68431

(UniProtKB/Swiss-Prot/P) Details

Histone H3.1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome (GO:0000228)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleosome (GO:0000786)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nuclear nucleosome (GO:0000788)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q96DE5

Interaction Score

0.985

Q8NHZ8

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit CDC26

Q96DE5

Interaction Score

0.98

Q14676

(UniProtKB/Swiss-Prot/P) Details

Mediator of DNA damage checkpoint protein 1

Q96DE5

Interaction Score

0.976

Q9H1A4

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 1

Q96DE5

Interaction Score

0.969

A6NNK5

(UniProtKB/TrEmbl/P) Details

TP53-binding protein 1

Q96DE5

Interaction Score

0.966

O95922

(UniProtKB/Swiss-Prot/P) Details

Probable tubulin polyglutamylase TTLL1

Q96DE5

Interaction Score

0.955

Q9BS18

(UniProtKB/Swiss-Prot/P) Details

Anaphase-promoting complex subunit 13

Q96DE5

Interaction Score

0.955

G5EA39

(UniProtKB/TrEmbl/P) Details

Anaphase-promoting complex subunit 15

Q96DE5

Interaction Score

0.922

Q6PH81

(UniProtKB/Swiss-Prot/P) Details

UPF0547 protein C16orf87

Q96DE5

Interaction Score

0.784

F5H0F9

(UniProtKB/TrEmbl/P) Details

Anaphase-promoting complex subunit 5

Q96DE5

Interaction Score

0.784

G5EA36

(UniProtKB/TrEmbl/P) Details

Cell division cycle 27, isoform CRA_c

Q96DE5

Interaction Score

0.781

P01210

(UniProtKB/Swiss-Prot/P) Details

Proenkephalin-A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.86	Experimental: experimental	eSLDB	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.79	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.86	Unknown: traceable author statement	GO	PubMed
Membrane	Dendrite (GO:0030425)	0.997	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Nerve terminal (GO:0043679)	0.997	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Cell body fiber (GO:0070852)	0.997	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.997	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.997	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Symmetric synapse (GO:0032280)	0.997	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q96DE5

Interaction Score

0.692

Q6FI14

(UniProtKB/TrEmbl/P) Details

GRAP2 protein

Q96DE5

Interaction Score

0.692

Q9H6Y5

(UniProtKB/Swiss-Prot/P) Details

PDZ domain-containing protein MAGIX

Q96DE5

Interaction Score

0.692

Q4KMX6

(UniProtKB/TrEmbl/P) Details

ANAPC7 protein

Q96DE5

Interaction Score

0.692

Q69YV3

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp762H177

Q96DE5

Interaction Score

0.686

A1Z5I9

(UniProtKB/TrEmbl/P) Details

Mediator of DNA damage checkpoint 1 variant 1

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Q96DE5

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q96DE5

O60566

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

P30260

Cell division cycle protein 27 homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q12834

Cell division cycle protein 20 homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q15717

ELAV-like protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q9UJX3

Anaphase-promoting complex subunit 7

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q9UJX5

Anaphase-promoting complex subunit 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

P60006

Anaphase-promoting complex subunit 15

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q9UJX2

Cell division cycle protein 23 homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q13042

Cell division cycle protein 16 homolog

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q12888

TP53-binding protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q7Z6E9

E3 ubiquitin-protein ligase RBBP6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5

Q9UJX4

Anaphase-promoting complex subunit 5

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96DE5