Q96Q45

Transmembrane protein 237 // UniProt Profile

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Species	H. sapiens
Number of Interactions	49 / 60
Average Interaction Score	0.753

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Ciliary transition zone (GO:0035869)	0.971	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.971	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.971	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.971	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q96Q45

Interaction Score

0.993

P02675

(UniProtKB/Swiss-Prot/P) Details

Fibrinogen beta chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cell cortex (GO:0005938)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Platelet alpha granule (GO:0031091)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.996	Unknown: HDA	GO	PubMed
Extracellular	Fibrinogen complex (GO:0005577)	0.996	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.996	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: traceable author statement	GO	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.98	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	0.996	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.993

P01833

(UniProtKB/Swiss-Prot/P) Details

Polymeric immunoglobulin receptor

Q96Q45

Interaction Score

0.993

P04156

(UniProtKB/Swiss-Prot/P) Details

Major prion protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Inclusion body (GO:0016234)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.982	Experimental: experimental	Organelle	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.982	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendrite (GO:0030425)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Extrinsic to membrane (GO:0019898)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Anchored to external side of plasma membrane (GO:0031362)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.992

P01591

(UniProtKB/Swiss-Prot/P) Details

Immunoglobulin J chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Pentameric IgM immunoglobulin complex (GO:0071756)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Hexameric IgM immunoglobulin complex (GO:0071757)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Secretory IgA immunoglobulin complex (GO:0071751)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Secretory dimeric IgA immunoglobulin complex (GO:0071752)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Monomeric IgA immunoglobulin complex (GO:0071748)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.897	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.897	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.897	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.897	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.989

Q6UX40

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 107

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Flemming body (GO:0090543)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytosol (GO:0005829)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Lysosome (GO:0005764)	0.94	Predicted: pTarget method	LOCATE	PubMed
Membrane	Ciliary transition zone (GO:0035869)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	TCTN-B9D complex (GO:0036038)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, DIP

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.988

Q86UE4

(UniProtKB/Swiss-Prot/P) Details

Protein LYRIC

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.992	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.996	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Intercellular canaliculus (GO:0046581)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Tight junction (GO:0005923)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.988

O15259

(UniProtKB/Swiss-Prot/P) Details

Nephrocystin-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.969	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.969	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.969	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.969	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.969	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Motile cilium (GO:0031514)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Photoreceptor connecting cilium (GO:0032391)	0.996	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Unknown: non-traceable author statement	GO	PubMed
Membrane	Adherens junction (GO:0005912)	0.996	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.996	Experimental: inferred from direct assay	GO	PubMed
Membrane	Tight junction (GO:0005923)	0.996	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.987

Q86X19

(UniProtKB/Swiss-Prot/P) Details

Transmembrane protein 17

Q96Q45

Interaction Score

0.986

P51572

(UniProtKB/Swiss-Prot/P) Details

B-cell receptor-associated protein 31

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Lipid particle (GO:0005811)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear endoplasmic reticulum (GO:0097038)	0.972	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Sec61 translocon complex (GO:0005784)	1	Predicted: inferred from physical interaction	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi cisterna membrane (GO:0032580)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Clathrin-coated vesicle (GO:0030136)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.992	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.992	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.986

Q9NX76

(UniProtKB/Swiss-Prot/P) Details

CKLF-like MARVEL transmembrane domain-containing protein 6

Q96Q45

Interaction Score

0.986

Q8N5G2

(UniProtKB/Swiss-Prot/P) Details

Macoilin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.973	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.973	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Rough endoplasmic reticulum membrane (GO:0030867)	0.8	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuron projection terminus (GO:0044306)	0.991	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.991	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.991	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Synapse (GO:0045202)	0.991	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.986

P02788

(UniProtKB/Swiss-Prot/P) Details

Lactotransferrin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.994	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Phagocytic vesicle lumen (GO:0097013)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule (GO:0030141)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Specific granule (GO:0042581)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Predicted: pTarget method	LOCATE	PubMed
Extracellular	Extracellular region (GO:0005576)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Other organism cell membrane (GO:0044218)	0.997	Experimental: inferred from mutant phenotype	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.997	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.972	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.982

O00214

(UniProtKB/Swiss-Prot/P) Details

Galectin-8

Q96Q45

Interaction Score

0.98

Q8N766

(UniProtKB/Swiss-Prot/P) Details

ER membrane protein complex subunit 1

Q96Q45

Interaction Score

0.975

Q8N4V1

(UniProtKB/Swiss-Prot/P) Details

Membrane magnesium transporter 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	ER membrane protein complex (GO:0072546)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.958	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.958	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.958	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.968

Q9BV81

(UniProtKB/Swiss-Prot/P) Details

ER membrane protein complex subunit 6

Q96Q45

Interaction Score

0.968

Q9P0I2

(UniProtKB/Swiss-Prot/P) Details

ER membrane protein complex subunit 3

Q96Q45

Interaction Score

0.965

Q86UP2

(UniProtKB/Swiss-Prot/P) Details

Kinectin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.931	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.931	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.931	Unknown: traceable author statement	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.931	Unknown: traceable author statement	GO	PubMed
Cytosol	Vesicle (GO:0031982)	0.8	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.962

P53621

(UniProtKB/Swiss-Prot/P) Details

Coatomer subunit alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.979	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.979	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.979	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	COPI vesicle coat (GO:0030126)	0.979	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.979	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.955

Q96A33

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 47

Q96Q45

Interaction Score

0.955

P50402

(UniProtKB/Swiss-Prot/P) Details

Emerin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.994	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear outer membrane (GO:0005640)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear inner membrane (GO:0005637)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cortical endoplasmic reticulum (GO:0032541)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Spindle pole centrosome (GO:0031616)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule (GO:0005874)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.902	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.955

Q96AG4

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat-containing protein 59

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrial nucleoid (GO:0042645)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear envelope (GO:0005635)	0.937	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.994	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.902	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Organelle membrane (GO:0031090)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.955

Q9Y3E0

(UniProtKB/Swiss-Prot/P) Details

Vesicle transport protein GOT1B

Q96Q45

Interaction Score

0.953

Q9NP55

(UniProtKB/Swiss-Prot/P) Details

BPI fold-containing family A member 1

Q96Q45

Interaction Score

0.945

Q8TDL5

(UniProtKB/Swiss-Prot/P) Details

BPI fold-containing family B member 1

Q96Q45

Interaction Score

0.94

Q5JTV8

(UniProtKB/Swiss-Prot/P) Details

Torsin-1A-interacting protein 1

Q96Q45

Interaction Score

0.938

Q5VV42

(UniProtKB/Swiss-Prot/P) Details

Threonylcarbamoyladenosine tRNA methylthiotransferase

Q96Q45

Interaction Score

0.92

Q53YK7

(UniProtKB/TrEmbl/P) Details

Major prion protein

Q96Q45

Interaction Score

0.92

P08240

(UniProtKB/Swiss-Prot/P) Details

Signal recognition particle receptor subunit alpha

Q96Q45

Interaction Score

0.918

Q96DA0

(UniProtKB/Swiss-Prot/P) Details

Zymogen granule protein 16 homolog B

Q96Q45

Interaction Score

0.918

P11678

(UniProtKB/Swiss-Prot/P) Details

Eosinophil peroxidase

Q96Q45

Interaction Score

0.916

P51648

(UniProtKB/Swiss-Prot/P) Details

Fatty aldehyde dehydrogenase

Q96Q45

Interaction Score

0.916

Q07065

(UniProtKB/Swiss-Prot/P) Details

Cytoskeleton-associated protein 4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Lipid particle (GO:0005811)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.958	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.958	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.986	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Rough endoplasmic reticulum (GO:0005791)	0.986	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.986	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Lamellar body (GO:0042599)	0.986	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.96	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.96	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.657	Unknown: traceable author statement	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.657	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.657	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.835

P58546

(UniProtKB/Swiss-Prot/P) Details

Myotrophin

Q96Q45

Interaction Score

0.776

J3KN66

(UniProtKB/TrEmbl/P) Details

Torsin-1A-interacting protein 1

Q96Q45

Interaction Score

0.752

Q562E7

(UniProtKB/Swiss-Prot/P) Details

WD repeat-containing protein 81

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Extrinsic to endosome membrane (GO:0031313)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Autophagic vacuole membrane (GO:0000421)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.999	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.745

O43402

(UniProtKB/Swiss-Prot/P) Details

ER membrane protein complex subunit 8

Q96Q45

Interaction Score

0.745

Q13011

(UniProtKB/Swiss-Prot/P) Details

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.986	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.992	Experimental: experimental	eSLDB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.992	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Peroxisome (GO:0005777)	0.986	Experimental: experimental	eSLDB	PubMed
Cytosol	Peroxisome (GO:0005777)	0.986	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Peroxisome (GO:0005777)	0.986	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Peroxisomal matrix (GO:0005782)	0.986	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.986	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

0.64

F7VJQ1

(UniProtKB/Swiss-Prot/P) Details

Alternative prion protein

Q96Q45

Interaction Score

0.64

P35606

(UniProtKB/Swiss-Prot/P) Details

Coatomer subunit beta'

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	COPI vesicle coat (GO:0030126)	0.931	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.931	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

Q24JR4

(UniProtKB/TrEmbl/P) Details

WDR81 protein

Q96Q45

Interaction Score

P78406

(UniProtKB/Swiss-Prot/P) Details

mRNA export factor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Pore complex (GO:0046930)	0.8	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Fibrillar center (GO:0001650)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Mitotic spindle pole (GO:0097431)	0.999	Experimental: inferred from mutant phenotype	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q96Q45

Interaction Score

C9JNM7

(UniProtKB/TrEmbl/P) Details

Nephrocystin-1

Q96Q45

Interaction Score

O76094

(UniProtKB/Swiss-Prot/P) Details

Signal recognition particle subunit SRP72

Q96Q45

Interaction Score

P49458

(UniProtKB/Swiss-Prot/P) Details

Signal recognition particle 9 kDa protein

Q96Q45

Interaction Score

Q2TUW9

(UniProtKB/TrEmbl/P) Details

Lactoferrin

Q96Q45

Interaction Score

Q15006

(UniProtKB/Swiss-Prot/P) Details

ER membrane protein complex subunit 2

Q96Q45

Interaction Score

Q53Y03

(UniProtKB/TrEmbl/P) Details

COX4 neighbor, isoform CRA_a

Q96Q45

Interaction Score

Q69YG1

(UniProtKB/TrEmbl/P) Details

Myotrophin, isoform CRA_a

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Q96Q45

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q96Q45

P02675

Fibrinogen beta chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

P01833

Polymeric immunoglobulin receptor

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

P04156

Major prion protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

P01591

Immunoglobulin J chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

Q6UX40

Transmembrane protein 107

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

Q86UE4

Protein LYRIC

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

O15259

Nephrocystin-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

Q86X19

Transmembrane protein 17

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

P51572

B-cell receptor-associated protein 31

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

Q9NX76

CKLF-like MARVEL transmembrane domain-containing protein 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

Q8N5G2

Macoilin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45

P02788

Lactotransferrin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q96Q45