Q99594

Transcriptional enhancer factor TEF-5 // UniProt Profile

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Species	H. sapiens
Number of Interactions	30 / 36
Average Interaction Score	0.778

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleus (GO:0005634)	0.981	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.981	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.981	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcription factor complex (GO:0005667)	0.981	Predicted: inferred from biological aspect of ancestor	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q99594

Interaction Score

0.981

Q01094

(UniProtKB/Swiss-Prot/P) Details

Transcription factor E2F1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Mitochondrion	Mitochondrion (GO:0005739)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Rb-E2F complex (GO:0035189)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q99594

Interaction Score

0.981

Q9GZV5

(UniProtKB/Swiss-Prot/P) Details

WW domain-containing transcription regulator protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcription factor complex (GO:0005667)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

HPRD, IntAct, BioGRID

Interaction Source Publication:

PubMed

Q99594

Interaction Score

0.981

O00716

(UniProtKB/Swiss-Prot/P) Details

Transcription factor E2F3

Q99594

Interaction Score

0.981

Q99990

(UniProtKB/Swiss-Prot/P) Details

Transcription cofactor vestigial-like protein 1

Q99594

Interaction Score

0.981

Q14258

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin/ISG15 ligase TRIM25

Q99594

Interaction Score

0.981

Q9BTE3

(UniProtKB/Swiss-Prot/P) Details

Mini-chromosome maintenance complex-binding protein

Q99594

Interaction Score

0.981

P46937

(UniProtKB/Swiss-Prot/P) Details

Transcriptional coactivator YAP1

Q99594

Interaction Score

0.98

P61956

(UniProtKB/Swiss-Prot/P) Details

Small ubiquitin-related modifier 2

Q99594

Interaction Score

0.979

Q99623

(UniProtKB/Swiss-Prot/P) Details

Prohibitin-2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	0.986	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nuclear matrix (GO:0016363)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.96	Experimental: experimental	Human Proteinpedia	PubMed
Membrane	Cell periphery (GO:0071944)	0.986	Experimental: inferred from direct assay	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Presynaptic active zone (GO:0048786)	0.986	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q99594

Interaction Score

0.979

Q9UNE7

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase CHIP

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Ubiquitin conjugating enzyme complex (GO:0031371)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nuclear inclusion body (GO:0042405)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q99594

Interaction Score

0.979

Q14135

(UniProtKB/Swiss-Prot/P) Details

Transcription cofactor vestigial-like protein 4

Q99594

Interaction Score

0.976

Q8N8G2

(UniProtKB/Swiss-Prot/P) Details

Transcription cofactor vestigial-like protein 2

Q99594

Interaction Score

0.973

Q9UKE5

(UniProtKB/Swiss-Prot/P) Details

TRAF2 and NCK-interacting protein kinase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q99594

Interaction Score

0.969

A0A075B6E4

(UniProtKB/TrEmbl/P) Details

Transcription cofactor vestigial-like protein 4

Q99594

Interaction Score

0.963

P56545

(UniProtKB/Swiss-Prot/P) Details

C-terminal-binding protein 2

Q99594

Interaction Score

0.942

A0A0A6YYI5

(UniProtKB/TrEmbl/P) Details

Transcription cofactor vestigial-like protein 4

Q99594

Interaction Score

0.942

G5E9M7

(UniProtKB/TrEmbl/P) Details

Transcription cofactor vestigial-like protein 4

Q99594

Interaction Score

0.942

G5E9M9

(UniProtKB/TrEmbl/P) Details

Transcription cofactor vestigial-like protein 4

Q99594

Interaction Score

0.94

Q9HB75

(UniProtKB/Swiss-Prot/P) Details

p53-induced death domain-containing protein 1

Q99594

Interaction Score

0.922

Q96AC6

(UniProtKB/Swiss-Prot/P) Details

Kinesin-like protein KIFC2

Q99594

Interaction Score

0.893

Q86T74

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp451O0517

Q99594

Interaction Score

0.844

P08559

(UniProtKB/Swiss-Prot/P) Details

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Q99594

Interaction Score

0.785

A0A2R8YEU8

(UniProtKB/TrEmbl/P) Details

Kinesin-like protein

Q99594

Interaction Score

0.785

P34932

(UniProtKB/Swiss-Prot/P) Details

Heat shock 70 kDa protein 4

Q99594

Interaction Score

0.687

Q9Y587

(UniProtKB/Swiss-Prot/P) Details

AP-4 complex subunit sigma-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.956	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.956	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Trans-Golgi network membrane (GO:0032588)	0.956	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endosome lumen (GO:0031904)	0.956	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q99594

Interaction Score

Q9P025

(UniProtKB/TrEmbl/P) Details

HSPC135

Q99594

Interaction Score

Q8N3Z3

(UniProtKB/Swiss-Prot/P) Details

GTP-binding protein 8

Q99594

Interaction Score

P49327

(UniProtKB/Swiss-Prot/P) Details

Fatty acid synthase

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Glycogen granule (GO:0042587)	1	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.91	Predicted: pTarget method	LOCATE	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.992	Unknown: HDA	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q99594

Interaction Score

Q5SQP8

(UniProtKB/TrEmbl/P) Details

C-terminal-binding protein 2

Q99594

Interaction Score

P12883

(UniProtKB/Swiss-Prot/P) Details

Myosin-7

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Myofibril (GO:0030016)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Sarcomere (GO:0030017)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Z disc (GO:0030018)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Myosin complex (GO:0016459)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Myosin filament (GO:0032982)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Muscle myosin complex (GO:0005859)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Stress fiber (GO:0001725)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

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Q99594

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q99594

Q01094

Transcription factor E2F1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q9GZV5

WW domain-containing transcription regulator protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

O00716

Transcription factor E2F3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q99990

Transcription cofactor vestigial-like protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q14258

E3 ubiquitin/ISG15 ligase TRIM25

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q9BTE3

Mini-chromosome maintenance complex-binding protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

P46937

Transcriptional coactivator YAP1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

P61956

Small ubiquitin-related modifier 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q99623

Prohibitin-2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q9UNE7

E3 ubiquitin-protein ligase CHIP

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q14135

Transcription cofactor vestigial-like protein 4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594

Q8N8G2

Transcription cofactor vestigial-like protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q99594