Q9UN30

Sex comb on midleg-like protein 1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	37 / 46
Average Interaction Score	0.648

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleus (GO:0005634)	0.987	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.987	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	0.987	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q9UN30

Interaction Score

0.987

Q99496

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase RING2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.94	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	MLL1 complex (GO:0071339)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PcG protein complex (GO:0031519)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PRC1 complex (GO:0035102)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Euchromatin (GO:0000791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Sex chromatin (GO:0001739)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

0.987

Q9HC52

(UniProtKB/Swiss-Prot/P) Details

Chromobox protein homolog 8

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	PcG protein complex (GO:0031519)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PRC1 complex (GO:0035102)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Heterochromatin (GO:0000792)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

0.987

O00257

(UniProtKB/Swiss-Prot/P) Details

E3 SUMO-protein ligase CBX4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	PcG protein complex (GO:0031519)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PRC1 complex (GO:0035102)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

0.987

Q14781

(UniProtKB/Swiss-Prot/P) Details

Chromobox protein homolog 2

Q9UN30

Interaction Score

0.987

P35226

(UniProtKB/Swiss-Prot/P) Details

Polycomb complex protein BMI-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Ubiquitin ligase complex (GO:0000151)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	PcG protein complex (GO:0031519)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	PRC1 complex (GO:0035102)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.7	Predicted: pTarget method	LOCATE	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

0.987

P78364

(UniProtKB/Swiss-Prot/P) Details

Polyhomeotic-like protein 1

Q9UN30

Interaction Score

0.987

Q8IXK0

(UniProtKB/Swiss-Prot/P) Details

Polyhomeotic-like protein 2

Q9UN30

Interaction Score

0.987

P35227

(UniProtKB/Swiss-Prot/P) Details

Polycomb group RING finger protein 2

Q9UN30

Interaction Score

0.987

Q8NDX5

(UniProtKB/Swiss-Prot/P) Details

Polyhomeotic-like protein 3

Q9UN30

Interaction Score

0.987

Q9BSM1

(UniProtKB/Swiss-Prot/P) Details

Polycomb group RING finger protein 1

Q9UN30

Interaction Score

0.987

O95503

(UniProtKB/Swiss-Prot/P) Details

Chromobox protein homolog 6

Q9UN30

Interaction Score

0.987

P17980

(UniProtKB/Swiss-Prot/P) Details

26S proteasome regulatory subunit 6A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytoplasmic mRNA processing body (GO:0000932)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Proteasome complex (GO:0000502)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosolic proteasome complex (GO:0031597)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Proteasome accessory complex (GO:0022624)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Proteasome regulatory particle, base subcomplex (GO:0008540)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear proteasome complex (GO:0031595)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

0.986

Q15717

(UniProtKB/Swiss-Prot/P) Details

ELAV-like protein 1

Q9UN30

Interaction Score

0.985

Q86UE8

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein kinase tousled-like 2

Q9UN30

Interaction Score

0.984

Q9BWV3

(UniProtKB/Swiss-Prot/P) Details

Cytidine and dCMP deaminase domain-containing protein 1

Q9UN30

Interaction Score

0.982

Q8IY63

(UniProtKB/Swiss-Prot/P) Details

Angiomotin-like protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.958	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.995	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Signalosome (GO:0008180)	0.995	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.79	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.79	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell junction (GO:0030054)	0.98	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Tight junction (GO:0005923)	0.98	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

, PubMed

Q9UN30

Interaction Score

0.899

Q0D2I5

(UniProtKB/Swiss-Prot/P) Details

Intermediate filament family orphan 1

Q9UN30

Interaction Score

0.899

Q9Y4M3

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp586I2223

Q9UN30

Interaction Score

0.899

Q6N083

(UniProtKB/TrEmbl/P) Details

Uncharacterized protein DKFZp686A1782

Q9UN30

Interaction Score

0.899

Q6GMQ3

(UniProtKB/TrEmbl/P) Details

PHC1 protein

Q9UN30

Interaction Score

0.849

P29074

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein phosphatase non-receptor type 4

Q9UN30

Interaction Score

0.79

E7EX82

(UniProtKB/TrEmbl/P) Details

Polyhomeotic-like protein 3

Q9UN30

Interaction Score

0.79

A0A0A0MSI2

(UniProtKB/TrEmbl/P) Details

Polyhomeotic-like protein 2

Q9UN30

Interaction Score

0.78

Q96JJ6

(UniProtKB/Swiss-Prot/P) Details

Junctophilin-4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.897	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Junctional membrane complex (GO:0030314)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Junctional sarcoplasmic reticulum membrane (GO:0014701)	0.897	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.79	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.79	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Smooth endoplasmic reticulum (GO:0005790)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.931	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.931	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

0.691

Q53SF7

(UniProtKB/Swiss-Prot/P) Details

Cordon-bleu protein-like 1

Q9UN30

Interaction Score

0.691

A0JNW5

(UniProtKB/Swiss-Prot/P) Details

UHRF1-binding protein 1-like

Q9UN30

Interaction Score

Q8NEL9

(UniProtKB/Swiss-Prot/P) Details

Phospholipase DDHD1

Q9UN30

Interaction Score

Q9Y2J2

(UniProtKB/Swiss-Prot/P) Details

Band 4.1-like protein 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.937	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.937	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Juxtaparanode region of axon (GO:0044224)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Paranode region of axon (GO:0033270)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axolemma (GO:0030673)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct, BioGRID

Interaction Source Publication:

PubMed

Q9UN30

Interaction Score

P26045

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein phosphatase non-receptor type 3

Q9UN30

Interaction Score

Q6P593

(UniProtKB/TrEmbl/P) Details

IFFO1 protein

Q9UN30

Interaction Score

A0A0D9SG04

(UniProtKB/TrEmbl/P) Details

Cordon-bleu protein-like 1

Q9UN30

Interaction Score

Q96MW1

(UniProtKB/Swiss-Prot/P) Details

Coiled-coil domain-containing protein 43

Q9UN30

Interaction Score

A0A0A0MRA8

(UniProtKB/TrEmbl/P) Details

Band 4.1-like protein 3

Q9UN30

Interaction Score

A8K968

(UniProtKB/TrEmbl/P) Details

Band 4.1-like protein 3

Q9UN30

Interaction Score

Q8NFN8

(UniProtKB/Swiss-Prot/P) Details

Probable G-protein coupled receptor 156

Q9UN30

Interaction Score

Q59EA3

(UniProtKB/TrEmbl/P) Details

Cadherin 5, type 2 preproprotein variant

Q9UN30

Interaction Score

P33151

(UniProtKB/Swiss-Prot/P) Details

Cadherin-5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	External side of plasma membrane (GO:0009897)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell-cell adherens junction (GO:0005913)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Tight junction (GO:0005923)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

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Q9UN30

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q9UN30

Q99496

E3 ubiquitin-protein ligase RING2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

Q9HC52

Chromobox protein homolog 8

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

O00257

E3 SUMO-protein ligase CBX4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

Q14781

Chromobox protein homolog 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

P35226

Polycomb complex protein BMI-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

P78364

Polyhomeotic-like protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

Q8IXK0

Polyhomeotic-like protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

P35227

Polycomb group RING finger protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

Q8NDX5

Polyhomeotic-like protein 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

Q9BSM1

Polycomb group RING finger protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

O95503

Chromobox protein homolog 6

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30

P17980

26S proteasome regulatory subunit 6A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UN30