Q9UNI1

Chymotrypsin-like elastase family member 1 // UniProt Profile

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Species	H. sapiens
Number of Interactions	29 / 47
Average Interaction Score	0.441

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.91	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

Q9UNI1

Interaction Score

0.993

P01009

(UniProtKB/Swiss-Prot/P) Details

Alpha-1-antitrypsin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.994	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum lumen (GO:0005788)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.999	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	ER to Golgi transport vesicle (GO:0030134)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.992	Experimental: inferred from mutant phenotype	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.992	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.994	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.99

P19957

(UniProtKB/Swiss-Prot/P) Details

Elafin

Q9UNI1

Interaction Score

0.987

P05814

(UniProtKB/Swiss-Prot/P) Details

Beta-casein

Q9UNI1

Interaction Score

0.983

P01011

(UniProtKB/Swiss-Prot/P) Details

Alpha-1-antichymotrypsin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.931	Experimental: experimental	eSLDB	PubMed
Cytosol	Intracellular (GO:0005622)	0.902	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.902	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.931	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.931	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.897	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.897	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.897	Unknown: HDA	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.897	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.902	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.983

P01023

(UniProtKB/Swiss-Prot/P) Details

Alpha-2-macroglobulin

Q9UNI1

Interaction Score

0.98

P08519

(UniProtKB/Swiss-Prot/P) Details

Apolipoprotei

Q9UNI1

Interaction Score

0.969

Q9NRI5

(UniProtKB/Swiss-Prot/P) Details

Disrupted in schizophrenia 1 protein

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.7	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centrosome (GO:0005813)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule (GO:0005874)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ciliary base (GO:0097546)	0.931	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Cell junction (GO:0030054)	0.931	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	0.931	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.968

P48634

(UniProtKB/Swiss-Prot/P) Details

Protein PRRC2A

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.988	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.972	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.972	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.992	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.948

P78371

(UniProtKB/Swiss-Prot/P) Details

T-complex protein 1 subunit beta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
N/A	Zona pellucida receptor complex (GO:0002199)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Myelin sheath (GO:0043209)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cell body (GO:0044297)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Chaperonin-containing T-complex (GO:0005832)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Azurophil granule lumen (GO:0035578)	0.3	Unknown: traceable author statement	GO	PubMed
Cytosol	Microtubule (GO:0005874)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.86	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.916

O15379

(UniProtKB/Swiss-Prot/P) Details

Histone deacetylase 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.972	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcriptional repressor complex (GO:0017053)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Histone deacetylase complex (GO:0000118)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Spindle microtubule (GO:0005876)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.8	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.915

P42694

(UniProtKB/Swiss-Prot/P) Details

Probable helicase with zinc finger domain

Q9UNI1

Interaction Score

0.831

Q9UPV0

(UniProtKB/Swiss-Prot/P) Details

Centrosomal protein of 164 kDa

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Centriole (GO:0005814)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ciliary transition fiber (GO:0097539)	0.96	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular space (GO:0005615)	0.3	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	MatrixDB	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.688

P10071

(UniProtKB/Swiss-Prot/P) Details

Transcriptional activator GLI3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.972	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear speck (GO:0016607)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Srb-mediator complex (GO:0016592)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Transcriptional repressor complex (GO:0017053)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Axoneme (GO:0005930)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cilium (GO:0005929)	0.86	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ciliary base (GO:0097546)	0.86	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9UNI1

Interaction Score

0.64

Q9P2F8

(UniProtKB/Swiss-Prot/P) Details

Signal-induced proliferation-associated 1-like protein 2

Q9UNI1

Interaction Score

B9A023

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E type 2

Q9UNI1

Interaction Score

Q9H4B7

(UniProtKB/Swiss-Prot/P) Details

Tubulin beta-1 chain

Q9UNI1

Interaction Score

Q9NRG4

(UniProtKB/Swiss-Prot/P) Details

N-lysine methyltransferase SMYD2

Q9UNI1

Interaction Score

C4P0D2

(UniProtKB/TrEmbl/P) Details

Disrupted in schizophrenia 1 isoform 45

Q9UNI1

Interaction Score

Q59FE1

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E member 2 variant

Q9UNI1

Interaction Score

Q53RG0

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E member 2, isoform CRA_c

Q9UNI1

Interaction Score

O60573

(UniProtKB/Swiss-Prot/P) Details

Eukaryotic translation initiation factor 4E type 2

Q9UNI1

Interaction Score

B8ZZL3

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E type 2

Q9UNI1

Interaction Score

B8ZZ50

(UniProtKB/TrEmbl/P) Details

Eukaryotic translation initiation factor 4E type 2

Q9UNI1

Interaction Score

Q70EL1

(UniProtKB/Swiss-Prot/P) Details

Inactive ubiquitin carboxyl-terminal hydrolase 54

Q9UNI1

Interaction Score

Q9BWN1

(UniProtKB/Swiss-Prot/P) Details

Proline-rich protein 14

Q9UNI1

Interaction Score

Q6W2J9

(UniProtKB/Swiss-Prot/P) Details

BCL-6 corepressor

Q9UNI1

Interaction Score

A5PL33

(UniProtKB/Swiss-Prot/P) Details

Protein KRBA1

Q9UNI1

Interaction Score

A0A0C4DH65

(UniProtKB/TrEmbl/P) Details

Protein KRBA1

Q9UNI1

Interaction Score

Q5VUA4

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 318

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Q9UNI1

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q9UNI1

P01009

Alpha-1-antitrypsin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P19957

Elafin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P05814

Beta-casein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P01011

Alpha-1-antichymotrypsin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P01023

Alpha-2-macroglobulin

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P08519

Apolipoprotei

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

Q9NRI5

Disrupted in schizophrenia 1 protein

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P48634

Protein PRRC2A

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P78371

T-complex protein 1 subunit beta

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

O15379

Histone deacetylase 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

P42694

Probable helicase with zinc finger domain

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1

Q9UPV0

Centrosomal protein of 164 kDa

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9UNI1