Q9Y2L1

Exosome complex exonuclease RRP44 // UniProt Profile

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Species	H. sapiens
Number of Interactions	109 / 151
Average Interaction Score	0.929

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	eSLDB	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.999	Experimental: experimental	Organelle	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

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Interactions

All Details

Q9Y2L1

Interaction Score

Q14974

(UniProtKB/Swiss-Prot/P) Details

Importin subunit beta-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Endomembrane system (GO:0012505)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytoplasmic stress granule (GO:0010494)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Pore complex (GO:0046930)	0.8	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nuclear periphery (GO:0034399)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum tubular network (GO:0071782)	0.8	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.902	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.902	Experimental: experimental	MatrixDB	PubMed
Extracellular	Host cell (GO:0043657)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.86	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q01780

(UniProtKB/Swiss-Prot/P) Details

Exosome component 10

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcriptionally active chromatin (GO:0035327)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.3	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

P62826

(UniProtKB/Swiss-Prot/P) Details

GTP-binding nuclear protein Ran

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.972	Experimental: inferred from direct assay	GO	PubMed
Membrane	Flemming body (GO:0090543)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear envelope (GO:0005635)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear pore (GO:0005643)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Secretory-pathway	Recycling endosome (GO:0055037)	0.86	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Melanosome (GO:0042470)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Centriole (GO:0005814)	0.999	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromatin (GO:0000785)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.972	Experimental: experimental	MatrixDB	PubMed
Extracellular	Host cell (GO:0043657)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.972	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.972	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q9NWV8

(UniProtKB/Swiss-Prot/P) Details

BRISC and BRCA1-A complex member 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	BRISC complex (GO:0070552)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	BRCA1-A complex (GO:0070531)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q06265

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP45

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasmic exosome (RNase complex) (GO:0000177)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Unknown: non-traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome (GO:0000228)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q9NQT5

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP40

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasmic exosome (RNase complex) (GO:0000177)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcriptionally active chromatin (GO:0035327)	1	Experimental: inferred from mutant phenotype	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

P53041

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Perikaryon (GO:0043204)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.3	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q13868

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.992	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic exosome (RNase complex) (GO:0000177)	0.992	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.992	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q9NPD3

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP41

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic exosome (RNase complex) (GO:0000177)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intermediate filament cytoskeleton (GO:0045111)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcriptionally active chromatin (GO:0035327)	1	Experimental: inferred from mutant phenotype	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q16181

(UniProtKB/Swiss-Prot/P) Details

Septin-7

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.992	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Midbody (GO:0030496)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cleavage furrow (GO:0032154)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Septin complex (GO:0031105)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Spindle (GO:0005819)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Stress fiber (GO:0001725)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Axoneme (GO:0005930)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Sperm annulus (GO:0097227)	0.992	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q9NQT4

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP46

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.971	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic exosome (RNase complex) (GO:0000177)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Transcriptionally active chromatin (GO:0035327)	1	Experimental: inferred from mutant phenotype	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q12888

(UniProtKB/Swiss-Prot/P) Details

TP53-binding protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Site of double-strand break (GO:0035861)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromosome, telomeric region (GO:0000784)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Replication fork (GO:0005657)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Condensed chromosome kinetochore (GO:0000777)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Chromosome, telomeric region (GO:0000781)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

P29084

(UniProtKB/Swiss-Prot/P) Details

Transcription initiation factor IIE subunit beta

Q9Y2L1

Interaction Score

P18754

(UniProtKB/Swiss-Prot/P) Details

Regulator of chromosome condensation

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.94	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear membrane (GO:0031965)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Condensed nuclear chromosome (GO:0000794)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear chromatin (GO:0000790)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromatin (GO:0000785)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q9Y3B2

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component CSL4

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.971	Unknown: non-traceable author statement	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.971	Experimental: experimental	Organelle	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear body (GO:0016604)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q5JWF2

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleolus (GO:0005730)	0.992	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Heterotrimeric G-protein complex (GO:0005834)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q96B26

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP43

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Exosome (RNase complex) (GO:0000178)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasmic exosome (RNase complex) (GO:0000177)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Unknown: traceable author statement	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.8	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nuclear exosome (RNase complex) (GO:0000176)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.998	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

HPRD, BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q00535

(UniProtKB/Swiss-Prot/P) Details

Cyclin-dependent-like kinase 5

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cyclin-dependent protein kinase 5 holoenzyme complex (GO:0016533)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.992	Unknown: traceable author statement	GO	PubMed
Cytosol	Microtubule (GO:0005874)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Growth cone (GO:0030426)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Filopodium (GO:0030175)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendrite (GO:0030425)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q5S007

(UniProtKB/Swiss-Prot/P) Details

Leucine-rich repeat serine/threonine-protein kinase 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Neuronal cell body (GO:0043025)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perikaryon (GO:0043204)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Intracellular (GO:0005622)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Inclusion body (GO:0016234)	1	Experimental: inferred from mutant phenotype	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial matrix (GO:0005759)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrial membrane (GO:0031966)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	External side of mitochondrial outer membrane (GO:0032473)	1	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Golgi-associated vesicle (GO:0005798)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Trans-Golgi network (GO:0005802)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Multivesicular body, internal vesicle (GO:0097487)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Amphisome (GO:0044753)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Synaptic vesicle membrane (GO:0030672)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Growth cone (GO:0030426)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Microvillus (GO:0005902)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendrite (GO:0030425)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendrite cytoplasm (GO:0032839)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Axon (GO:0030424)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Terminal button (GO:0043195)	1	Unknown: traceable author statement	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q96D46

(UniProtKB/Swiss-Prot/P) Details

60S ribosomal export protein NMD3

Q9Y2L1

Interaction Score

Q9BV86

(UniProtKB/Swiss-Prot/P) Details

N-terminal Xaa-Pro-Lys N-methyltransferase 1

Q9Y2L1

Interaction Score

P42285

(UniProtKB/Swiss-Prot/P) Details

Exosome RNA helicase MTR4

Q9Y2L1

Interaction Score

Q9BV68

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase RNF126

Q9Y2L1

Interaction Score

Q14684

(UniProtKB/Swiss-Prot/P) Details

Ribosomal RNA processing protein 1 homolog B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Preribosome, large subunit precursor (GO:0030687)	0.853	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Preribosome, small subunit precursor (GO:0030688)	0.853	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.853	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Human Proteinpedia	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Granular component (GO:0001652)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Euchromatin (GO:0000791)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Heterochromatin (GO:0000792)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q14145

(UniProtKB/Swiss-Prot/P) Details

Kelch-like ECH-associated protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cul3-RING ubiquitin ligase complex (GO:0031463)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Midbody (GO:0030496)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.988	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Microtubule organizing center (GO:0005815)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Actin filament (GO:0005884)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q9NRC8

(UniProtKB/Swiss-Prot/P) Details

NAD-dependent protein deacetylase sirtuin-7

Q9Y2L1

Interaction Score

P05412

(UniProtKB/Swiss-Prot/P) Details

Transcription factor AP-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Transcriptional repressor complex (GO:0017053)	1	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	AP1 complex (GO:0035976)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Chromosome (GO:0005694)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear chromosome (GO:0000228)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nuclear euchromatin (GO:0005719)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

P53999

(UniProtKB/Swiss-Prot/P) Details

Activated RNA polymerase II transcriptional coactivator p15

Q9Y2L1

Interaction Score

Q9Y295

(UniProtKB/Swiss-Prot/P) Details

Developmentally-regulated GTP-binding protein 1

Q9Y2L1

Interaction Score

P18615

(UniProtKB/Swiss-Prot/P) Details

Negative elongation factor E

Q9Y2L1

Interaction Score

Q13618

(UniProtKB/Swiss-Prot/P) Details

Cullin-3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cul3-RING ubiquitin ligase complex (GO:0031463)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.937	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.937	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.86	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Polar microtubule (GO:0005827)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Sperm flagellum (GO:0036126)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.86	Unknown: HDA	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q13901

(UniProtKB/Swiss-Prot/P) Details

Nuclear nucleic acid-binding protein C1D

Q9Y2L1

Interaction Score

Q99523

(UniProtKB/Swiss-Prot/P) Details

Sortilin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Coated pit (GO:0005905)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Experimental: experimental	eSLDB	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi cisterna membrane (GO:0032580)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Early endosome (GO:0005769)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Lysosome (GO:0005764)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle membrane (GO:0030659)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Clathrin-coated vesicle (GO:0030136)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Trans-Golgi network transport vesicle (GO:0030140)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendrite (GO:0030425)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Vesicle (GO:0031982)	1	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

P00533

(UniProtKB/Swiss-Prot/P) Details

Epidermal growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Endomembrane system (GO:0012505)	0.972	Experimental: experimental	Organelle	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.972	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.972	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.994	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear membrane (GO:0031965)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Clathrin coated vesicle membrane (GO:0030665)	0.999	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.86	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.86	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Membrane raft (GO:0045121)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	AP-2 adaptor complex (GO:0030122)	1	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Shc-EGFR complex (GO:0070435)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	1	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

O95467

(UniProtKB/Swiss-Prot/P) Details

Neuroendocrine secretory protein 55

Q9Y2L1

Interaction Score

Q96NY9

(UniProtKB/Swiss-Prot/P) Details

Crossover junction endonuclease MUS81

Q9Y2L1

Interaction Score

P22392

(UniProtKB/Swiss-Prot/P) Details

Nucleoside diphosphate kinase B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.986	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.986	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.986	Unknown: traceable author statement	GO	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrial membrane (GO:0031966)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Unknown: HDA	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	0.992	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Secretory granule lumen (GO:0034774)	0.3	Unknown: traceable author statement	GO	PubMed
Cytosol	Intermediate filament (GO:0005882)	0.986	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell periphery (GO:0071944)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Ruffle (GO:0001726)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Lamellipodium (GO:0030027)	1	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.986	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

O00186

(UniProtKB/Swiss-Prot/P) Details

Syntaxin-binding protein 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.997	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.997	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.997	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.997	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.94	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Phagocytic vesicle (GO:0045335)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Specific granule (GO:0042581)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Platelet alpha granule (GO:0031091)	0.994	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Tertiary granule (GO:0070820)	0.994	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.902	Experimental: inferred from direct assay	GO	PubMed
Membrane	Apical plasma membrane (GO:0016324)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Basolateral plasma membrane (GO:0016323)	0.902	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.997	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q15024

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component RRP42

Q9Y2L1

Interaction Score

P82979

(UniProtKB/Swiss-Prot/P) Details

SAP domain-containing ribonucleoprotein

Q9Y2L1

Interaction Score

O75083

(UniProtKB/Swiss-Prot/P) Details

WD repeat-containing protein 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Myelin sheath (GO:0043209)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Podosome (GO:0002102)	0.998	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cortical actin cytoskeleton (GO:0030864)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Actomyosin, actin part (GO:0042643)	0.998	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Cell projection (GO:0042995)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.3	Unknown: traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	1	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.998	Unknown: HDA	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell-cell junction (GO:0005911)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q8IWL3

(UniProtKB/Swiss-Prot/P) Details

Iron-sulfur cluster co-chaperone protein HscB, mitochondrial

Q9Y2L1

Interaction Score

Q8N140

(UniProtKB/Swiss-Prot/P) Details

EP300-interacting inhibitor of differentiation 3

Q9Y2L1

Interaction Score

O43602

(UniProtKB/Swiss-Prot/P) Details

Neuronal migration protein doublecortin

Q9Y2L1

Interaction Score

Q9NVA2

(UniProtKB/Swiss-Prot/P) Details

Septin-11

Q9Y2L1

Interaction Score

Q9Y371

(UniProtKB/Swiss-Prot/P) Details

Endophilin-B1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Midbody (GO:0030496)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Mitochondrion	Mitochondrial outer membrane (GO:0005741)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Autophagic vacuole membrane (GO:0000421)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Cytoplasmic vesicle (GO:0031410)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.96	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

Q5RKV6

(UniProtKB/Swiss-Prot/P) Details

Exosome complex component MTR3

Q9Y2L1

Interaction Score

Q9GZX7

(UniProtKB/Swiss-Prot/P) Details

Single-stranded DNA cytosine deaminase

Q9Y2L1

Interaction Score

A1X283

(UniProtKB/Swiss-Prot/P) Details

SH3 and PX domain-containing protein 2B

Q9Y2L1

Interaction Score

Q12792

(UniProtKB/Swiss-Prot/P) Details

Twinfilin-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: pTarget method	LOCATE	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Myofibril (GO:0030016)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	1	Experimental: experimental	Organelle	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	0.981	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Filopodium (GO:0030175)	0.981	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.981	Unknown: HDA	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.981	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

Q9UDV6

(UniProtKB/Swiss-Prot/P) Details

Zinc finger protein 212

Q9Y2L1

Interaction Score

P63092

(UniProtKB/Swiss-Prot/P) Details

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Q9Y2L1

Interaction Score

0.999

Q92733

(UniProtKB/Swiss-Prot/P) Details

Proline-rich protein PRCC

Q9Y2L1

Interaction Score

0.999

Q92988

(UniProtKB/Swiss-Prot/P) Details

Homeobox protein DLX-4

Q9Y2L1

Interaction Score

0.999

P02675

(UniProtKB/Swiss-Prot/P) Details

Fibrinogen beta chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.999	Experimental: experimental	eSLDB	PubMed
Membrane	Cell surface (GO:0009986)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cell cortex (GO:0005938)	0.98	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.8	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Platelet alpha granule (GO:0031091)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Platelet alpha granule lumen (GO:0031093)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytoskeleton (GO:0005856)	0.98	Experimental: experimental	Human Proteinpedia	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.996	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.996	Unknown: HDA	GO	PubMed
Extracellular	Fibrinogen complex (GO:0005577)	0.996	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Blood microparticle (GO:0072562)	0.996	Unknown: HDA	GO	PubMed
Extracellular	Extracellular matrix (GO:0031012)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.996	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.996	Unknown: traceable author statement	GO	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.996	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.98	Unknown: HDA	GO	PubMed
Membrane	Synapse (GO:0045202)	0.996	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

0.999

Q86U06

(UniProtKB/Swiss-Prot/P) Details

Probable RNA-binding protein 23

Q9Y2L1

Interaction Score

0.999

Q93034

(UniProtKB/Swiss-Prot/P) Details

Cullin-5

Q9Y2L1

Interaction Score

0.999

Q9BWW4

(UniProtKB/Swiss-Prot/P) Details

Single-stranded DNA-binding protein 3

Q9Y2L1

Interaction Score

0.999

Q9UGI8

(UniProtKB/Swiss-Prot/P) Details

Testin

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.988	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.988	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	0.86	Unknown: HDA	GO	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.86	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Cell junction (GO:0030054)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

0.998

P61923

(UniProtKB/Swiss-Prot/P) Details

Coatomer subunit zeta-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.994	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytosol (GO:0005829)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.994	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.994	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	COPI vesicle coat (GO:0030126)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Transport vesicle (GO:0030133)	0.994	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Vesicle (GO:0031982)	0.994	Experimental: experimental	eSLDB	PubMed

Interaction Source Database:

BioGRID, IntAct

Interaction Source Publication:

PubMed

, PubMed

Q9Y2L1

Interaction Score

0.997

Q13105

(UniProtKB/Swiss-Prot/P) Details

Zinc finger and BTB domain-containing protein 17

Q9Y2L1

Interaction Score

0.997

P84996

(UniProtKB/Swiss-Prot/P) Details

Protein ALEX

Q9Y2L1

Interaction Score

0.997

P49903

(UniProtKB/Swiss-Prot/P) Details

Selenide, water dikinase 1

Q9Y2L1

Interaction Score

0.996

Q9BW85

(UniProtKB/Swiss-Prot/P) Details

YJU2 splicing factor homolog

Q9Y2L1

Interaction Score

0.996

Q8IY67

(UniProtKB/Swiss-Prot/P) Details

Ribonucleoprotein PTB-binding 1

Q9Y2L1

Interaction Score

0.996

Q8WVK2

(UniProtKB/Swiss-Prot/P) Details

U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

Q9Y2L1

Interaction Score

0.995

Q5JWD1

(UniProtKB/TrEmbl/P) Details

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Q9Y2L1

Interaction Score

0.995

Q9UHD1

(UniProtKB/Swiss-Prot/P) Details

Cysteine and histidine-rich domain-containing protein 1

Q9Y2L1

Interaction Score

0.992

P04629

(UniProtKB/Swiss-Prot/P) Details

High affinity nerve growth factor receptor

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.897	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Cytosol	Intracellular membrane-bounded organelle (GO:0043231)	0.897	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.7	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.994	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.994	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Early endosome (GO:0005769)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Late endosome membrane (GO:0031902)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Early endosome membrane (GO:0031901)	0.994	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.994	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Lysosome (GO:0005764)	0.897	Predicted: pTarget method	LOCATE	PubMed
Membrane	Dendrite (GO:0030425)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axon (GO:0030424)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Receptor complex (GO:0043235)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

Q9Y2L1

Interaction Score

0.992

J3KQS6

(UniProtKB/TrEmbl/P) Details

BRISC and BRCA1-A complex member 1

Q9Y2L1

Interaction Score

0.988

B1AMU3

(UniProtKB/TrEmbl/P) Details

Exosome complex component CSL4

Q9Y2L1

Interaction Score

0.978

P05120

(UniProtKB/Swiss-Prot/P) Details

Plasminogen activator inhibitor 2

Q9Y2L1

Interaction Score

0.977

Q6P3W7

(UniProtKB/Swiss-Prot/P) Details

SCY1-like protein 2

Q9Y2L1

Interaction Score

0.969

G3V1Q4

(UniProtKB/TrEmbl/P) Details

Septin-7

Q9Y2L1

Interaction Score

0.968

Q99501

(UniProtKB/Swiss-Prot/P) Details

GAS2-like protein 1

Q9Y2L1

Interaction Score

0.96

G3V144

(UniProtKB/TrEmbl/P) Details

SH3 and PX domain-containing protein 2B

Q9Y2L1

Interaction Score

0.96

C9JA08

(UniProtKB/TrEmbl/P) Details

60S ribosomal export protein NMD3

Q9Y2L1

Interaction Score

0.96

S4R338

(UniProtKB/TrEmbl/P) Details

N-terminal Xaa-Pro-Lys N-methyltransferase 1

Q9Y2L1

Interaction Score

0.96

G3XAP0

(UniProtKB/TrEmbl/P) Details

Probable RNA-binding protein 23

Q9Y2L1

Interaction Score

0.96

Q5T081

(UniProtKB/TrEmbl/P) Details

CHC1 protein

Q9Y2L1

Interaction Score

0.957

A0A5E8

(UniProtKB/TrEmbl/P) Details

Growth arrest-specific 2 like 1, isoform CRA_a

Q9Y2L1

Interaction Score

0.954

P04798

(UniProtKB/Swiss-Prot/P) Details

Cytochrome P450 1A1

Q9Y2L1

Interaction Score

0.954

Q14455

(UniProtKB/TrEmbl/P) Details

Alpha subunit of GsGTP binding protein

Q9Y2L1

Interaction Score

0.945

Q9NZW5

(UniProtKB/Swiss-Prot/P) Details

MAGUK p55 subfamily member 6

Q9Y2L1

Interaction Score

0.94

E9PAU2

(UniProtKB/TrEmbl/P) Details

Ribonucleoprotein PTB-binding 1

Q9Y2L1

Interaction Score

0.94

A8K340

(UniProtKB/TrEmbl/P) Details

Neuronal migration protein doublecortin

Q9Y2L1

Interaction Score

0.94

H3BLV5

(UniProtKB/TrEmbl/P) Details

Neuronal migration protein doublecortin

Q9Y2L1

Interaction Score

0.91

Q53ES5

(UniProtKB/TrEmbl/P) Details

MUS81 endonuclease homolog

Q9Y2L1

Interaction Score

0.91

Q6IBA2

(UniProtKB/TrEmbl/P) Details

PC4 protein

Q9Y2L1

Interaction Score

0.91

Q8N6M8

(UniProtKB/Swiss-Prot/P) Details

IQ domain-containing protein F1

Q9Y2L1

Interaction Score

0.909

Q96FT4

(UniProtKB/TrEmbl/P) Details

Papillary renal cell carcinoma

Q9Y2L1

Interaction Score

0.847

Q5FWY2

(UniProtKB/TrEmbl/P) Details

GNAS complex locus

Q9Y2L1

Interaction Score

0.8

Q53EM1

(UniProtKB/TrEmbl/P) Details

Zinc finger and BTB domain containing 17 variant

Q9Y2L1

Interaction Score

0.799

A0A1B0GWD1

(UniProtKB/TrEmbl/P) Details

Neuronal migration protein doublecortin

Q9Y2L1

Interaction Score

0.799

A0A087WW40

(UniProtKB/TrEmbl/P) Details

Endophilin-B1

Q9Y2L1

Interaction Score

0.726

E9PFD7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q9Y2L1

Interaction Score

0.726

Q504U8

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q9Y2L1

Interaction Score

0.7

Q9NYS3

(UniProtKB/TrEmbl/P) Details

Apoptosis-related protein PNAS-3

Q9Y2L1

Interaction Score

0.7

Q9NW25

(UniProtKB/TrEmbl/P) Details

Single stranded DNA binding protein 3, isoform CRA_c

Q9Y2L1

Interaction Score

0.699

A4D0U5

(UniProtKB/TrEmbl/P) Details

Testis derived transcript (3 LIM domains), isoform CRA_d

Q9Y2L1

Interaction Score

0.64

B7Z2I3

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q9Y2L1

Interaction Score

0.64

E7BSV0

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q9Y2L1

Interaction Score

0.64

F2YGG7

(UniProtKB/TrEmbl/P) Details

Receptor protein-tyrosine kinase

Q9Y2L1

Interaction Score

0.64

X5DR71

(UniProtKB/TrEmbl/P) Details

Tyrosine-protein kinase receptor

Q9Y2L1

Interaction Score

0.49

Q546Y9

(UniProtKB/TrEmbl/P) Details

AID

Q9Y2L1

Interaction Score

0.49

Q6QJ80

(UniProtKB/TrEmbl/P) Details

Activation-induced cytidine deaminase

Q9Y2L1

Interaction Score

0.49

Q7Z599

(UniProtKB/TrEmbl/P) Details

Activation-induced cytidine deaminase

Q9Y2L1

Interaction Score

0.3

B4DV51

(UniProtKB/TrEmbl/P) Details

GTP-binding nuclear protein Ran

Q9Y2L1

Interaction Score

0.24

A0N0X8

(UniProtKB/TrEmbl/P) Details

Cytochrome P450

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Q9Y2L1

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

Q9Y2L1

Q14974

Importin subunit beta-1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q01780

Exosome component 10

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

P62826

GTP-binding nuclear protein Ran

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q9NWV8

BRISC and BRCA1-A complex member 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q06265

Exosome complex component RRP45

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q9NQT5

Exosome complex component RRP40

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

P53041

Serine/threonine-protein phosphatase 5

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q13868

Exosome complex component RRP4

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q9NPD3

Exosome complex component RRP41

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q16181

Septin-7

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q9NQT4

Exosome complex component RRP46

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1

Q12888

TP53-binding protein 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

Q9Y2L1