O43909

Exostosin-like 3 // UniProt Profile

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Species	H. sapiens
Number of Interactions	37 / 56
Average Interaction Score	0.758

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: pTarget method	LOCATE	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	1	Unknown: traceable author statement	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

First-Neighbour Network Visualization

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The first-neighbour network shows the interaction map after the filtration (if there was any).
Edge-widths are proportional to the respective Interaction Score.

Interactions

All Details

O43909

Interaction Score

Q53F39

(UniProtKB/Swiss-Prot/P) Details

Metallophosphoesterase 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Secretory-pathway	Endoplasmic reticulum exit site (GO:0070971)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Endoplasmic reticulum-Golgi intermediate compartment membrane (GO:0033116)	1	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Cis-Golgi network (GO:0005801)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.79	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

Q6AZY7

(UniProtKB/Swiss-Prot/P) Details

Scavenger receptor class A member 3

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.91	Predicted: PAML algorithm	PA-GOSUB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endoplasmic reticulum (GO:0005783)	0.999	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endoplasmic reticulum membrane (GO:0005789)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.999	Experimental: experimental	eSLDB	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.958	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Collagen (GO:0005581)	0.958	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Experimental: experimental	eSLDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.86	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

Q8TCT7

(UniProtKB/Swiss-Prot/P) Details

Signal peptide peptidase-like 2B

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Integral to cytosolic side of endoplasmic reticulum membrane (GO:0071458)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Integral to lumenal side of endoplasmic reticulum membrane (GO:0071556)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi membrane (GO:0000139)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Golgi-associated vesicle membrane (GO:0030660)	0.999	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endosome membrane (GO:0010008)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosomal membrane (GO:0005765)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Centrosome (GO:0005813)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.998	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.998

Q92633

(UniProtKB/Swiss-Prot/P) Details

Lysophosphatidic acid receptor 1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	Cell surface (GO:0009986)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Neuronal cell body (GO:0043025)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.96	Experimental: experimental	Organelle	PubMed
Nucleus	Nuclear speck (GO:0016607)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.96	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Endocytic vesicle (GO:0030139)	0.96	Experimental: inferred from direct assay	GO	PubMed
Membrane	Dendritic shaft (GO:0043198)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Dendritic spine (GO:0043197)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.998

Q6P5W5

(UniProtKB/Swiss-Prot/P) Details

Zinc transporter ZIP4

O43909

Interaction Score

0.996

P48960

(UniProtKB/Swiss-Prot/P) Details

CD97 antigen

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.86	Experimental: experimental	eSLDB	PubMed
Cytosol	Cytosol (GO:0005829)	0.86	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Secretory-pathway	Secretory granule membrane (GO:0030667)	0.86	Unknown: traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Experimental: experimental	eSLDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.988	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Membrane (GO:0016020)	0.998	Unknown: HDA	GO	PubMed
Membrane	Membrane (GO:0016020)	0.998	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.998	Experimental: experimental	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Unknown: traceable author statement	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.998	Experimental: experimental	Organelle	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.998	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.86	Unknown: HDA	GO	PubMed
Membrane	Focal adhesion (GO:0005925)	0.998	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.993

Q02297

(UniProtKB/Swiss-Prot/P) Details

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Secretory-pathway	Secretory pathway (GO:secretory_pathway)	0.8	Experimental: experimental	eSLDB	PubMed
Cytosol	Cell body (GO:0044297)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.51	Unknown: inferred from electronic annotation	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.996	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.996	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Dendrite (GO:0030425)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Axolemma (GO:0030673)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Unknown: non-traceable author statement	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.987	Predicted: PAML algorithm	PA-GOSUB	PubMed
Extracellular	Extracellular space (GO:0005615)	0.987	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Unknown: non-traceable author statement	GO	PubMed
Membrane	Membrane (GO:0016020)	0.976	Experimental: experimental	MatrixDB	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.976	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	0.976	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.993

P40259

(UniProtKB/Swiss-Prot/P) Details

B-cell antigen receptor complex-associated protein beta chain

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Membrane	B cell receptor complex (GO:0019815)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.971	Unknown: unspecified method	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.86	Unknown: unspecified method	The Human Protein Atlas	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.8	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Experimental: experimental	MatrixDB	PubMed
Extracellular	Extracellular region (GO:0005576)	0.94	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Integral to membrane (GO:0016021)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	0.999	Unknown: unspecified method	The Human Protein Atlas	PubMed
Membrane	External side of plasma membrane (GO:0009897)	0.999	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Integral to plasma membrane (GO:0005887)	0.999	Unknown: traceable author statement	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.971	Unknown: HDA	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.992

P62993

(UniProtKB/Swiss-Prot/P) Details

Growth factor receptor-bound protein 2

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Experimental: experimental	Human Proteinpedia	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.999	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.999	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Signalosome (GO:0008180)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Secretory-pathway	Golgi apparatus (GO:0005794)	0.86	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.86	Experimental: inferred from direct assay	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Unknown: traceable author statement	GO	PubMed
Membrane	Extrinsic to internal side of plasma membrane (GO:0031234)	0.971	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Grb2-EGFR complex (GO:0070436)	0.971	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.999	Unknown: HDA	GO	PubMed
Cytosol	Vesicle membrane (GO:0012506)	0.999	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.971	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.99

P06241

(UniProtKB/Swiss-Prot/P) Details

Tyrosine-protein kinase Fyn

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cell body (GO:0044297)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	Perinuclear endoplasmic reticulum (GO:0097038)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.7	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.94	Experimental: experimental	Human Proteinpedia	PubMed
Secretory-pathway	Endosome (GO:0005768)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Actin filament (GO:0005884)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Glial cell projection (GO:0097386)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Dendrite (GO:0030425)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Extrinsic to internal side of plasma membrane (GO:0031234)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.99

P12931

(UniProtKB/Swiss-Prot/P) Details

Proto-oncogene tyrosine-protein kinase Src

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Perinuclear region of cytoplasm (GO:0048471)	1	Unknown: inferred from electronic annotation	GO	PubMed
Mitochondrion	Mitochondrion (GO:0005739)	0.96	Experimental: inferred from direct assay	GO	PubMed
Mitochondrion	Mitochondrial inner membrane (GO:0005743)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Secretory-pathway	Late endosome (GO:0005770)	0.8	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Lysosome (GO:0005764)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Podosome (GO:0002102)	1	Unknown: inferred from electronic annotation	GO	PubMed
Cytosol	Actin filament (GO:0005884)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Ruffle membrane (GO:0032587)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuron projection (GO:0043005)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic density (GO:0014069)	1	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Extrinsic to internal side of plasma membrane (GO:0031234)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Caveola (GO:0005901)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	1	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.986

Q01524

(UniProtKB/Swiss-Prot/P) Details

Defensin-6

O43909

Interaction Score

0.984

Q6ZMH5

(UniProtKB/Swiss-Prot/P) Details

Zinc transporter ZIP5

O43909

Interaction Score

0.978

Q496J9

(UniProtKB/Swiss-Prot/P) Details

Synaptic vesicle glycoprotein 2C

O43909

Interaction Score

0.95

Q07001

(UniProtKB/Swiss-Prot/P) Details

Acetylcholine receptor subunit delta

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytosol (GO:0005829)	0.96	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	0.96	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Integral to membrane (GO:0016021)	1	Experimental: experimental	eSLDB	PubMed
Membrane	Acetylcholine-gated channel complex (GO:0005892)	1	Predicted: inferred from biological aspect of ancestor	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: inferred from direct assay	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: pTarget method	LOCATE	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: experimental	Organelle	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Membrane	Cell junction (GO:0030054)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Neuromuscular junction (GO:0031594)	1	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Postsynaptic membrane (GO:0045211)	1	Unknown: non-traceable author statement	GO	PubMed

Interaction Source Database:

BioGRID

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.95

P23416

(UniProtKB/Swiss-Prot/P) Details

Glycine receptor subunit alpha-2

O43909

Interaction Score

0.949

P28335

(UniProtKB/Swiss-Prot/P) Details

5-hydroxytryptamine receptor 2C

O43909

Interaction Score

0.949

P46098

(UniProtKB/Swiss-Prot/P) Details

5-hydroxytryptamine receptor 3A

O43909

Interaction Score

0.946

Q401N2

(UniProtKB/Swiss-Prot/P) Details

Zinc-activated ligand-gated ion channel

O43909

Interaction Score

0.94

P46108

(UniProtKB/Swiss-Prot/P) Details

Adapter molecule crk

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.978	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.978	Unknown: inferred by curator	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.978	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	0.978	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Unknown: traceable author statement	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.958	Experimental: experimental	Organelle	PubMed
Nucleus	Macromolecular complex (GO:0032991)	0.958	Predicted: inferred from physical interaction	GO	PubMed
Cytosol	Actin cytoskeleton (GO:0015629)	0.978	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane raft (GO:0045121)	0.971	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Unknown: inferred from electronic annotation	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Predicted: PAML algorithm	PA-GOSUB	PubMed
Membrane	Plasma membrane (GO:0005886)	0.971	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Extracellular vesicular exosome (GO:0070062)	0.978	Unknown: HDA	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.92

A0A0A0MR93

(UniProtKB/TrEmbl/P) Details

Metallophosphoesterase 1

O43909

Interaction Score

0.901

Q8N205

(UniProtKB/Swiss-Prot/P) Details

Nesprin-4

O43909

Interaction Score

0.89

P27986

(UniProtKB/Swiss-Prot/P) Details

Phosphatidylinositol 3-kinase regulatory subunit alpha

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytoplasm (GO:0005737)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Cytosol	Cytosol (GO:0005829)	1	Unknown: traceable author statement	GO	PubMed
Cytosol	Cytosol (GO:0005829)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Cytosol	Phosphatidylinositol 3-kinase complex (GO:0005942)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Cytosol	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex (GO:0005943)	1	Predicted: inferred from sequence or structural similarity	GO	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: SVM decision tree	eSLDB	PubMed
Nucleus	Nucleus (GO:0005634)	0.91	Predicted: inferred from sequence or structural similarity	GO	PubMed
Secretory-pathway	Cis-Golgi network (GO:0005801)	0.3	Unknown: inferred from electronic annotation	GO	PubMed
Extracellular	Extracellular region (GO:0005576)	0.8	Experimental: experimental	MatrixDB	PubMed
Membrane	Membrane (GO:0016020)	0.657	Unknown: HDA	GO	PubMed
Membrane	Plasma membrane (GO:0005886)	0.657	Unknown: traceable author statement	GO	PubMed
Membrane	Cell-cell junction (GO:0005911)	0.657	Unknown: inferred from electronic annotation	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43909

Interaction Score

0.881

Q9NX22

(UniProtKB/TrEmbl/P) Details

cDNA FLJ20482 fis, clone KAT07592

O43909

Interaction Score

0.859

P19174

(UniProtKB/Swiss-Prot/P) Details

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

O43909

Interaction Score

0.808

P98170

(UniProtKB/Swiss-Prot/P) Details

E3 ubiquitin-protein ligase XIAP

O43909

Interaction Score

0.798

Q9HAU0

(UniProtKB/Swiss-Prot/P) Details

Pleckstrin homology domain-containing family A member 5

O43909

Interaction Score

0.688

Q5VZX0

(UniProtKB/TrEmbl/P) Details

Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2, isoform CRA_a

O43909

Interaction Score

0.602

B3KT41

(UniProtKB/TrEmbl/P) Details

cDNA FLJ37598 fis, clone BRCOC2008642, highly similar to Synaptic vesicle glycoprotein 2C

O43909

Interaction Score

0.56

Q7RTW5

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-gamma

O43909

Interaction Score

0.56

Q6PK61

(UniProtKB/TrEmbl/P) Details

Neuregulin 1

O43909

Interaction Score

Q96G27

(UniProtKB/Swiss-Prot/P) Details

WW domain-binding protein 1

O43909

Interaction Score

P54253

(UniProtKB/Swiss-Prot/P) Details

Ataxin-1

Localizations:

Major Localization	Minor Localization	Localization Score	Experiment Type	Source Database	PubMed ID
Cytosol	Cytoplasm (GO:0005737)	0.998	Predicted: SVM decision tree	eSLDB	PubMed
Cytosol	Cytoplasm (GO:0005737)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: inferred from direct assay	GO	PubMed
Cytosol	Cytosol (GO:0005829)	0.998	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: pTarget method	LOCATE	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: experimental	Organelle	PubMed
Nucleus	Nucleus (GO:0005634)	1	Predicted: PAML algorithm	PA-GOSUB	PubMed
Nucleus	Nucleus (GO:0005634)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleolus (GO:0005730)	1	Experimental: annotated protein expression (APE)	The Human Protein Atlas	PubMed
Nucleus	Nuclear inclusion body (GO:0042405)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear matrix (GO:0016363)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nucleoplasm (GO:0005654)	1	Experimental: inferred from direct assay	GO	PubMed
Nucleus	Nuclear RNA export factor complex (GO:0042272)	1	Experimental: inferred from direct assay	GO	PubMed

Interaction Source Database:

IntAct

Interaction Source Publication:

PubMed

O43909

Interaction Score

O75170

(UniProtKB/Swiss-Prot/P) Details

Serine/threonine-protein phosphatase 6 regulatory subunit 2

O43909

Interaction Score

Q9H8X2

(UniProtKB/Swiss-Prot/P) Details

Inositol-pentakisphosphate 2-kinase

O43909

Interaction Score

Q7RTW3

(UniProtKB/TrEmbl/P) Details

Neuregulin 1 isoform HRG-beta2

O43909

Interaction Score

F6RJN6

(UniProtKB/TrEmbl/P) Details

Pro-neuregulin-1, membrane-bound isoform

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O43909

Species

Number of Interactions

Average Interaction Score

Localizations:

First-Neighbour Network Visualization

Interactions

O43909

Q53F39

Metallophosphoesterase 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

Q6AZY7

Scavenger receptor class A member 3

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

Q8TCT7

Signal peptide peptidase-like 2B

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

Q92633

Lysophosphatidic acid receptor 1

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

Q6P5W5

Zinc transporter ZIP4

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

P48960

CD97 antigen

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

Q02297

Pro-neuregulin-1, membrane-bound isoform

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

P40259

B-cell antigen receptor complex-associated protein beta chain

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

P62993

Growth factor receptor-bound protein 2

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

P06241

Tyrosine-protein kinase Fyn

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

P12931

Proto-oncogene tyrosine-protein kinase Src

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909

Q01524

Defensin-6

Localizations:

Interaction Source Database:

Interaction Source Publication:

O43909